A5000120321- Hepatitis Viruses Studies and Epidemiology
- Liver Disease and Transplantation
- Viral gastroenteritis research and epidemiology
- Liver Diseases and Immunity
- Substance Abuse Treatment and Outcomes
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Prenatal Substance Exposure Effects
- Child Abuse and Trauma
- Veterinary medicine and infectious diseases
- Opioid Use Disorder Treatment
- Homelessness and Social Issues
- Viral Infections and Immunology Research
- Sepsis Diagnosis and Treatment
- Infection Control in Healthcare
- Attention Deficit Hyperactivity Disorder
- Clinical Reasoning and Diagnostic Skills
- Medicinal Plants and Bioactive Compounds
- Viral-associated cancers and disorders
- Drug-Induced Hepatotoxicity and Protection
- Simulation-Based Education in Healthcare
- Eosinophilic Disorders and Syndromes
- Hemoglobinopathies and Related Disorders
- Forensic Toxicology and Drug Analysis
Royal Cornwall Hospital
2010-2018
Royal Cornwall Hospital Trust
2013-2018
University of Exeter
2012-2017
Public Health England
2015
Cornwall Council
2015
Peninsula College of Medicine and Dentistry
2012-2014
Radboud University Medical Center
2014
Jeroen Bosch Ziekenhuis
2014
Erasmus University Rotterdam
2014
National Institute for Public Health and the Environment
2014
The aim of the study was to determine whether Guillain-Barré syndrome (GBS) is associated with preceding hepatitis E virus infection.The frequency (HEV) infections determined by anti-HEV serology in a cohort 201 patients GBS and healthy controls similar distribution age, sex, year sampling. Blood samples from were obtained acute phase before treatment. In subgroup GBS, blood, stool, CSF tested for HEV RNA.An increased ratio immunoglobulin (Ig) M antibodies found 10 (5.0%) compared 1 control...
To determine whether there is an association between acute preceding hepatitis E virus (HEV) infection and neuralgic amyotrophy (NA), if so, patients with HEV-related NA differ from without associated HEV infection.HEV testing was conducted in a retrospective cohort of 28 Cornish (2011-2013) prospective 38 consecutive Dutch (2004-2007). Acute-phase serum samples were analyzed for the presence anti-HEV immunoglobulin (Ig) M IgG RNA (quantitative real-time PCR).Five cases (10.6%) identified...
Summary Background Autochthonous (locally acquired) hepatitis E is increasingly recognised in developed countries, and thought to be a porcine zoonosis. A range of extra‐hepatic manifestations infection have been described, but never systematically studied. Aim To report the virus. Methods Retrospective review data 106 cases autochthonous (acute n = 105, chronic 1). Results Eight (7.5%) presented with neurological syndromes, which included brachial neuritis, Guillain‐Barré syndrome,...
ABSTRACT Aims To compare the effects of a short or long taper schedule after buprenorphine stabilization on participant outcomes as measured by opioid‐free urine tests at end each period. Design This multi‐site study sponsored Clinical Trials Network (CTN, branch US National Institute Drug Abuse) was conducted from 2003 to 2005 two conditions (7 days and 28 days). Data were collected weekly clinic visits periods, 1‐month 3‐month post‐taper follow‐up visits. Setting Eleven out‐patient...
Summary Background In developed countries, hepatitis E is a porcine zoonosis caused by virus ( HEV ) genotype 3. developing mainly 1, and causes increased mortality in patients with pre‐existing chronic liver disease CLD ). Aim To determine the role of decompensated . Methods Prospective testing 343 at three UK centres Toulouse France, follow‐up for 6 months or death. IgG seroprevalence was compared 911 controls. Results 11/343 (3.2%) had acute infection, died. There were no differences (27%...
Abnormal liver blood tests are common in Epstein-Barr virus (EBV) infection, but symptomatic hepatitis is rare. The demographics, clinical features and outcome of EBV incompletely understood, particularly the elderly people.To identify presenting natural history hepatitis.Retrospective review 1995 consecutive patients attending jaundice hotline clinic over a 13-year period. Data collected included demographic information, features, laboratory parameters, radiology imaging outcome.Seventeen...
The interplay between host antiviral immunity and immunopathology during hepatitis E virus (HEV) infection determines important clinical outcomes. We characterized the specificity, functionality, durability of T‐cell responses against full‐length HEV assessed a novel “Quantiferon” assay for rapid diagnosis infection. Eighty‐nine volunteers were recruited from Oxford, Truro (UK), Toulouse (France), including 44 immune‐competent patients with acute infection, 18 HEV‐exposed immunosuppressed...
Abstract Women report extensive histories of childhood abuse, often leading to addiction. Studies assessing the same effects for men are lacking. This study describes adverse events (CAEs) among methamphetamine (MA)-dependent and women assesses relationship CAEs onset severity dependence. Baseline three-year interview data were collected 236 351 women. Dependent variables included MA reported greater occurrence all types than (28% vs. 13%, p < .01). Familial substance abuse was most...
Abstract Locally acquired HEV infection is increasingly recognized in developed countries. Anti‐HEV IgG seroprevalence has been shown to be high haemodialysis patients a number of previous studies, employing assays uncertain sensitivity. The aim this study was investigate anti‐HEV recipients and renal transplants compared control group using validated, highly sensitive assay. Eighty‐eight with functioning 76 receiving chronic were tested for RNA IgM. Six hundred seventy controls IgG....
Background Forty percent of patients with autoimmune hepatitis (AIH) present acute jaundice/hepatitis. Such patients, when treated promptly, are thought to have a good prognosis. Objectives The objective this study was describe the natural history AIH in presenting jaundice/hepatitis and determine whether diagnosis could been made earlier, before presentation. Methods This is retrospective review 2249 consecutive who presented jaundice Jaundice Hotline clinic, Truro, Cornwall, UK, over 15...
Seronegative hepatitis is a recognized cause of liver failure requiring transplantation. The aetiology unknown, but might relate to an unidentified virus or immune dysregulation. There are few data on seronegative presenting nontransplant centres.To describe the clinical/laboratory features and natural history compare these with viral/autoimmune hepatitis.Cases seronegative, viral autoimmune were identified from 2080 consecutive patients attending rapid-access jaundice clinic over 14-year...
Autochthonous hepatitis E virus (HEV) infection is a porcine zoonosis and increasingly recognized in developed countries. In most cases the route of uncertain. A previous study showed that HEV was associated geographically with pig farms coastal areas.The aim present research to geographical, environmental social factors autochthonous infection.Cases genotype 3 controls were identified from 2047 consecutive patients attending rapid-access hepatology clinic. For each case/control following...
: Medical conditions in methamphetamine (MA) users have not been well characterized. Using both self-report and physical examination data, the aims of this study were to (1) describe frequency medical a sample MA 3 years posttreatment; (2) evaluate association between use frequency; (3) examine relationship route administration with outcomes.: MA-dependent adults (N = 301) who participated Methamphetamine Treatment Project interviewed examined after treatment. Medical, demographic, substance...
In California, Proposition 36 (Prop. 36) has led to positive outcomes for a significant proportion of participants-increases in drug treatment completion, reduced use and recidivism, increased employment. However, there are notable differences among Prop. subgroups, with some the poorest observed opioid users. This may be because very few users were placed narcotic programs (NTPs). who NTPs using methadone had greatest reductions from intake discharge, as compared received outpatient...
SUMMARY Thirty-three of 72 heroin addicts attending a recognized clinic for drug addition had history jaundice, but in only five was the serum positive hepatitis-associated antigen (HAA) when examined by immunodiffusion, immunoelectro-osmophoresis and complement fixation. Two these were repeatedly over an 8–12 month follow-up period liver biopsy showed chronic persistent hepatitis. A third later developed acute study injection habits suggested that present low incidence HAA decrease number...