A5043168275- Parkinson's Disease Mechanisms and Treatments
- Zebrafish Biomedical Research Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Synthesis and Characterization of Heterocyclic Compounds
- Nuclear Receptors and Signaling
- Quinazolinone synthesis and applications
- Apelin-related biomedical research
- Intracerebral and Subarachnoid Hemorrhage Research
- Autophagy in Disease and Therapy
- Synthesis of Tetrazole Derivatives
- Neuroscience and Neuropharmacology Research
- Chromatography in Natural Products
- Inflammasome and immune disorders
- Acute Kidney Injury Research
- Alzheimer's disease research and treatments
- Adipokines, Inflammation, and Metabolic Diseases
- GABA and Rice Research
- Advanced Fluorescence Microscopy Techniques
- S100 Proteins and Annexins
- Neurofibromatosis and Schwannoma Cases
- Genomics, phytochemicals, and oxidative stress
- Clinical Nutrition and Gastroenterology
University of Malaya
2010-2023
Griffith University
2010-2012
University of Kuala Lumpur
2012
The study was carried out to determine the cytotoxic, antioxidant and gastro-protective effect of ethyl-4-[(3,5-di-tert-butyl-2-hydroxybenzylid ene)amino] benzoate (ETHAB) in rats.The cytotoxic ETHAB assessed using a MTT cleavage assay on WRL68 cell line, while its activity evaluated vitro. In anti-ulcer study, rats were divided into six groups. Group 1 group 2 received 10% Tween 20 (vehicle). 3 mg/kg Omeprazole. Groups 4, 5 6 at doses 5, 10, mg/kg, respectively. After an hour, vehicle. 2-6...
Kratom is a widely abused plant-based drug preparation with global interest in recent years, well beyond its native grounds Southeast Asia. Mitragynine, major psychoactive constituent known to exhibit opioid-like behavioral effects resultant neuroplasticity the brain reward system. Its chronic administration associated cognitive impairments animal studies. However, underlying molecular mechanism for such deficit remains elusive. In this study, involvement of cannabinoid type-1 (CB 1 )...
Background and purpose: Poly-L-glutamic acid (PG) has been used widely as a carrier to deliver anticancer chemotherapeutics. This study evaluates PG selective renal drug carrier. Experimental approach: 3 H-deoxycytidine-labeled PGs (17 or 41 kDa) H-deoxycytidine were administered intravenously normal rats streptozotocin-induced diabetic rats. The biodistribution of these compounds was determined over 24 h. Accumulation in kidneys also tracked using 5-(aminoacetamido) fluorescein...
Glial cell line-derived neurotrophic factor (GDNF) has been reported to enhance dopaminergic neuron survival and differentiation in vitro vivo, although those results are still being debated. (gdnf) is highly conserved zebrafish plays a role enteric nervous system function. However, little known about gdnf function the teleost brain. Here, we employed clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 impede maintenance of development. Genotyping crispants...
Background: Type 2 diabetes mellitus has recently been identified as a mediator of neurodegeneration. However, the molecular mechanisms have not clearly elucidated. We aimed to investigate insulin resistance associated with neurodegenerative events in zebrafish larvae. Methods: Larvae aged 72 h-post-fertilization (hpf) were induced by immersion 250 nM and then reinduced 100 at 96 hpf. This model was validated glucose levels assay, qPCR analysis selected genes (akt, pepck, zglut3 claudin-5a)...
A typical anatomical congregate and functionally distinct multicellular cerebrovascular dynamic confer diverse blood-brain barrier (BBB) microstructural permeabilities to conserve the health of brain parenchymal its microenvironment. This equanimity presupposes glymphatic system that governs flow clearance metabolic waste interstitial fluids (IF) through venous circulation. Following introduction concept, various studies have been carried out on cerebrospinal fluid (CSF) IF dynamics. These...
Glial cell line-derived neurotrophic factor (GDNF) was initially described as important for dopaminergic neuronal survival and is involved in many other essential functions the central nervous system. Characterization of GDNF phenotype mammals well described; however, studies non-mammalian vertebrate models are scarce. Here, we characterized anatomical distribution gdnf-expressing cells adult zebrafish brain by means combined situ hybridization (ISH) immunohistochemistry. Our results...
Epilepsy is a neurological disorder characterized by recurrent unprovoked seizures. Mounting evidence suggests the link between epileptogenesis and neuroinflammation. We hypothesize that eliminating neuroinflammation can alleviate seizure severity prolong onset. Channa striatus (CS) snakehead murrel commonly consumed locals in Malaysia, believed to promote wound healing mitigate inflammation. This study aims unravel anticonvulsive potential of CS extract on neuroinflammation-induced seizures...