Nurshafika Mohd Sakeh

ORCID: 0000-0003-1624-3026
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About
Contact & Profiles
Research Areas
  • Plant-Microbe Interactions and Immunity
  • Plant Parasitism and Resistance
  • Oil Palm Production and Sustainability
  • melanin and skin pigmentation
  • Biochemical Analysis and Sensing Techniques
  • Olfactory and Sensory Function Studies
  • Plant pathogens and resistance mechanisms
  • Mycorrhizal Fungi and Plant Interactions
  • Biochemical and biochemical processes
  • Date Palm Research Studies
  • Zebrafish Biomedical Research Applications
  • Plant Pathogens and Fungal Diseases
  • Adipokines, Inflammation, and Metabolic Diseases
  • Biofuel production and bioconversion
  • Plant and animal studies
  • Regulation of Appetite and Obesity
  • Crystallization and Solubility Studies
  • X-ray Diffraction in Crystallography
  • Studies on Chitinases and Chitosanases
  • Insect and Arachnid Ecology and Behavior
  • Pharmacological Effects of Natural Compounds

Universiti Putra Malaysia
2014-2023

Basal stem rot (BSR) caused by hemibiotroph Ganoderma boninense is a devastating disease resulting in major loss to the oil palm industry. Since there no physical symptom at early stage of G. infection, characterisation molecular defense responses during interaction with fungus utmost importance. Oil (Elaeis guineensis) seedlings were artificially infected inoculums and root samples obtained following time-course 0, 3, 7, 11 days-post-inoculation (d.p.i) for RNA sequencing (RNA-seq)...

10.1186/s12870-018-1594-9 article EN cc-by BMC Plant Biology 2018-12-01

Excessive production of melanin implicates hyperpigmentation disorders. Flavokawain A (FLA) and flavokawain B (FLB) have been reported with anti-melanogenic activity, but their melanogenic inhibition toxicity effects on the vertebrate model zebrafish are still unknown. In present study, cytotoxic as well FLA FLB cellular content tyrosinase activity were evaluated in α-MSH-induced B16/F10 cells. Master regulator microphthalmia-associated transcription factor (Mitf) other downstream...

10.3390/molecules25153403 article EN cc-by Molecules 2020-07-28

The increasing activity of meliponiculture which plays a role as natural agricultural pollinator well the production stingless bee honey over time has encouraged high-impact research efforts around world. Stingless is known "superfood" product and received significant attention due to its various applications such treatment diseases both traditionally clinically. In this context, understanding interesting topics expanding network collaborations desirable advance towards integrated efforts,...

10.11113/mjfas.v20n2.3058 article EN Malaysian Journal of Fundamental and Applied Sciences 2024-04-24

Background: Type 2 diabetes mellitus has recently been identified as a mediator of neurodegeneration. However, the molecular mechanisms have not clearly elucidated. We aimed to investigate insulin resistance associated with neurodegenerative events in zebrafish larvae. Methods: Larvae aged 72 h-post-fertilization (hpf) were induced by immersion 250 nM and then reinduced 100 at 96 hpf. This model was validated glucose levels assay, qPCR analysis selected genes (akt, pepck, zglut3 claudin-5a)...

10.3390/ijms23158290 article EN International Journal of Molecular Sciences 2022-07-27

Abstract Background Hemibiotrophic pathogen such as the fungal Ganoderma boninense that is destructive to oil palm, manipulates host defense mechanism by strategically switching from biotrophic necrotrophic phase. Our previous study revealed two distinguishable expression profiles of palm genes formed basis in deducing phase at early interaction which switched a later stage infection. Results The present report continuing our published transcriptomic profiling seedlings against G. . We...

10.1186/s12870-020-02812-7 article EN cc-by BMC Plant Biology 2021-01-22

Abstract Background Hemibiotrophic pathogen such as the fungal Ganoderma boninense that is destructive to oil palm, manipulates host defense mechanism by strategically switching from biotrophic necrotrophic phase. Our previous study revealed two distinguishable expression profiles of palm genes formed basis in deducing phase at early interaction which switched later stage infection. Results The present report a continuing our published transcriptomic profiling seedlings against G. . We...

10.21203/rs.3.rs-33414/v1 preprint EN cc-by Research Square (Research Square) 2020-06-22
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