A5079472934- Phytochemicals and Antioxidant Activities
- Food composition and properties
- Botanical Research and Applications
- Genomics, phytochemicals, and oxidative stress
- Epigenetics and DNA Methylation
- Multiple Myeloma Research and Treatments
- Polysaccharides Composition and Applications
- Ferroptosis and cancer prognosis
- Microbial Metabolites in Food Biotechnology
- Cell death mechanisms and regulation
- Chemical synthesis and alkaloids
- Consumer Attitudes and Food Labeling
- Acute Myeloid Leukemia Research
- Edible Oils Quality and Analysis
- Agricultural and Food Sciences
- Chronic Myeloid Leukemia Treatments
- Natural product bioactivities and synthesis
- Phytochemistry Medicinal Plant Applications
- Bioactive natural compounds
- PI3K/AKT/mTOR signaling in cancer
- Cholesterol and Lipid Metabolism
- Advanced biosensing and bioanalysis techniques
- Hippo pathway signaling and YAP/TAZ
- Freezing and Crystallization Processes
- Cancer Mechanisms and Therapy
Azienda Ospedaliera Sant'Andrea
2023
San Raffaele University of Rome
2022
Istituti di Ricovero e Cura a Carattere Scientifico
2014-2019
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2019
University of Urbino
2014-2019
Vita-Salute San Raffaele University
2019
Mutations in genes encoding chromatin-remodeling proteins are often identified a variety of cancers. For example, the histone demethylase JARID1C is frequently inactivated patients with clear cell renal carcinoma (ccRCC); however, it largely unknown how dysfunction promotes cancer. Here, we determined that binds broadly to chromatin domains characterized by trimethylation lysine 9 (H3K9me3), which mark enriched heterochromatin. Moreover, found localizes on heterochromatin, required for...
DNA replication is a tightly regulated process that initiates from multiple origins and leads to the faithful transmission of genetic material. For proper replication, chromatin surrounding needs be remodeled. However, remarkably little known on which epigenetic changes are required allow firing origins. Here, we show histone demethylase KDM5C/JARID1C for at early JARID1C dictates assembly pre-initiation complex, driving binding proteins CDC45 PCNA, through demethylation mark H3K4me3. Fork...
Moringin (MOR), a glycosyl-isothiocyanate obtained by myrosinase-catalyzed hydrolysis of the precursor 4-(α-l-rhamnosyloxy)-benzyl glucosinolate (glucomoringin), found predominantly in seeds Moringa oleifera, shows anticancer effects against several cancer cell lines. Avenanthramide (AVN) 2f is phytochemical purified from oats with antioxidant and properties. The aim this study was to investigate antiproliferative proapoptotic MOR AVN used alone combination on Hep3B cells, which are highly...
Betacyanins (BC) were purified from beetroot (Beta vulgaris var. rubra L.) and tested, alone or in combination with vitexin-2-O-xyloside (XVX) Beta cicla L., for their ability to reduce the proliferation rate T24 bladder cancer cells. Combination of BC XVX exhibited a synergistic effect concerning inhibition cells at 24 48 h but not after 72 incubation. The induction apoptosis was evidenced by means fluorescence activated cell sorting (FACS) analysis, as well through increase caspase 3 8...
In this study, we applied Environmental Scanning Electron Microscopy-Energy Dispersive Spectroscopy (ESEM-EDS) and Atomic Force Microscopy (AFM) analysis to three different cereal caryopses: barley, oat einkorn wheat. The morphological structures, chemical elemental composition surface characteristics of the cereals were described. Regarding morphology, barley showed thickest pericarp, providing a strong barrier digestion absorption nutrients. aleurone layer each type contained protein body...
In this investigation, 14 extra virgin olive oils (EVOOs), produced with Leccino and Raggiola cultivars, by a new two-way (2W) decanter were compared EVOOs means of conventional three-way (3W) decanter. The 2W had higher phenol concentrations, as shown high-performance liquid chromatography/diode array detection (HPLC-DAD) analysis yielded extraction the 3,4-DHPEA-EDA (oleacein), 3,4-DHPEA-EA (oleuropein aglycone) p-HPEA-EDA (oleocanthal). concentrations lignans, (+)-pinoresinol...
Avenanthramides (AVNs) are natural polyphenols obtained from oat sprouts and can also be chemically synthetized. The aim of the present study was to assess anticancer, anti-inflammatory antioxidant effects individual synthetized AVNs (s-2c, s-2p, s-2f) a AVN mixture (n-MIX) on CaCo-2 Hep3B cancer cells. In CaCo-2, s-2c found most cytotoxic followed by n-MIX. cells, marked effect but no significant difference observed between synthesized both synthetic activated caspases 8 3, n-MIX were able...
Summary In this study, we compare the histological localisation of phenols and β‐glucan in six cereal cross sections. The concentrations total whole grain flour ( WGF ) were also investigated to provide their nutrient content grams. Cross sections durum, soft, einkorn emmer wheat, oats barley stained with Azan Trichrome ATH periodic acid–Schiff PAS characterise morphology cytohistology living cells aleurone, subaleurone germ, as well a‐nucleated starchy endosperm. Phenol outer layers was...
Summary This study evaluated the effects of malting and in vitro digestion on bioaccessibility six avenanthramides (AVNs), soluble phenols (SPs) antioxidant capacity (ORAC) cookies (3B, 4B, 5B) prepared with oat flour malted for three (M3), four (M4), five (M5) days, respectively. Control (CTRL) were made non‐malted (M0). Five‐days increased AVN content native kernels up to 10‐folds, whereas SPs ORAC tripled their values. After digestion, AVNs showed following order: 5B > 4B 3B, a...
Summary Antioxidant capacities of energy drinks ( ED ) and gels EG were evaluated by means Oxygen Radical Absorbance Capacity ORAC ), Trolox Equivalent TEAC Ferric‐ion Reducing Power FRAP 2,2‐Diphenyl‐1‐picrylhydrazyl DPPH assays. Values obtained the four methods linearly correlated a ranking scale their antioxidant contributes was drawn. The values per serving ranged between 100–7610 26–404 μmol Equivalents TE respectively, with total phenols TP ). compared number coffee, tea sport SDR...
The basic ingredients used to make the Italian soffritto were studied in order define polyphenol, antioxidant capacity and lycopene content of homemade or commercial tomato sauces, as well their contribute whole wheat refined pasta. The addition aromatic herbs sauces increased polyphenols capacity, with basil providing biggest boost, whereas rea dy-made showed lowest values. Cooked pasta sauce offers an enormous amount antioxidants, which could protect against oxidative stress.