A5074860490- Pain Mechanisms and Treatments
- Ion Channels and Receptors
- Neuropeptides and Animal Physiology
- Porphyrin and Phthalocyanine Chemistry
- Neuroscience of respiration and sleep
- Receptor Mechanisms and Signaling
- Nicotinic Acetylcholine Receptors Study
- Olfactory and Sensory Function Studies
- Ion channel regulation and function
- Neurobiology and Insect Physiology Research
- DNA and Nucleic Acid Chemistry
- Thermoregulation and physiological responses
- Respiratory and Cough-Related Research
- COVID-19 Clinical Research Studies
- Porphyrin Metabolism and Disorders
- COVID-19 and Mental Health
- Pharmacological Effects of Natural Compounds
- Heart Rate Variability and Autonomic Control
- Nutritional Studies and Diet
- Acupuncture Treatment Research Studies
- Stress Responses and Cortisol
- Veterinary Pharmacology and Anesthesia
- Molecular Sensors and Ion Detection
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cancer, Stress, Anesthesia, and Immune Response
University of Pecs
2012-2024
University of Szeged
2022
Wikimedia Foundation
2022
Hungarian Academy of Sciences
1999-2003
Friedrich-Alexander-Universität Erlangen-Nürnberg
2001
Semmelweis University
1994-1995
University of Graz
1995
Emory University
1993
Capsaicin-sensitive, TRPV1 (transient receptor potential vanilloid 1) receptor-expressing primary sensory neurons exert local and systemic efferent effects besides the classical afferent function. The is considered a molecular integrator of various physico-chemical noxious stimuli. In present study its role was analysed in acute nociceptive tests chronic neuropathy models by comparison wild-type (WT) knockout (KO) mice. formalin-induced nocifensive behaviour, carrageenan-evoked inflammatory...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInteractions of an Electron-Rich Tetracationic Tentacle Porphyrin with Calf Thymus DNANancy E. Mukundan, Gabor Petho, Dabney W. Dixon, Min Sook Kim, and Luigi G. MarzilliCite this: Inorg. Chem. 1994, 33, 21, 4676–4687Publication Date (Print):October 1, 1994Publication History Published online1 May 2002Published inissue 1 October 1994https://pubs.acs.org/doi/10.1021/ic00099a018https://doi.org/10.1021/ic00099a018research-articleACS...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTentacle porphyrins: DNA interactionsLuigi G. Marzilli, Gabor Petho, Mengfen Lin, Min Sook Kim, and Dabney W. DixonCite this: J. Am. Chem. Soc. 1992, 114, 19, 7575–7577Publication Date (Print):September 1, 1992Publication History Published online1 May 2002Published inissue 1 September 1992https://pubs.acs.org/doi/10.1021/ja00045a047https://doi.org/10.1021/ja00045a047research-articleACS PublicationsRequest reuse permissionsArticle...
Quercetin is an abundant flavonoid in nature and used several dietary supplements. Although quercetin extensively metabolized by human enzymes the colonic microflora, we have only few data regarding pharmacokinetic interactions of its metabolites. Therefore, investigated interaction microbial metabolites with xanthine oxidase enzyme. Inhibitory effects five conjugates 23 were examined 6-mercaptopurine substrates (both at 5 μM), employing allopurinol as a positive control....
Alternariol (AOH) is a mycotoxin produced by Alternaria species. In vitro studies suggest the genotoxic, mutagenic, and endocrine disruptor effects of AOH, an increased incidence esophageal cancer has been reported related to higher AOH exposure. Human serum albumin (HSA) most abundant plasma protein in circulation, it able affect toxicokinetic properties numerous xenobiotics. HSA forms stable complexes with several mycotoxins, however, interaction not examined. this study, complex formation...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDNA-tentacle porphyrin interactions: AT over GC selectivity exhibited by an outside binding self-stacking porphyrinNancy E. Mukundan, Gabor Petho, Dabney W. Dixon, and Luigi G. MarzilliCite this: Inorg. Chem. 1995, 34, 14, 3677–3687Publication Date (Print):July 1, 1995Publication History Published online1 May 2002Published inissue 1 July 1995https://pubs.acs.org/doi/10.1021/ic00118a015https://doi.org/10.1021/ic00118a015research-articleACS...
An increasing‐temperature hot plate (ITHP) was introduced to measure the noxious heat threshold (45.3±0.3°C) of unrestrained rats, which reproducible upon repeated determinations at intervals 5 or 30 min 1 day. Morphine, diclofenac and paracetamol caused an elevation following i.p. pretreatment, minimum effective doses being 3, 10 200 mg kg −1 , respectively. Unilateral intraplantar injection VR1 receptor agonist resiniferatoxin (RTX, 0.048 nmol) induced a profound drop innocuous range with...
Abstract Bradykinin can excite C‐polymodal nociceptors and sensitize them to heat it also enhance prostaglandin synthesis, but is unclear whether these effects are causally related. The role of cyclooxygenase products was investigated using two enantiomers the inhibitor flurbiprofen which S(+)‐ more potent than R(–)‐flurbiprofen. Single‐unit activity recorded from mechano‐heat‐sensitive, polymodal C‐fibers in isolated rat skin‐saphenous nerve preparation. pretreatment (10 µ m , 5 min)...
Pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) and its receptors have been shown in the spinal dorsal horn, on capsaicin-sensitive sensory neurons inflammatory cells. The role of PACAP central pain transmission is controversial, no data are available function peripheral nociception. Therefore, aim present study was to analyze effects locally or systemically administered PACAP-38 nocifensive behaviors, inflammatory/neuropathic hyperalgesia afferent firing. Intraplantar...
Abstract Agonists of the TRPV1 receptor excite TRPV1‐expressing polymodal nociceptors that is followed after higher doses by a state diminished responsiveness called desensitization which ensues at two levels: (i) ion channel (TRPV1 desensitization); (ii) nerve endings to all stimuli including noxious heat. The aim was compare these desensitizing actions agonists in rat measuring with an incremental hot/cold plate heat and cold thresholds, i.e. lowest hot highest temperature, respectively,...
Capsaicin antagonists including ruthenium red, capsazepine and iodo-resiniferatoxin (I-RTX) have recently been shown to inhibit the activation by noxious heat of capsaicin receptor (TRPV1) expressed in non-neuronal host cells, natively, cultured dorsal root ganglion cells. Noxious has release immunoreactive calcitonin gene-related peptide (iCGRP) from isolated rat skin. In this model, I-RTX as well 10 microM caused no alteration iCGRP at 32 degrees C themselves whereas 100 doubled it...