A5072813545- Microbial Metabolic Engineering and Bioproduction
- Computational Drug Discovery Methods
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Ferroptosis and cancer prognosis
- Cancer-related gene regulation
- Cancer Immunotherapy and Biomarkers
- Childhood Cancer Survivors' Quality of Life
- Immune cells in cancer
- Ubiquitin and proteasome pathways
- NF-κB Signaling Pathways
- Cancer-related molecular mechanisms research
- Cancer survivorship and care
- Pediatric Pain Management Techniques
- interferon and immune responses
- Family Support in Illness
- Inflammatory mediators and NSAID effects
- Metalloenzymes and iron-sulfur proteins
- Infant Development and Preterm Care
- Cancer Genomics and Diagnostics
- Gene Regulatory Network Analysis
- Angiogenesis and VEGF in Cancer
- MicroRNA in disease regulation
Sun Yat-sen University
2013-2025
Sun Yat-sen University Cancer Center
2017-2025
State Key Laboratory of Oncology in South China
2022-2023
Sun Yat-sen Memorial Hospital
2020
Metabolic enzymes have an indispensable role in metabolic reprogramming, and their aberrant expression or activity has been associated with chemosensitivity. Hence, targeting remains attractive approach for treating tumors. However, the influence regulation of cysteine desulfurase (NFS1), a rate-limiting enzyme iron-sulfur (Fe-S) cluster biogenesis, colorectal cancer (CRC) remain elusive. Here, using vivo gene-based clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9...
Objective Methionine metabolism is involved in a myriad of cellular functions, including methylation reactions and redox maintenance. Nevertheless, it remains unclear whether methionine metabolism, RNA antitumour immunity are molecularly intertwined. Design The effect methionine-restricted diet (MRD) feeding was assessed murine models. mechanisms YTH domain-containing family protein 1 (YTHDF1) tumour immune escape were determined vitro vivo. synergistic effects MRD or YTHDF1 depletion with...
Abstract Colorectal cancer (CRC) patients with liver metastases usually obtain less benefit from immunotherapy, and the underlying mechanisms remain understudied. Here, we identify that fibrinogen-like protein 1 (FGL1), secreted cells hepatocytes, facilitates progression of CRC in an intraportal injection model by reducing infiltration T cells. Mechanistically, tumor-associated macrophages (TAMs) activate NF-ĸB secreting TNFα/IL-1β microenvironment transcriptionally upregulate OTU...
Because of medical advances, metastatic breast cancer (MBC) is now viewed as a chronic disease, rather than an imminent death sentence. Helping women live with this disease requires more approach to symptoms. Thus, mentor-based and supportive-expressive program 'Be Resilient Breast Cancer' (BRBC) was designed help Chinese MBC enhance their resilience levels, biopsychosocial functions, potentially extend life span.A total 226 were randomly assigned, in 1 : ratio, intervention group (IG) that...
Cancer stem cells play a central role in the pathogenesis of nasopharyngeal carcinoma and contribute to both disease initiation relapse.In this study, cyclooxygenase-2 (COX-2) was found regulate cancer stem-like side population enhance cells' characteristics such as higher colony formation efficiency overexpression stemness-associated genes.The regulatory effect COX-2 on may be mediated by ABCG2.COX-2 gain-of-function experiment increased proportion their stemness properties.The present...
Abstract Background Cancer cells undergo global reprogramming of cellular metabolism to satisfy demands energy and biomass during proliferation metastasis. Computational modeling genome-scale metabolic models is an effective approach for designing new therapeutics targeting dysregulated cancer by identifying enzymes crucial satisfying goals cells, but nearly all previous studies neglect the existence other than synthesis trade-offs between these contradicting demands. It thus necessary...
Previously, we identified the genetic variant −241 (−/G) (rs11453459) in PP2A-Aα gene (PPP2R1A) promoter and demonstrated that this influences DNA-binding affinity of nuclear factor-kappa B (NF-κB). In study, further confirmed transcriptional activity PPP2R1A may be regulated by NF-κB through functional (−/G). Moreover, also methylation status CpG islands promoter. Few studies have examined role or epigenetic regulation hepatocellular carcinoma (HCC). To investigate whether is associated...
Abstract Early detection is warranted to improve prognosis of gastric cancer (GC) but remains challenging. Liquid biopsy combined with machine learning will provide new insights into diagnostic strategies GC. Lipid metabolism reprogramming plays a crucial role in the initiation and development tumors. Here, we integrated lipidomics data three cohorts ( n = 944) develop lipid metabolic landscape We further constructed serum signature (SLMS) by learning, which showed great performance...
Parents of children diagnosed with cancer often experience high levels illness uncertainty. This study evaluated the psychometric properties Chinese Version Parent Perception Uncertainty Scale for Childhood Cancer (PPUS-CC) in Mainland China.Exploratory factor analysis (EFA) and confirmatory (CFA) were performed using population 420 parents. The participants also given social support questionnaire assessed Self-Rating Anxiety Scale, Zarit Burden Interview, Depression to test association...
Abstract Computational modeling of the genome-wide metabolic network is essential for designing new therapeutics targeting cancer-associated disorder, which a hallmark human malignancies. However, previous studies generally assumed that fluxes cancer cells are subjected to maximization biomass production, despite wide existence trade-offs among multiple objectives. To address this issue, we developed multi-objective model metabolism with algorithms depicting approximate Pareto surfaces and...
Background: Emerging evidence indicates that bile acids (BAs) play pivotal roles in hepatocellular carcinoma (HCC). Farnesoid X receptor (FXR), the of BAs, is considered to be a regulator immune response and inflammation various diseases. However, relevance microenvironment FXR HCC unknown.Methods: Flow cytometry analyses were performed measure apoptosis rates cells checkpoint changes cells. Kaplan-Meier analysis with log-rank test for assessing overall survival time recurrence was...