A5074777640- Pluripotent Stem Cells Research
- Epigenetics and DNA Methylation
- Developmental Biology and Gene Regulation
- Retinal Development and Disorders
- Hedgehog Signaling Pathway Studies
- CRISPR and Genetic Engineering
- Nuclear Receptors and Signaling
- Genomics and Chromatin Dynamics
- Mesenchymal stem cell research
- Adipose Tissue and Metabolism
- RNA regulation and disease
- Zebrafish Biomedical Research Applications
- 3D Printing in Biomedical Research
- Tissue Engineering and Regenerative Medicine
- Liver physiology and pathology
- Autophagy in Disease and Therapy
- Sirtuins and Resveratrol in Medicine
- Tea Polyphenols and Effects
- Neuroscience and Neural Engineering
- Cell Adhesion Molecules Research
Nara Institute of Science and Technology
2020-2023
University of Malaya
2018-2021
Neural induction is a process where naive cells are converted into committed with neural characteristics, and it occurs at the earliest step during embryogenesis. Although signaling molecules chromatin remodeling for have been identified, mutual relationships between these yet to be fully understood. By taking advantage of differentiation system mouse embryonic stem (ES) cells, we discovered that BMP signal regulates expression several polycomb repressor complex (PRC) component genes. We...
ABSTRACT Retinitis pigmentosa (RP) and macular dystrophy (MD) are characterized by gradual photoreceptor death in the retina often associated with genetic mutations, including those prominin-1 (Prom1) gene. Prom1-knockout (KO) mice recapitulate key features of these diseases light-dependent retinal degeneration constriction blood vessels. The mechanisms underlying such have remained unclear, however. We here analysed early events Prom1-KO mice. found that cell glial activation occur between...
Abstract During development, the hypothalamus emerges from ventral diencephalon and is regionalized into several distinct functional domains. Each domain characterized by a different combination of transcription factors, including Nkx2.1, Nkx2.2, Pax6, Rx, which are expressed in presumptive its surrounding regions, play critical roles defining each area. Here, we recapitulated molecular networks formed gradient Sonic Hedgehog (Shh) aforementioned factors. Using combinatorial experimental...
Understanding the molecular mechanisms leading to retinal development is of great interest for both basic scientific and clinical applications. Several signaling molecules transcription factors involved in have been isolated analyzed; however, determining direct impact loss a specific molecule problematic, due difficulties identifying corresponding cellular lineages different individuals. Here, we conducted genome-wide expression analysis with embryonic stem (ES) cells devoid Rx gene, which...
Neural induction is a process where naïve cells are converted into committed with neural characteristics, and occurs at the earliest step during embryogenesis. Although molecular mechanisms of induction, such as signal molecules chromatin remodelling, have been identified, correlations between these events yet to be fully understood.By taking advantage differentiation system mouse embryonic stem (ES) cells, we discovered that BMP regulates expression several Polycomb Repressor Complex (PRC)...
Abstract During development, the hypothalamus emerges from ventral diencephalon of neural tube and is regionalised into several distinct functional domains. Each domain characterised by different combinations transcription factors, expression which regulated signalling molecules downstream transcriptional networks. Transcription including Nkx2.1, Nkx2.2, Pax6 Rx, are expressed in presumptive its surrounding regions an early developmental stage play critical roles development these areas....