A5072913629- Mitochondrial Function and Pathology
- Autophagy in Disease and Therapy
- Lysosomal Storage Disorders Research
- Neuroscience and Neuropharmacology Research
- Plant Virus Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- ATP Synthase and ATPases Research
- Calcium signaling and nucleotide metabolism
- Plant and Fungal Interactions Research
- Genetic Neurodegenerative Diseases
- Tryptophan and brain disorders
- Biochemical Acid Research Studies
- Nanoparticles: synthesis and applications
- Peroxisome Proliferator-Activated Receptors
- Plant Disease Management Techniques
- Amino Acid Enzymes and Metabolism
- Histone Deacetylase Inhibitors Research
- Cannabis and Cannabinoid Research
- Pharmacological Effects of Natural Compounds
- Bacteriophages and microbial interactions
- Neurological Disease Mechanisms and Treatments
- Sphingolipid Metabolism and Signaling
- Poxvirus research and outbreaks
- Metabolism and Genetic Disorders
- Plant Molecular Biology Research
Instituto de Biología Funcional y Genómica
2014-2023
Universidad de Salamanca
2014-2023
Instituto de Salud Carlos III
2020-2021
Instituto de Biomedicina de Valencia
2021
Universitat de València
2021
Biomedical Research Networking Center on Neurodegenerative Diseases
2021
Instituto de Investigación Biomédica de Salamanca
2015-2021
Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable
2018-2021
Escuela Nacional de Sanidad
2020
Consejo Superior de Investigaciones Científicas
2016
Significance Neurons depend on oxidative phosphorylation for survival, whereas astrocytes do not. Mitochondrial respiratory chain (MRC) complexes can be organized in higher structures called supercomplexes, which dictate MRC electron flux and energy efficiency. Whether the specific metabolic shapes of neurons are determined by organization is unknown. Here, we found that, astrocytes, most complex I free, resulting poor mitochondrial respiration but high reactive oxygen species (ROS)...
Having direct access to brain vasculature, astrocytes can take up available blood nutrients and metabolize them fulfil their own energy needs deliver metabolic intermediates local synapses
Upregulation of fatty acid synthase (FASN) is a common event in cancer, although its mechanistic and potential therapeutic roles are not completely understood. In this study, we establish key role FASN during transformation. required for eliciting the anaplerotic shift Krebs cycle observed cancer cells. However, main to consume acetyl-CoA, which unlocks isocitrate dehydrogenase (IDH)-dependent reductive carboxylation, producing power necessary quench reactive oxygen species (ROS) originated...
CLN7 neuronal ceroid lipofuscinosis is an inherited lysosomal storage neurodegenerative disease highly prevalent in children. CLN7/MFSD8 gene encodes a membrane glycoprotein, but the biochemical processes affected by CLN7-loss of function are unexplored thus preventing development potential treatments. Here, we found, Cln7∆ex2 mouse model disease, that failure autophagy causes accumulation structurally and bioenergetically impaired mitochondria. In vivo genetic approach reveals elevated...
Using mouse embryonic fibroblasts (MEFs) from DJ1-knockout mice, in the present study, we show that DJ1, by binding with Foxo3a (forkhead box O3a), transcriptionally activates pink1 (phosphatase and tensin homologue deleted on chromosome 10-induced protein kinase-1) gene. Moreover, demonstrate that, promoting expression, DJ1 represses rate of glycolysis cell proliferation.
Cells naturally produce mitochondrial reactive oxygen species (mROS), but the in vivo pathophysiological significance has long remained controversial. Within brain, astrocyte-derived mROS physiologically regulate behaviour and are produced at one order of magnitude faster than neurons. However, whether neuronal abundance differentially impacts on is unknown. To address this, we engineered genetically modified mice to down modulate levels neurons vivo. Whilst no alterations motor coordination...
The Arabis mosaic virus (ArMV) is one of the causative agent grapevine fanleaf disease, most widespread and damaging viral diseases grapevine. Recently, ArMV has been detected in Spanish vineyards, its determination molecular characterization was undertaken. To this aim, nucleotide sequence genomic RNAs 1 2 first isolate infecting Spain (ArMV-DU13) determined. ArMV-DU13 sequences were compared to corresponding other isolates ArMV, or nepoviruses. divergent genes among X1 VPg on RNA 1, 2A...
The neuronal ceroid lipofuscinoses (NCLs) are a family of monogenic life-limiting pediatric neurodegenerative disorders collectively known as Batten disease 1 . Although genetically heterogeneous 2 , NCLs share several clinical symptoms and pathological hallmarks such lysosomal accumulation lipofuscin astrogliosis 2,3 CLN7 belongs to group that present in late infancy 4–6 and, whereas CLN7/MFSD8 gene is encode membrane glycoprotein 4,7–9 the biochemical processes affected by CLN7-loss...