We suggest that the small inhibitors of AChE like coumarin and gallic acid's structure-based scaffolds may help in controlling Alzheimer's disease.

To dispose waste rubber tire is one of the major environmental issue all over world. Every year large number tires are buried or discarded world causing a serious threat to environment. Mostly used by some industries as fuel but we know this kind utilization has hazardous effect and can be uneconomical. Therefore, it needed use in such away so that might not affect environment at any cost. This paper presents scrap an alternative steel fiber reinforced concrete. Four types concrete mix were...

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In this research work, Zinc(II) and Aluminum(III)-IIP's were synthesized by optimizing the amount of methacrylic acid as monomer, divinylbenzene cross-linker. The IIP's functionalized with 8-hydroxy quinolone complexes two metal ions under thermal conditions copolymerization monomer Non-IIP's characterized using FT-IR, TGA, SEM analysis. A quite remarkable difference in size was observed polymers (Zn(II) 1.0 µm Al(III) 0.1 µm). stronger affinity IIP comparison Non-IIP at pH 3.1 4.5 for...

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Abstract Thymidine monophosphate kinase from Mycobacterium tuberculosis (TMPK Mtub ) is an established drug target against tuberculosis. The enzyme TMPK responsible for the survival of bacterium MTB and required to synthesize essential building block bacterial DNA which thymidine triphosphate (TTP). There are several potent inhibitors available but majority substrate analogues. Recently, three dimensional structures inhibitor complexes were resolved using X‐ray crystallography. These crystal...

Abstract Fluoroquinolones are extensively used in clinical applications as a crucial class of antibacterial medicine and have shown high potential for the treatment several other diseases. This study is based on synthesis, structure elucidation biological evaluation various fluoroquinolone ( enoxacin ) analogues with electrophilic substitution aromatic amine moiety central nucleus by benzyl halides. The synthesized derivatives were characterized basis different chemical physical measurements...

Abstract Metal complexes have pivotal applications in catalysis, photochemistry, and biological systems. Due to their unique chemical properties, metal occupy a coveted place the field of drug design. The present study includes synthesis symmetrical oxamides ( O1 – O11 ) copper C1 C11 that potential inhibit α‐glucosidase lipoxygenase enzymes. To elucidate structures these compounds, spectroscopic investigations including mass spectrometry, 1 H‐NMR spectroscopy, UV‐Visible spectroscopy IR...

Deep learning (DL) has changed how we handle huge amount of data like big data. The ability DL to large scale (Volume), speed (Velocity), diversity (variance), and structured (accuracy) is the focus this paper, helps perform important aspects solving complex problems. Pattern recognition, real-time speech processing, hybrid processing (e.g., text, images, video) are all feasible for models such as convolutional neural networks CNNs) (RNNs). Research shows that can improve decision-making...

Reverse transcriptase is the most therapeutic target for discovery of novel, potent, and non-toxic new anti-retroviral drugs. In present work, various docking software such as Sybyl Surflex-Dock, OpenEye FRED, Hermes GOLD were evaluated their efficiency to reproduce known cognate inhibitors' conformations. Three metrics used compared assess performance applied scoring functions, i.e. enrichment factor, receiver operating characteristic (ROC) curves, Bedroc analysis. Twelve different...

Abstract Diabetes mellitus (DM) is a well‐known progressive endocrine disorder and has become serious worldwide medical concern stimulating the search for new therapeutic agents. In current study, nitrogen oxygen based twenty oxamide derivatives were synthesized their potential to inhibit α ‐glucosidase enzyme was studied. Oxamides using oxalyl chloride corresponding aniline in 1 : 2 ratio basic medium. Structures of these compounds determined by mass spectrometry, various spectroscopic...

ABSTRACT. Ti(III) and (IV) hydrazide complexes were synthesized, characterized, screened for their tyrosinase lipoxygenase inhibitory cytotoxic activities. The geometry of is tentatively assigned as octahedral. Magnetic moments found around 1.7 B.M. electronic spectral transition in the range 495-518 nm. Evaluation Ti(IV) activities revealed varying inhibition potential. Hydrazide ligands inactive against tyrosinase, while significant activity was observed (LOX). Good to moderate by both...

The α-chymotrypsin is widely present in the digestive system of prokaryotes and eukaryotes that helps digestion by hydrolysis peptide bond. It serine protease enzyme (E.C. 3.4.21.1) involves many biological processes as well pancreatic disorders. In previous study, marine red alga namely Jolyna laminariodes was used for isolation succinylanthranilic acid ester (2). Further, analogues were synthesised from anthranilic using succinic anhydride, maleic anhydride glutaric into corresponding...

In this study, new levofloxacin loaded mesoporous silica nanoparticles were prepared by sol–gel technique using tetraethyl orthosilicate (TEOS) as precursor and cetyltrimethylammonium bromide (CTAB) pore generating agent. The synthesis conditions tailored varying the molar ratio of water, NaOH amount CTAB used. synthesized carriers characterized Scanning Electron Microscope (SEM) which showed that spherical particles with an average size between 80-87 nm prepared. UV Infra Red Spectroscopy...

A combination of biologically active ligand and metal in one molecule may increase the activity reduce toxicity.In this study, synthesis characterization platinum(IV) complexes with bioactive hydrazide ligands are discussed.Elemental analysis, conductivity measurements, spectroscopic studies were used to elucidate structure complexes.Our study suggests that coordinate Pt(IV) a bidentate fashion. The have octahedral geometry ratio 1:2. Hydrazide coordinated central by oxygen carbonyl group...

Normodyne is the brand name of Labetalol. It has medicinal importance and well known antihypertensive drug given to patient in severe hypertension condition. two-fold alpha beta adrenergic antagonism dissimilar physiological effects acute condition high blood pressure. Various techniques were used elaborate qualitative behavior this drug. In present work, Cyclic Voltammetry (CV) determine characteristics The Glassy Carbon Electrode (GCE) as a working Calomel reference electrode with...

Introduction: Keloids are the result of an overgrowth dense fibrous tissue that usually develops after healing a skin injury. The exact pathogenesis is unknown and their occurrence spontaneous. uncontrolled extends beyond borders original wound does not regress. No single therapeutic modality has been proven to be most effective for treatment therefore this study plan use intralesional steroids injection in keloid measure efficacy see if it better cost method also determine its utility...

Abstract Cross-project defect prediction (CPDP) is a significant way of identification in the project. In cross-project prediction, we extract knowledge from source project and apply that learned to predict labels for target However, model performance can be affected by features are insignificant irrelevant. Hybrid feature selection (HFS) play role achieving high accuracy selecting only relevant features. Our aim explore effect through hybrid approach upon (CP) datasets which multi-class...