A5021617235- Chromosomal and Genetic Variations
- Plant Molecular Biology Research
- RNA modifications and cancer
- Plant nutrient uptake and metabolism
- Plant Virus Research Studies
- Genomics and Phylogenetic Studies
- Plant responses to water stress
- Plant Disease Resistance and Genetics
- Advanced biosensing and bioanalysis techniques
- CRISPR and Genetic Engineering
- Genomic variations and chromosomal abnormalities
- Plant Stress Responses and Tolerance
- Cocoa and Sweet Potato Agronomy
- Coconut Research and Applications
- Plant tissue culture and regeneration
- Viral Infections and Vectors
- Invertebrate Immune Response Mechanisms
- Food composition and properties
- Legume Nitrogen Fixing Symbiosis
- Peanut Plant Research Studies
- Agricultural pest management studies
- Genetics and Neurodevelopmental Disorders
- Gene expression and cancer classification
- Peptidase Inhibition and Analysis
- Phytoplasmas and Hemiptera pathogens
Institut de Recherche sur le Cancer et le Vieillissement de Nice
2016-2024
Inserm
2020-2023
Centre National de la Recherche Scientifique
2017-2023
Observatoire de la Côte d’Azur
2023
Université Côte d'Azur
2020-2022
Université de Perpignan
2017-2021
Diversité, adaptation et développement des plantes
2017-2021
Institut de Recherche pour le Développement
2017-2021
Université de Montpellier
2017-2021
Laboratoire Génome et Développement des Plantes
2018-2019
Like many other crops, the cultivated peanut (Arachis hypogaea L.) is of hybrid origin and has a polyploid genome that contains essentially complete sets chromosomes from two ancestral species. Here we report sequence show after its origin, evolved through mobile-element activity, deletions by flow genetic information between corresponding (that is, homeologous recombination). Uniformity patterns recombination at ends favors single for wild counterpart A. monticola. However, much genome,...
Long interspersed element 1 (L1) retrotransposons are implicated in human disease and evolution. Their global activity is repressed by DNA methylation, but deciphering the regulation of individual copies has been challenging. Here, we combine short- long-read sequencing to unveil L1 methylation heterogeneity across cell types, families, loci elucidate key principles involved. We find that youngest primate families specifically hypomethylated pluripotent stem cells placenta not most tumors....
Retrotransposons are mobile genetic elements abundant in plant and animal genomes. While efficiently silenced by the epigenetic machinery, they can be reactivated upon stress or during development. Their level of transcription not reflecting their transposition ability, it is thus difficult to evaluate contribution active mobilome. Here we applied a simple methodology based on high throughput sequencing extrachromosomal circular DNA (eccDNA) forms retrotransposons characterize repertoire...
Retrotransposons play a central role in plant evolution and could be powerful endogenous source of genetic epigenetic variability for crop breeding. To ensure genome integrity several silencing mechanisms have evolved to repress retrotransposon mobility. Even though retrotransposons fully depend on transcriptional activity the host RNA polymerase II (Pol II) their mobility, it was so far unclear whether Pol is directly involved repressing activity. Here we show that plants defective lose DNA...
Abstract The Human Silencing Hub (HUSH) complex constituted of TASOR, MPP8 and Periphilin recruits the histone methyl-transferase SETDB1 to spread H3K9me3 repressive marks across genes transgenes in an integration site-dependent manner. deposition these leads heterochromatin formation inhibits gene expression, but underlying mechanism is not fully understood. Here, we show that TASOR silencing or HIV-2 Vpx which induces degradation, increases accumulation transcripts derived from HIV-1 LTR...
Trees are long-lived organisms that continuously adapt to their environments, a process in which epigenetic mechanisms likely play key role. Via downregulation of the chromatin remodeler DECREASED IN DNA METHYLATION 1 (DDM1) poplar (Populus tremula × Populus alba) RNAi lines, we examined how methylation coordinates genomic and physiological responses moderate water deficit. We compared growth drought response two RNAi-ddm1 lines wild-type (WT) trees under well-watered deficit/rewatering...
The challenge of sustaining food security in the context global changes is at heart plant research. Environmental stresses, particular, are known to impact genome stability and epigenetic mechanisms. Epigenetic pathways well characterized plants, particularly dicotyledon model Arabidopsis thaliana, but an increasing number epigenomic studies also performed on rice (Oryza sativa). Rice represents a major crop worldwide importance good for monocotyledons owing its relatively small size fully...
SUMMARY Long interspersed element-1 (L1) retrotransposons play important roles in human disease and evolution. Their global activity is repressed by DNA methylation, but studying the regulation of individual copies has been difficult. Here, we combine short- long-read sequencing to resolve methylation profiles these repeated sequences a panel normal cancer cells genome-wide at single-locus resolution. We unveil key principles underpinning L1 heterogeneity among cell-types, families...
Journal Article Cancer Immunotherapy: How to Exploit Transposable Elements? Get access Sophie Lanciano, Lanciano University Cote d'Azur, Inserm, CNRS, Institute for Research on and Aging of Nice (IRCAN), Faculty Medicine, Nice, France Address correspondence to: S.L. at 28 av Valombrose, 06107, France. E-mail Sophie.Lanciano@univ-cotedazur.fr. G.C. Gael.Cristofari@univ-cotedazur.fr. https://orcid.org/0000-0002-2958-8405 Search other works by this author on: Oxford Academic Google Scholar Gael...
Abstract As fixed and long living organisms subjected to repeated environmental stresses, trees have developed mechanisms such as phenotypic plasticity that help them cope with fluctuating conditions. Here, we tested the role DNA methylation a hub of integration, linking physiological response water deficit in shoot apical meristem model tree poplar ( Populus ). Using reverse genetic approach, compared hypomethylated RNAi- ddm1 lines wild-type for drought tolerance. An integrative analysis...