Juan D. Martínez

ORCID: 0000-0002-3042-7633
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About
Contact & Profiles
Research Areas
  • COVID-19 Clinical Research Studies
  • Long-Term Effects of COVID-19
  • Hippo pathway signaling and YAP/TAZ
  • Pluripotent Stem Cells Research
  • Congenital heart defects research
  • Developmental Biology and Gene Regulation
  • Stroke Rehabilitation and Recovery
  • Climate Change and Health Impacts
  • SARS-CoV-2 and COVID-19 Research
  • Immunotherapy and Immune Responses
  • Cardiac Health and Mental Health
  • Public Policy and Governance
  • Multiple Sclerosis Research Studies
  • Coastal and Marine Management
  • Peripheral Neuropathies and Disorders
  • Vagus Nerve Stimulation Research
  • Cancer-related gene regulation
  • Neurogenesis and neuroplasticity mechanisms
  • Protein Degradation and Inhibitors
  • Parkinson's Disease Mechanisms and Treatments
  • RNA Research and Splicing
  • Genetic Neurodegenerative Diseases
  • Infectious Aortic and Vascular Conditions
  • Renal and related cancers
  • Libraries, Manuscripts, and Books

The University of Texas Health Science Center at Houston
2024-2025

Universidad de La Sabana
2020-2024

Secretaría de Salud de Bogotá
2022-2024

Sociedad de Biología de Chile
2022

Antares Pharma (United States)
2021

Institut de Biologia Molecular de Barcelona
2018-2020

Chilean Air Force
2001

The growth and evolutionary expansion of the cerebral cortex are defined by spatial-temporal production neurons, which itself depends on decision radial glial cells (RGCs) to self-amplify or switch neurogenic divisions. mechanisms regulating these RGC fate decisions still incompletely understood. Here we describe a novel evolutionarily conserved role canonical BMP transcription factors SMAD1/5 in controlling neurogenesis during corticogenesis. Reducing expression both SMAD1 SMAD5 neural...

10.1242/dev.187005 article EN publisher-specific-oa Development 2020-01-01

Introducción: el ataque cerebrovascular isquémico (ACVi) es la segunda causa de muerte en Colombia. Se estimó que los costos asociados al ACVi podrían alcanzar COP 5000 millones durante 2019. Objetivo: describir médicos directos pacientes sufren una institución Bogotá 2020. Metodología: estudio corte transversal analiza atención hospitalaria adultos sufrieron un compararon costos, estancia y desenlaces clínicos recibieron trombólisis frente aquellos no recibieron. Resultados: relacionados...

10.22379/anc.v40i1.873 article ES cc-by-nc-nd Acta neurológica colombiana 2024-01-23

Dementias constitute a group of degenerative diseases that affect different domains within human cognition. While the usual course is chronically progressive, small patients develops subacute deterioration in months, an entity called rapidly progressive dementia. For these patients, approach based on considering reversible etiologies mandatory, and its diagnosis must be taken into consideration not only immunocompromised by immunodeficiency virus (HIV) but also with other causes...

10.22354/24223794.1067 article EN Infectio 2022-07-31

Abstract The growth and evolutionary expansion of the cerebral cortex are defined by spatial-temporal production neurons, which itself depends on decision radial glial cells (RGCs) to self-amplify or switch neurogenic divisions. mechanisms regulating these RGC fate decisions still incompletely understood. Here we describe a novel evolutionarily conserved role canonical BMP transcription factors SMAD1/5 in controlling neurogenesis during corticogenesis. Reducing expression both SMAD1 SMAD5...

10.1101/558486 preprint EN cc-by-nc-nd bioRxiv (Cold Spring Harbor Laboratory) 2019-02-22

Infectious meningoencephalitis (IME) is a neurological emergency with significant rate of morbidity and mortality. The Biofire FilmArray® meningitis/encephalitis (FAME) panel for testing in cerebrospinal fluid (CSF) has proven to be valuable tool the aetiological diagnosis IME, facilitating targeted antimicrobial therapy. aim determine impact FAME on therapeutic decisions patients suspected IME first 24 hours clinical assessment.This descriptive observational study that comments...

10.33588/rn.7704.2023082 article ES Revista de Neurología 2023-01-01

Abstract Basic HLH proteins heterodimerize with class I HLH/E to promote transcription. Here we show that E differentially co-operate proneural bHLH transcription factors sharpening their neurogeneic activity. We find inhibiting BMP signaling or its target ID2, in the chick embryo spinal cord, impairs neuronal production from progenitors expressing ATOH1/ASCL1, but less severely NEUROG1/2/PTF1a. define mechanisms of this differential response as a dual co-operation proteins. synergize when...

10.1101/301093 preprint EN cc-by bioRxiv (Cold Spring Harbor Laboratory) 2018-04-14

Introducción: La enfermedad por coronavirus 2019 (COVID-19) en enfermos renales crónicos (ERC) terapia de reemplazo renal (TRR), hemodiálisis (HD), diálisis peritoneal (DP) y trasplante (Tx) tiene elevada mortalidad, con datos clínicos epidemiológicos Latinoamérica aún limitados.Métodos: Estudio nacional observacional, multicéntrico, obtenido la fuerza tarea contra COVID-19 Chile (FUTAC Renal), evaluando epidemiología resultados mayores los pacientes ERC TRR, que desarrollaron el año...

10.24875/nefro.21000045 article ES cc-by-nc-nd Nefrología Latinoamericana 2021-12-10
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