A5034387637- Essential Oils and Antimicrobial Activity
- Phytochemical compounds biological activities
- Bioactive Natural Diterpenoids Research
- Ethnobotanical and Medicinal Plants Studies
- Wound Healing and Treatments
- Traditional and Medicinal Uses of Annonaceae
- Natural product bioactivities and synthesis
- Insect Pest Control Strategies
- Fungal Biology and Applications
- Fungal Plant Pathogen Control
- Signaling Pathways in Disease
- Mycorrhizal Fungi and Plant Interactions
- Chemical synthesis and alkaloids
- Cancer therapeutics and mechanisms
- Antibiotic Resistance in Bacteria
- African Botany and Ecology Studies
- Marine Sponges and Natural Products
- Plant and animal studies
- Plant Pathogens and Fungal Diseases
- Toxin Mechanisms and Immunotoxins
- Lepidoptera: Biology and Taxonomy
- Species Distribution and Climate Change
- Lichen and fungal ecology
- Biocrusts and Microbial Ecology
- Garlic and Onion Studies
Royal Botanic Gardens, Kew
2014-2025
Butterfly Conservation
2019
University of Edinburgh
2006
Societal Impact Statement Plants and fungi have provided, or inspired, key pharmaceuticals for global health challenges, including cancer, heart disease, dementia, malaria, are valued as traditional medicines worldwide. Global demand medicinal plants has threatened certain species, contributing to biodiversity loss depletion of natural resources that important the humanity. We consider evolving role in healthcare new challenges human arise. present current emerging scientific approaches,...
For some professionally, vocationally, or technically oriented careers, curricula delivered in higher education establishments may focus on teaching material related to a single discipline. By contrast, multidisciplinary, interdisciplinary, and transdisciplinary (MITT) results improved affective cognitive learning critical thinking, offering learners/students the opportunity obtain broad general knowledge base. Chemistry is discipline that sits at interface of science, technology,...
Antibacterial activity is a common and highly studied property of plant secondary metabolites. Despite the extensive literature focusing on identifying novel antibacterial metabolites, little work has been undertaken to examine variation in levels any species. Here, we used large-scale sampling leaves plant, wild garlic (Allium ursinum L.), assembling set tissue extracts from 168 plants, with 504 collected analysed. We assayed for against Bacillus subtilis LC-MS carry out chemometric...
Moths form an important part of Scotland's biodiversity and up-to-date assessment their status is needed given value as a diverse species-rich taxon, with various ecosystem roles, the known decline moths within Britain. We use long-term citizen-science data to produce species-level trends multi-species indicators for in Scotland, assess population (abundance) distribution (occupancy) changes. Abundance Scotland are produced using Rothamsted Insect Survey count data, and, first time,...
Abstract Fungi produce a vast number of secondary metabolites that shape their interactions with other organisms and the environment. Characterizing genes underpinning metabolite synthesis is therefore key to understanding fungal evolution adaptation. Lichenized fungi represent almost one-third Ascomycota diversity boast impressive repertoires. However, most lichen biosynthetic have not been linked products. Here we used metagenomic sequencing survey gene families associated production...
Abstract Acinetobacter baumannii is a Gram-negative priority pathogen that can readily overcome antibiotic treatment through range of intrinsic and acquired resistance mechanisms. Treatment carbapenem-resistant A. largely relies on the use colistin in cases where other options have been exhausted. However, emergence against this last-line drug has significantly increased amongst clinical strains. In study, we identify phytochemical kaempferol as potentiator activity. When administered...
Complete pipeline for system-level of biological systems, from indivituals to ecosystems, using only metabolite data.
An aromatic alkaloid-rich 'absolute' extract from Vepris gossweileri inhibited Saccharomyces cerevisiae at 62.5 μg.mL-1 and Bacillus subtilis 500 μg.mL-1. A loss of activity upon fractionation indicated possible synergistic effects. Three new acridones, gossweicridone (3), B (4) C (5) known compounds the were inactive. Combinations showed that a sub-fraction containing mixtures minor with (Ε)-caryophyllene augmented by 50-folds, MIC values 19.6 for S. 375.0 B. subtilis, demonstrating potent...
Eleven undescribed triterpenoids (pentandrucines A to K) were isolated from the n-hexane extract of stem bark Chisocheton pentandrus (Blanco) Merr. These comprised ten dammarane-type and one apotirucallane-type triterpenoid. Additionally, two triterpenoids, four tirucallane-type also isolated. The chemical structures pentandrucine A-K, fully elucidated using 1D 2D-NMR, high resolution MS. All compounds evaluated for cytotoxic activity against MCF-7 breast cancer cells in vitro. Melianodiol...
Reported herein is an anti-HIV monochlorinated compound, 1β-acetoxy-3β-chloro-5α,6α-dihydroxycrotocascarin L (1), of the rare crotofolane diterpenoid class. Compound 1, a suspected artifact extraction, along with previously undescribed 11β-acetoxycrotocascarin (2) and known crotocascarin K (3), were isolated from bark Croton megalocarpus, Kenyan oil-producing seed crop. Compounds 1 3 inhibited HIV-1 replication IC50 values 28 5.5 nM, respectively. Furthermore, both compounds lacked...