A5047765112- Genomics, phytochemicals, and oxidative stress
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Antimicrobial Peptides and Activities
- Protein Hydrolysis and Bioactive Peptides
- Histone Deacetylase Inhibitors Research
- Click Chemistry and Applications
- Biomedical and Engineering Education
- Regulation of Appetite and Obesity
- Essential Oils and Antimicrobial Activity
- Bioactive Compounds and Antitumor Agents
- Peptidase Inhibition and Analysis
- Cancer, Hypoxia, and Metabolism
- Synthesis and biological activity
- Bee Products Chemical Analysis
- Adipokines, Inflammation, and Metabolic Diseases
- Biochemical and Structural Characterization
- Insect and Pesticide Research
- Nigella sativa pharmacological applications
- Eicosanoids and Hypertension Pharmacology
- Dietary Effects on Health
- Pharmacological Effects of Medicinal Plants
- PI3K/AKT/mTOR signaling in cancer
- Aquatic life and conservation
- Piperaceae Chemical and Biological Studies
Universiti Putra Malaysia
2016-2025
Southampton General Hospital
2010-2012
University of Southampton
2009-2012
Cancer Research UK
2010-2012
Faculty (United Kingdom)
2011
Cambridge University Press
2010
New York University Press
2010
N1-Hydroxy-N8-ferrocenyloctanediamide, JAHA (7), an organometallic analogue of SAHA containing a ferrocenyl group as phenyl bioisostere, displays nanomolar inhibition class I HDACs, excellent selectivity over IIa and anticancer action in intact cells (IC50 = 2.4 μM, MCF7 cell line). Molecular docking studies 7 HDAC8 (a,b) suggested that the moiety can overlap with aryl cap should display similar HDAC inhibition, which was borne out vitro assay values against (μM, SD parentheses): SAHA, 1.41...
Ethnopharmacological Relevance. Colon cancer has been a major problem worldwide. Kelulut honey (KH) is produced by the stingless bees from Trigona species and strong antioxidant activities that could be one of potential chemopreventive agents natural resources. Aim This Study. study investigated properties toxicity KH in Sprague Dawley rats induced with azoxymethane (AOM). Material Method. Twenty-four male aged 5 weeks were divided into 4 groups: (G1) untreated group not AOM, (G2) (G3)...
This study investigated the effects of vitamins D and E on an insulin-resistant model hypothesized that this treatment would reverse Alzheimer's disease (AD) improves insulin signalling. An was induced in SK-N-SH neuronal cells with a 250 nM re-challenged 100 at two different incubation time (16 h 24 h). The vitamin (10 20 ng/mL), form tocotrienol-rich fraction (TRF) (200 ng/mL) combination signalling markers (IR, PI3K, GLUT3, GLUT4, p-AKT), glucose uptake AD (GSK3β TAU) were determined...
Phenethyl isothiocyanate (PEITC) is a naturally occurring electrophile which depletes intracellular glutathione (GSH) levels and triggers accumulation of reactive oxygen species (ROS). PEITC considerable interest as potential chemopreventive/chemotherapeutic agent, in this work, we have investigated the effects on human breast cancer cell lines. Whereas readily induced apoptosis MDA-MB-231 cells (associated with rapid activation caspases 9 3, decreased expression BAX), MCF7 were relatively...
The ferrocene analogue <bold>4b</bold> had an IC<sub>50</sub> = 4 nM (HDAC1), 180 (HDAC8) and was effective in a <italic>Xenopus</italic> model of tubulin deacetylation. Analogue <bold>4a</bold> displayed mainly μM values against HDACs apart from HDAC6 (IC<sub>50</sub> 69 nM).
Thymoquinone (TQ), a bioactive compound found in Nigella sativa , cannot be orally consumed due to its lipophilicity. In order overcome this low bioavailability, TQ is loaded into colloidal drug carrier known as nanostructured lipid (NLC). This study aims determine the antiproliferative effects of and TQ‐NLC on liver cancer cells integrated with hepatitis B genome, Hep3B. The Hep3B was treated or for 24, 48, 72 hours via MTT assay. results confirm that inhibited growth at IC50 <16.7 μ M...
Previous study has shown the antimicrobial activities of mucus protein extracted from Anabas testudineus. In this study, we are interested in characterizing anticancer activity A. testudineus peptides (AMPs). The was extracted, fractioned, and subjected to antibacterial testing confirm fish's AMPs production. cytotoxic each fraction also identified. Fraction 2 (F2), which shows toxicity against MCF7 MDA-MB-231 were sent for peptide sequencing identify bioactive peptide. two then...
Dietary intake of isothiocyanates (ITC) has been associated with reduced cancer risk. The dietary phenethyl ITC (PEITC) previously shown to decrease the phosphorylation translation regulator 4E binding protein 1 (4E-BP1). Decreased 4E-BP1 linked inhibition cell survival and decreased activity transcription factor hypoxia-inducible (HIF), a key positive angiogenesis, may therefore contribute potential anti-cancer effects PEITC. In present study, we have investigated in vitro vivo watercress,...
Phenethyl isothiocyanate (1) is a natural dietary phytochemical with cytostatic, cytotoxic, and antitumor activity. The effects of 1 were investigated on the activity mTOR, kinase that enhances translation many RNAs encoding proteins critical for cancer cell growth, including angiogenesis regulator HIF1α. Compound effectively blocked HIF1α RNA in MCF7 breast cells, this was associated reduced phosphorylation 4E-BP1 p70 S6K, well-characterized downstream substrates mTOR-containing mTORC1...
Wound healing is a regulated biological event that involves several processes including infiltrating leukocyte subtypes and resident cells. Impaired wound one of the major problems in diabetic patients due to abnormal physiological changes tissues cells processes. Thymoquinone, bioactive compound found Nigella sativa has been demonstrated possess antidiabetic, anti-inflammatory, antioxidant effects. Today, rapidly progressing nanotechnology sets new alternative carrier enhance favour speed...
Rapid outbreak of coronavirus disease 2019 has caused the implementation movement control order (MCO) which aimed to reduce spread in Covid-19 infections. While some may find it easy adjust new norm, others found difficult switch from their normal routines and habits as according MCO SOP. This resulted a more frequent insomnia depression that subsequently impacted mental health. Insomnia levels are examined this study they relate Pandemic among Malaysian undergraduate health sciences...
Background: Type 2 diabetes mellitus (T2DM) is a chronic metabolic syndrome that rapidly increasing across the world, especially in Malaysia. Leptin plays vital role regulation of metabolism through its effect on peripheral tissues. G2548A polymorphism LEP gene promoter has been associated with insulin resistance, leptin, and type different population, but not inclusively reported within Malaysian population.
Anabas testudineus is a sturdy freshwater fish that can live in polluted environment due to the epidermal mucus (EM) protects from pathogens or germs. This study explored functional properties of EM as potential antimicrobial and anticancer agent. Inactive Pseudomonas aeruginosa was introduced into tanks stimulate production EM. stimulus significantly increased by more than 100% after 10 days stimulation, indicating influenced environmental biotic stress. In vitro antibacterial activity...
Various studies have demonstrated that directed evolution is a powerful tool in enhancing protein properties. In this study, was used to enhance the efficacy of synthesised Anabas testudineus AtMP1 antimicrobial peptides (AMPs) inhibiting proliferation cancer cells. The modification and prediction peptide properties using bioinformatic tools were carried out four databases, including ADP3, CAMP-R3, AMPfun, ANTICP. One modified (AMP), ATMP6 (THPPTTTTTTTTTTTTTAAPARTT), chosen based on its...