A5065499318- Antimicrobial Peptides and Activities
- Protein Hydrolysis and Bioactive Peptides
- Bioactive natural compounds
- Lung Cancer Treatments and Mutations
- Chronic Lymphocytic Leukemia Research
- Biochemical and Structural Characterization
- Natural product bioactivities and synthesis
- Aquaculture disease management and microbiota
- Sirtuins and Resveratrol in Medicine
- Colorectal Cancer Treatments and Studies
INTI International University
2024
Amgen (United States)
2022
Sotorasib, a specific, irreversible KRAS G12C inhibitor, is approved in multiple countries for adults with p.G12C-mutated locally advanced or metastatic NSCLC who have received prior systemic therapy. Approval was based on the global phase 1/2 CodeBreaK 100 trial, which also investigated sotorasib other solid tumours, including colorectal cancer (CRC). Here we describe putative mechanisms of acquired resistance to patients CRC. Patients CRC from CodeBreaK100 trial monotherapy at 960 mg once...
Cratoxylum formosum ssp. (Cff), C. pruniflorum (Cfp), and sumatranum (Cs) were investigated for phytochemical analysis. Toxicity testing, programmed cell death, cycle arrest tested on CHL-1, HCT-116, HepG2 cancer lines, human normal PBMCs. The results are revealed in the following order. percentages varied each species, quantity concentration of α-amyrin resveratrol 0.038 mg/g 0.955 mg/mL, 0.064 0.640 mg/mL. most studied extracts showed IC50 values PBMCs lines except hexane Cff ethanol Cfp...
Various studies have demonstrated that directed evolution is a powerful tool in enhancing protein properties. In this study, was used to enhance the efficacy of synthesised Anabas testudineus AtMP1 antimicrobial peptides (AMPs) inhibiting proliferation cancer cells. The modification and prediction peptide properties using bioinformatic tools were carried out four databases, including ADP3, CAMP-R3, AMPfun, ANTICP. One modified (AMP), ATMP6 (THPPTTTTTTTTTTTTTAAPARTT), chosen based on its...