A5018780009- Oxidative Organic Chemistry Reactions
- Radical Photochemical Reactions
- Catalytic C–H Functionalization Methods
- Free Radicals and Antioxidants
- Synthesis of Organic Compounds
- Click Chemistry and Applications
- Carbohydrate Chemistry and Synthesis
- Antifungal resistance and susceptibility
Universidad Antonio Nariño
2022-2025
Pontificia Universidad Javeriana
2016-2023
Universidad Nacional de Colombia
2016
This study reports the synthesis, characterization, and antifungal evaluation of a series pyridoxal salicylaldehyde derivatives, using synthetic methodologies such as radical cyclizations click chemistry. Compounds 6a 6b, featuring fused dihydrobenzoxepine-pyridine scaffold, demonstrated effective fungicidal activity with MIC values 19 µg/mL against Cryptococcus neoformans 2807. Similarly, compound 6b exhibited notable 75 Candida auris PUJ-HUSI 537. Both compounds outperformed fluconazole...
Abstract In this work, we conducted a study of 7‐ exo ‐ trig cyclizations mechanism involving aryl, vinyl, and alkyl radicals on oxime ethers. Initially, the reaction brominated ether 9 with (TMS) 3 SiH AIBN gave rise to aryl that underwent cyclization ether, yielding dibenzoxepine 10 , ipso reduction products were obtained as well. Approximate rate constants at 80 °C for (1.0×10 8 s −1 ) (4.3×10 7 determined by competition experiments. DFT calculations showed good agreement experimental...
The mechanism and kinetic constants of the cascade cyclization involving vinyl, aryl N -alkoxyaminyl radicals for formation 1-azaspiro[4.4]nonanes.
Abstract The synthesis of the title chromanones leads to reasonably good yields and diastereoselectivity, when precursors contain a secondary alkyl bromide.