A5101417365- Plant-based Medicinal Research
- Pharmacological Effects of Natural Compounds
- Traditional Chinese Medicine Analysis
- Traditional Chinese Medicine Studies
- Bioactive Natural Diterpenoids Research
- melanin and skin pigmentation
- Natural product bioactivities and synthesis
- Chemical synthesis and alkaloids
- Pharmacovigilance and Adverse Drug Reactions
- Analytical Chemistry and Chromatography
- Platelet Disorders and Treatments
- Inflammatory mediators and NSAID effects
- Seaweed-derived Bioactive Compounds
- Cancer, Hypoxia, and Metabolism
- Enzyme Production and Characterization
- Chromatography in Natural Products
- Nanocluster Synthesis and Applications
- Metabolomics and Mass Spectrometry Studies
- Synthesis and Biological Evaluation
- Estrogen and related hormone effects
- Bioactive natural compounds
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Phenothiazines and Benzothiazines Synthesis and Activities
- Nanoplatforms for cancer theranostics
- Analytical Methods in Pharmaceuticals
Shanghai Jiao Tong University
2022-2024
Shanghai First People's Hospital
2022-2023
North China University of Water Resources and Electric Power
2023
Tongji University
2022
Sun Yat-sen University
2007-2009
Sun Yat-sen Memorial Hospital
2007-2009
Guangzhou Psychiatric Hospital
2005
Guangdong 999 Brain Hospital
2005
Purpose: Alisma orientale (AO, (Sam). Juzep) has been widely employed for the treatment of macular edema (ME) in traditional Chinese medicine due to its renowned water-relief properties. Nonetheless, comprehensive investigation AO alleviating ME remained unexplored. This study aims identify active components that target eye and investigate pharmacological effects mechanisms on ME. Methods: The commenced with UPLC-Triple-TOF/MS analysis primary constituents AO. Zebrafish tissues were then...
Theranostics, by integrating diagnosis and therapy on a single platform, enables real-time monitoring of tumors during treatment. To improve the accuracy tumor diagnosis, fluorescence photoacoustic imaging modalities can complement each other to achieve high resolution deep penetration depth. Despite superior performance, biodegradability theranostic agents plays critical role in enhancing nanoparticle excretion reducing chronic toxicity, which is essential for clinical applications. Herein,...
Abstract This study aimed to explore the substance basis and mechanisms of Shen-qi-wang-mo Granule (SQWMG), a traditional Chinese medicine prescription that had been clinically utilized treat retinal vein occlusion (RVO) for 38 years. Components in SQWMG were analyzed by UPLC-Triple-TOF/MS total 63 components identified with ganoderic acids (GA) being largest proportion. Potential targets active retrieved from SwissTargetPrediction. RVO-related acquired related disease databases. Core...
Background: Schisandrol A (Sch A) is the main active ingredient of Schisandra chinensis (Turcz.) Baill. Our previous study showed that Sch has anti-pulmonary fibrosis (PF) activity, but its metabolic-related mechanisms action are not clear. Methods: Here, we explored therapeutic on PF by ultra-high performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS) metabolomics approach and network analysis. The metabolites in mice (bleomycin + high-dose group) plasma were...
In our previous study, several bicyclol (BIC) metabolites were found to possess higher solubility, security, and efficacy than the parent drug. However, further research can't be conducted without monomeric metabolites. current a highly efficient preparative approach for six BIC-active from Sprague-Dawley (SD) rat urine was developed. First, 1000 mL of purified concentrated 50 using microporous resin. Second, middle chromatogram isolated (MCI) GEL®CHP20P adsorbent used create low-pressure...
The heat and moisture transfer process in deformable porous media commonly exists material drying, solid waste treatment, bioengineering, so on. is accompanied by deformation of the skeleton pore interface structure, which limits rate affects quality. Microwave ultrasound are main representatives reinforcement technology. However, as decreases, energy utilization efficiency microwaves decreases significantly. Based on experimental theoretical methods, enhancement mechanism studied, provides...
The Yiqi Qubai (YQ) formula is a hospital preparation for treating vitiligo in China that has had reliable efficacy decades. consists of four herbs; however, the extraction process to produce obsolete and active ingredients mechanisms remain unknown. Therefore, this paper, fingerprints were combined with chemometrics method screen high-quality herbs YQ standard decoction (YQD). Then, YQD procedure was optimized using response surface methodology. A total 44 chemical constituents, as well 36...
Abstract Yiqi Qubai Decoction (YQD) is composed of four herbs, namely, Astragalus propinquus Schischkin, Akebiae Fructu, Leonuri Fructus, and Caragana Sinica Roots. For decades, the decoction has been utilized in form granules for treatment vitiligo China, with a remarkable curative result widespread recognition among patients. However, chemical contents active substances YQD absorption into plasma, as well its mechanism treatment, remain unknown. This problem was solved based on serum...