A5031003740- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Radical Photochemical Reactions
- Asymmetric Synthesis and Catalysis
- Catalytic C–H Functionalization Methods
- Asymmetric Hydrogenation and Catalysis
- Free Radicals and Antioxidants
- Axial and Atropisomeric Chirality Synthesis
- Synthetic Organic Chemistry Methods
- Chemical Reaction Mechanisms
- Sulfur-Based Synthesis Techniques
Universidad Nacional Autónoma de México
2023-2024
Instituto Politécnico Nacional
2018-2023
A new practical method has been developed for the α-heteroarylation of aliphatic nitriles with heteroarenes and azobis(alkylcarbonitriles) using Cu(OAc)2 as an oxidizing agent. This allows easy construction nitrile-, aryl-, dialkyl-bearing quaternary carbon centers from readily available building blocks, without requiring prefunctionalization steps. reaction is based on adding cyanodialkyl radicals onto heteroarenes, including benzofurans, furans, pyrroles, indoles. The resulting...
Pseudo-C2-symmetric dodecaheterocyclic structures, which possess two acyl/aroyl groups disposed on either a cis- or trans-relative configuration, were prepared from the naturally occurring (-)-(1R)-myrtenal. Addition of Grignard reagents (RMgX) to diastereoisomeric mixture these compounds unexpectedly showed that nucleophilic additions prochiral carbonyl centers gave same stereochemical result in both cis/trans diastereoisomers, making unnecessary separation this mixture. Noticeably,...
Abstract In this work, we conducted a study of 7‐ exo ‐ trig cyclizations mechanism involving aryl, vinyl, and alkyl radicals on oxime ethers. Initially, the reaction brominated ether 9 with (TMS) 3 SiH AIBN gave rise to aryl that underwent cyclization ether, yielding dibenzoxepine 10 , ipso reduction products were obtained as well. Approximate rate constants at 80 °C for (1.0×10 8 s −1 ) (4.3×10 7 determined by competition experiments. DFT calculations showed good agreement experimental...