A5039853948- Chronic Lymphocytic Leukemia Research
- Monoclonal and Polyclonal Antibodies Research
- Immunodeficiency and Autoimmune Disorders
- Lymphoma Diagnosis and Treatment
- Galectins and Cancer Biology
- Epigenetics and DNA Methylation
- Multiple Myeloma Research and Treatments
- Glycosylation and Glycoproteins Research
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Phagocytosis and Immune Regulation
- PI3K/AKT/mTOR signaling in cancer
- Immune Cell Function and Interaction
- Chronic Myeloid Leukemia Treatments
- Cancer therapeutics and mechanisms
- Kruppel-like factors research
- Autoimmune Bullous Skin Diseases
- Graphene and Nanomaterials Applications
- Occupational and environmental lung diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cell Adhesion Molecules Research
- RNA Research and Splicing
- Advanced Breast Cancer Therapies
- Genetics and Neurodevelopmental Disorders
- CAR-T cell therapy research
IRCCS Ospedale San Raffaele
2022-2025
Vita-Salute San Raffaele University
2006-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2015-2024
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2019-2024
San Raffaele University of Rome
2009-2023
University of Bologna
2003
Mature B-cells can recognize microbial antigens via B-cell-receptor (BCR) in a specific way and Toll-like receptors (TLR) costimulatory manner. A wealth of information is gathering on the possible role antigenic stimulation natural history Chronic Lymphocytic Leukaemia (CLL). However little known regarding repertoire function TLR CLL cells. The family includes 10 different transmembrane proteins devoted to pathogen-associated molecular patterns alarm immunocompetent cells trigger an immune...
Mutations in genes encoding chromatin-remodeling proteins are often identified a variety of cancers. For example, the histone demethylase JARID1C is frequently inactivated patients with clear cell renal carcinoma (ccRCC); however, it largely unknown how dysfunction promotes cancer. Here, we determined that binds broadly to chromatin domains characterized by trimethylation lysine 9 (H3K9me3), which mark enriched heterochromatin. Moreover, found localizes on heterochromatin, required for...
DNA replication is a tightly regulated process that initiates from multiple origins and leads to the faithful transmission of genetic material. For proper replication, chromatin surrounding needs be remodeled. However, remarkably little known on which epigenetic changes are required allow firing origins. Here, we show histone demethylase KDM5C/JARID1C for at early JARID1C dictates assembly pre-initiation complex, driving binding proteins CDC45 PCNA, through demethylation mark H3K4me3. Fork...
Abstract Splenic marginal zone lymphoma (SMZL) is a distinct clinical and pathological entity among lymphomas. Genetic microenvironmental factors leading to aberrant activation of the NF‐κB pathway have been implicated in SMZL pathogenesis. CYLD negative regulator other signaling pathways acting as deubiquitinase regulatory molecules has reported tumor suppressor different types cancer, including B‐cell malignancies. To assess whether natural history SMZL, we profiled primary cells from...
Multiple myeloma is a malignant still incurable plasma cell disorder. Pharmacological treatment based on proteasome inhibition has improved patient outcome; however, bortezomib-resistance remains major clinical problem. Inhibition of functionality affects cellular iron homeostasis and potent inducer reactive oxygen species death, unless safely stored in ferritin. We explored the potential role bortezomib-resistance. analyzed proteins, oxidative status viability 7 multiple lines cells from 5...
Abstract Malignant Mesothelioma is a highly aggressive cancer, which difficult to diagnose and treat. Here we describe the molecular, cellular morphological characterization of syngeneic system consisting murine AB1, AB12 AB22 mesothelioma cells injected in immunocompetent BALB/c mice, allows study interplay tumor with immune system. Murine cells, like human ones, respond exogenous High Mobility Group Box 1 protein, Damage-Associated Molecular Pattern that acts as chemoattractant for...
Therapeutic strategies designed to tinker with cancer cell DNA damage response have led the widespread use of PARP inhibitors for BRCA1/2-mutated cancers. In haematological multiple myeloma, we sought identify analogous synthetic lethality mechanisms that could be leveraged upon established treatments. The combination ATR inhibition using compound VX-970 a drug eliciting interstrand cross-links, melphalan, was tested in vitro, ex vivo, and most notably vivo models. Cell proliferation,...
Background: Identification of novel strategies to improve Chronic Lymphocytic Leukemia (CLL) outcome is primary importance as the disease remains incurable. Malignant B cells show high levels reactive oxygen species (ROS), which favors adaptation but also enhances sensitivity pro-oxidant therapeutics. Redox homeostasis affected by iron balance since excess works and cancer rearrange trafficking proteins promote uptake. This might be exploited an Achilles' heel exposing cause ROS generation,...
The oncogenic role of common fragile sites (CFS), focal and pervasive gaps in the cancer genome arising from replicative stress, remains controversial. Exploiting TCGA dataset, we found that most CFS genes residing within associated deletions are down-regulated, including proteins involved tumour immune recognition. In a subset CFS, however, surprisingly overexpressed. Within frequent this group, FRA4F, which is deleted up to 18% cases harbours CCSER1 gene, identified region includes an...
Chronic lymphocytic leukemia (CLL), the most frequent in western world, cannot be cured with current treatment strategies. The central clinical problem of CLL is to define which patients should treated, when and how. Dissecting natural history disease may identify mechanisms prove prognostic value or lead molecules potential interest as targets. rationale this approach demonstrated by observation that analysis mutational status Variable genes Immunoglobulin (Ig) heavy chains (IgVH) has...
Topic: 20. Lymphoma Biology & Translational Research Background: Splenic Marginal zone lymphoma (SMZL) is a distinct clinical and pathologic entity among indolent B-cell lymphomas arising from marginal B-cells. Genetic microenvironmental factors, leading to the aberrant activation of NF-κB pathway, have been implicated in its pathogenesis. CYLD negative regulator other signaling pathways, acting as deubiquitinase regulatory molecules has reported tumor suppressor different types neoplasias...