A5014307231- Vitamin D Research Studies
- Vitamin C and Antioxidants Research
- Adipokines, Inflammation, and Metabolic Diseases
- Bone health and osteoporosis research
- Natural Antidiabetic Agents Studies
- Computational Drug Discovery Methods
- GDF15 and Related Biomarkers
- Olfactory and Sensory Function Studies
- melanin and skin pigmentation
- Regulation of Appetite and Obesity
- Biochemical Analysis and Sensing Techniques
- Metabolism, Diabetes, and Cancer
- Anesthesia and Neurotoxicity Research
- Zebrafish Biomedical Research Applications
Universiti Putra Malaysia
2018-2022
This study investigated the effects of vitamins D and E on an insulin-resistant model hypothesized that this treatment would reverse Alzheimer's disease (AD) improves insulin signalling. An was induced in SK-N-SH neuronal cells with a 250 nM re-challenged 100 at two different incubation time (16 h 24 h). The vitamin (10 20 ng/mL), form tocotrienol-rich fraction (TRF) (200 ng/mL) combination signalling markers (IR, PI3K, GLUT3, GLUT4, p-AKT), glucose uptake AD (GSK3β TAU) were determined...
Background and objective: Metformin is widely prescribed for the treatment of type 2 diabetes (T2D). Despite its extensive use, there are reports on patients who do not respond well even with good clinical compliance. The investigation metformin monotherapy effectiveness in T2D translated as responders or non-responders presented through biochemical analyses following a 3-month treatment. Methods: Sixty-five (65) patients, newly diagnosed from various community clinics Selangor, Kuala Lumpur...
Excessive production of melanin implicates hyperpigmentation disorders. Flavokawain A (FLA) and flavokawain B (FLB) have been reported with anti-melanogenic activity, but their melanogenic inhibition toxicity effects on the vertebrate model zebrafish are still unknown. In present study, cytotoxic as well FLA FLB cellular content tyrosinase activity were evaluated in α-MSH-induced B16/F10 cells. Master regulator microphthalmia-associated transcription factor (Mitf) other downstream...
Background: Type 2 diabetes mellitus has recently been identified as a mediator of neurodegeneration. However, the molecular mechanisms have not clearly elucidated. We aimed to investigate insulin resistance associated with neurodegenerative events in zebrafish larvae. Methods: Larvae aged 72 h-post-fertilization (hpf) were induced by immersion 250 nM and then reinduced 100 at 96 hpf. This model was validated glucose levels assay, qPCR analysis selected genes (akt, pepck, zglut3 claudin-5a)...
Evidences on vitamin D deficiency suggest there is increasing risk of diabetes. To date, some cohort, observation, cross-sectional studies populations and randomized controlled trials in supplements highlighting the potential are essentially modifying Type 2 Diabetes Mellitus (T2DM) pathophysiology. Relevant literature sought a various databases focus discovery Malaysia, particularly dietary, health status disease study. However, recent data scope focuses deficient mediated insulin...
An overview of vitamins D
Event Abstract Back to Neuro-recovery of vitamin E in high glutamate-induced oxidative stress neural cells derived from embryonic stem cell culture model Nurliyana Najwa Md Razip1, Afifah Abd Jalil1, Norshariza Nordin1, 2, Amirah Salwani Zaulkffli3, Nur'Izzati Mansor1, 2 and Huzwah Khaza'Ai1* 1 Department Biomedical Sciences, Faculty Medicine Health sciences, University Putra Malaysia, Malaysia Genetics Regenerative Research Centre, University, 3 Nutrition Dietetics, Universiti Background...