A5064078212- Amyloidosis: Diagnosis, Treatment, Outcomes
- Renal Transplantation Outcomes and Treatments
- Renal Diseases and Glomerulopathies
- Cancer Immunotherapy and Biomarkers
- Organ Transplantation Techniques and Outcomes
- Polyomavirus and related diseases
- Muscle and Compartmental Disorders
- Pregnancy and Medication Impact
- Chronic Kidney Disease and Diabetes
- Hepatitis C virus research
- Dialysis and Renal Disease Management
- Multiple Myeloma Research and Treatments
- Diabetes and associated disorders
- Bone and Joint Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Acute Kidney Injury Research
- Peptidase Inhibition and Analysis
- Liver Disease and Transplantation
- Lung Cancer Treatments and Mutations
- Organ Donation and Transplantation
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Orthopaedic implants and arthroplasty
- Viral-associated cancers and disorders
- Pharmacological Effects and Toxicity Studies
- Electrolyte and hormonal disorders
Cleveland Clinic
2024-2025
University of Kansas Medical Center
2021-2022
Mayo Clinic
2020-2021
University of Kansas
2021
University Medical Center
2021
Abstract Background: IrAEs are common complications of ICI therapy and can have diverse manifestations, affecting nearly any organ system often requiring multi-disciplinary care. An institutional irAE tumor board is an effective tool to facilitate multidisciplinary collaboration expedite care these pts. We report the clinical application our board. Methods: performed a retrospective review pts discussed at Cleveland Clinic Taussig Cancer Center since establishment in 2017. The meets...
Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy, but to the authors' knowledge, limited data exist regarding safety and efficacy of these agents in transplant recipients. Herein, authors reported their experience with 17 patients who were treated ICIs for metastatic malignancies after undergoing solid organ transplantation.Data abstracted recipients received treatment malignancy between January 1, 2016, September 30, 2019. The identified 7 kidney, 8 liver, 2 heart...
Although capillary leak syndrome has a high mortality rate, its trigger, diagnosis, and treatment remain challenge to clinicians because of the poor understanding mechanism lack guidelines. With extended use immune checkpoint inhibitors in modern oncology, inhibitor–associated immune-related adverse events have also expanded. We present case pembrolizumab-induced lymphatic dysfunction which patient had an excellent clinical response tailored strategy.
Immune checkpoint inhibitors (ICPis) are humanized monoclonal antibodies that now commonly used to harness the immune system's ability fight hematological and solid organ malignancies.1,2 However, when overactivation of system occurs, multiple organs can be affected, particularly with phenomenon termed immune-related adverse events (irAEs).3 Acute kidney injury (AKI), specifically, acute interstitial nephritis (AIN), is most common renal irAEs reported.4,5 As a result, some current practice...
Myeloma-related kidney disease has several manifestations; the 2 most common histologic diagnoses are myeloma cast nephropathy and acute tubular necrosis. We describe a case of different pathologies occurring concomitantly in patient found to have immunoglobulin A κ multiple myeloma. White woman her 70s presented with an 8-month history back pain was nephrotic-range proteinuria injury. Serum calcium level 12.6 mg/dL. Kidney biopsy showed light chain only proliferative glomerulonephritis...
Acute kidney injury (AKI) is known to be associated with increased mortality, and racial differences in hospital mortality exist patients AKI. However, it remains seen whether post-hospitalization among AKI patients.We analyzed data of adult admitted the University Virginia Medical Center between January 1, 2001, December 31, 2015, compare in-hospital hospitalized black white Multivariable logistic regression analysis was used analyze association race 90-day that were discharged....
Early acute kidney rejection remains an important clinical issue.The current study included 552 recipients who had 1-2 surveillance or indication biopsy within the 1 y posttransplant. We evaluated impact of type allograft inflammation on outcome. They were divided into 5 groups: no (NI: 95), subclinical (SCI: 244), T cell-mediated (TCMR) (SC-TCMR: 110), TCMR (C-TCMR: 83), and antibody-mediated (AMR: 20). Estimated glomerular filtration rate (eGFR) over time using linear mixed model,...
Calciphylaxis also known as calcific uraemic arteriolopathy is a rare condition mostly seen in patients with end-stage kidney disease. We report case of simultaneous-kidney-pancreas transplant patient functioning grafts developing biopsy-proven calciphylaxis the setting chronic inflammation. Despite several modalities management, developed progression her disease leading to multiple amputations. This illustrates inflammation driven by persistent infection probable contributing factor...
Lipoprotein deposition disorders limited to the kidney and causing proteinuria are rare. We present a case of nephrotic range presenting within 4 months after deceased donor renal transplantation in patient with end-stage disease presumed secondary hypertension. Two transplant biopsies were performed sixteen weeks transplantation, one year first biopsy, both showing lipoprotein deposits glomeruli, progressive focal segmental glomerulosclerosis, effacement visceral foot processes. The had...
Multiple myeloma is the most frequent malignant monoclonal gammopathy and second common hematological malignancy after non-Hodgkin lymphoma. There continues to be evolving therapies in treatment which has significantly changed progression-free overall survival of patients. Increasingly, evidence shows that multiple no longer portends poor lethal prognosis. With advances improved as seen several studies, perhaps more attention should focus on kidney transplantation these individuals given...