A5003378130- Cardiac Imaging and Diagnostics
- Renal Transplantation Outcomes and Treatments
- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Cardiac electrophysiology and arrhythmias
- Cardiac Health and Mental Health
- Cardiac Arrhythmias and Treatments
- Renal Diseases and Glomerulopathies
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Vascular Procedures and Complications
- Neurotransmitter Receptor Influence on Behavior
- Cardiac pacing and defibrillation studies
- Neuroscience and Neuropharmacology Research
- Congenital Heart Disease Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Coronary Artery Anomalies
- Organ Transplantation Techniques and Outcomes
- Polyomavirus and related diseases
- Parkinson's Disease Mechanisms and Treatments
- Kawasaki Disease and Coronary Complications
- Heart Failure Treatment and Management
- Venous Thromboembolism Diagnosis and Management
- Heart Rate Variability and Autonomic Control
King George's Medical University
2015-2025
University of Pittsburgh Medical Center
2019-2024
Chitkara University
2014-2024
Mayo Clinic in Arizona
2024
UPMC Health System
2023
St. Luke's University Health Network
2022-2023
Rothman Orthopaedics
2023
St. Stephen’s Hospital
2023
Concordia University
2022
MNR Dental College and Hospital
2022
ABSTRACT Background: Numerous previous studies have explored transradial coronary angioplasty, yet none exclusively focused on the female population. Aim: The aim of this study was to assess feasibility and safety 5 Fr Glidesheath Slender (GSS) (Terumo, Tokyo, Japan) in comparison 6 Standard Sheath (SS) Indian patients undergoing angiography or percutaneous intervention (PCI). Materials Methods: This a prospective, randomized controlled, single-center study. A total 100 diagnosed with artery...
Text-to-picture alludes to the conversion of a textual description into semantically similar image.The automatic synthesis top-quality pictures from text portrayals is both exciting and useful at same time.Current AI systems have shown significant advances in field,but work still far complete. Recent field Deep Learning resulted introduction generative models that are capable generating realistic images when trained appropriately.In this paper,authors will review advancements architectures...
ATAC-seq is widely used to measure chromatin accessibility and identify open regions (OCRs). OCRs usually indicate active regulatory elements in the genome are directly associated with gene network. The identification of differential (DARs) between different biological conditions critical determining activity elements. Differential analysis shares many similarities expression RNA-seq data. However, distribution signal intensity from that data, higher sensitivity required for DARs...
Primary percutaneous coronary intervention (PCI) is the preferred treatment for ST-segment elevation myocardial infarction (STEMI). However, in patients with high thrombus burden, immediate stenting during PCI can lead to poor outcomes due risk of migration and subsequent microvascular occlusion, resulting no-reflow phenomena. Deferred offers a potential advantage by allowing reduction load, which may help minimize incidence slow-flow complications. This study explores effectiveness deferred...
This is an open-label randomized control trial with a parallel assignment single masking comparing patients undergoing coronary angiography via dorsal radial and classical access.
Methamphetamine (METH) is a highly abused psychostimulant that neurotoxic to dopaminergic (DAergic) nerve terminals in the striatum and increases risk of developing Parkinson's disease (PD). In vivo, METH-mediated DA release, followed by DA-mediated oxidative stress mitochondrial dysfunction pre- postsynaptic neurons, mediates METH neurotoxicity. METH-triggered damages parkin, neuroprotective protein involved PD etiology via its involvement maintenance mitochondria. It not known whether...
<b><i>Background:</i></b> Limited evidence from small-scale studies, mainly involving end-stage renal disease (ESRD) patients, suggests that kidney transplantation may improve cognitive function. We examined changes in function after a transplant and its association with survival advanced chronic (CKD)/ESRD patients. <b><i>Methods:</i></b> In prospective study design, performance of 90 patients (50.6 ± 13.1 years, 66.7% men, 27.8% blacks, 76%...
We analyzed whether there is an interaction between the Kidney Donor Index (KDPI) and cold ischemia time (CIT) in recipients of deceased donor kidney transplant (KT). Adults who underwent KTs United States 2014 2020 were included divided into three KDPI groups (< 20%, 21-85%, > 85%) four CIT strata 12, 12-17.9, 18-23.9, ≥ 24 hours). Multivariate analyses used to test for following outcomes: primary graft non-function (PGNF), delayed function (DGF), estimated glomerular filtration rate at 6...
High calcineurin inhibitor (CNI) intrapatient variability (IPV) has been associated with poor kidney allograft outcomes. However, the relationship between early histological changes, their progression, and CNI-IPV is less well studied. Hence, we evaluated effect of defined by degree fluctuation CNI levels in all transplant patients over 2 to 12 months posttransplant on inflammation, subsequent chronicity, later clinical outcomes.Two hundred eighty-six transplanted from January 2013 November...
Mutations in parkin gene (Park2) are linked to early-onset autosomal recessive Parkinson's disease (PD) and young-onset sporadic PD. Park2 knockout (PKO) rodents; however, do not display neurodegeneration of the nigrostriatal pathway, suggesting age-dependent compensatory changes. Our goal was examine dopaminergic (DAergic) system striatum 2 month-old PKO rats order characterize mechanisms that may have occurred within system. The striata form wild type (WT) Long Evans male were assessed for...
Ruptured aneurysm of the anterior mitral leaflet is a rare but devastating complication secondary to aortic valve infective endocarditis. We report case 30‐year‐old male with native endocarditis who was referred us for evaluation worsening heart failure after an initial period responsiveness antibiotics. Detailed two‐dimensional and three‐dimensional transthoracic echocardiography revealed ruptured severe eccentric regurgitation along large vegetation on valve. The patient underwent...
Abstract:: Naturally occurring glycosylated hydroquinone Arbutin, has drawn interest due to its possible function in reducing the risk of neurodegenerative diseases such as Huntington's disease, amyotrophic lateral sclerosis, Parkinson's and Alzheimer's disease. Arbutin is well-known for anti-inflammatory antioxidant properties, which are essential preventing oxidative stress neuroinflammation. Research shown that arbutin might alter important physiological pathways connected protein...
Chemotherapy-induced cardiotoxicity constitutes subclinical myocardial dysfunction, arrhythmias, pericarditis, coronary vasospasm, and significant symptomatic heart failure. Anthracyclines pose higher risk for long-term cardiac with increased incidences of morbidity mortality. Hence, early detection chemotherapy-induced dysfunction may prompt an earlier treatment modification. To evaluate global, longitudinal, radial, circumferential strain changes in adult patients undergoing anthracycline...
Radial artery occlusion (RAO) is a common complication during transradial coronary intervention. Its incidence variably reported in literature and its predictors are not completely understood. In this study, we aimed to define the factors influencing RAO patients undergoing intervention.This was single-center prospective study (October 2018 September 2019) that enrolled 1,754 who were evaluated for 24 hours after Univariate as well multivariate analyses done identify patient procedure...
We describe the images of a 27-year-old man presenting with recurrent syncope due to complete heart block (figure 1). The patient, on further examination, showed ophthalmoplegia, bilateral ptosis 2) and pigmentary retinopathy 3). Kearns-Sayre syndrome (KSS) is rare mitochondrial genetic disorder multisystem involvement. KSS usually presents before age 20 years. triad external opthalmoplegia, retinopathy, cardiac conduction defects are sufficient make confident diagnosis …
The phenotypical profile of cardiovascular malformations in patients with congenital rubella syndrome (CRS) is varied. We aimed to describe the cardiac defects among CRS detected sentinel surveillance India during 2016-22.Sentinel sites enrolled infants suspected based on presence defects, hearing impairment, eye signs, or maternal history febrile rash illness. Suspected cases underwent detailed systemic examination, including echocardiography and serological investigation for rubella....
Abstract There is no FDA-approved medication for methamphetamine (METH) use disorder. New therapeutic approaches are needed, especially people who METH heavily and at high risk overdose. This study used genetically engineered rats to evaluate PARKIN as a potential target knockout, PARKIN-overexpressing, wild-type young adult male Long Evans were trained self-administer doses of using an extended-access self-administration paradigm. Reinforcing/rewarding properties assessed by quantifying...