A5010273392- Immune Cell Function and Interaction
- CAR-T cell therapy research
- interferon and immune responses
- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- vaccines and immunoinformatics approaches
- Immune Response and Inflammation
- Protein Degradation and Inhibitors
- Immunotherapy and Immune Responses
- Social and Educational Sciences
- Financial Reporting and Valuation Research
- Welding Techniques and Residual Stresses
- Microstructure and Mechanical Properties of Steels
- Cytokine Signaling Pathways and Interactions
- Nanowire Synthesis and Applications
- Hydrogen embrittlement and corrosion behaviors in metals
- RNA regulation and disease
- Atherosclerosis and Cardiovascular Diseases
- Salivary Gland Disorders and Functions
- Inflammasome and immune disorders
- Occupational Health and Safety Research
- Multiple Sclerosis Research Studies
- Market Dynamics and Volatility
- Risk and Portfolio Optimization
- Maternal and fetal healthcare
Memorial Sloan Kettering Cancer Center
2019-2023
Karolinska Institutet
2009-2022
Karolinska University Hospital
2018-2022
Ro52/Trim21 is targeted as an autoantigen in systemic lupus erythematosus and Sjögren's syndrome. Polymorphisms the Ro52 gene have been linked to these autoimmune conditions, but molecular mechanism by which may promote development of diseases has not explored. To address this issue, we generated Ro52-null mice (Ro52−/−), appear phenotypically normal if left unmanipulated. However, Ro52−/− develop severe dermatitis extending from site tissue injury induced ear tags. The affected further...
Combination of a CAR and chimeric costimulatory receptor augments cytotoxicity durability T cells elimination antigen-low tumors.
Patients with systemic lupus erythematosus (SLE) and primary Sjögren's syndrome (pSS) are typically characterized by the presence of autoantibodies an IFN-signature. The strength IFN-signature positively correlates disease severity, suggesting that type I IFNs active players in these diseases. BAFF is a cytokine critical for development proper selection B cells, targeting has emerged as successful treatment strategy SLE. Previous reports have suggested expression directly induced IFNs, but...
Tripartite-motif 21 (TRIM21) is an E3 ubiquitin ligase that regulates innate immune responses by ubiquitinating IFN regulatory factors (IRFs). TRIM21 mainly found in hematopoietic cells which its expression induced IFNs during viral. infections and systemic autoimmune diseases such as lupus erythematosus Sjögren's syndrome. However, the exact molecular mechanism of Trim21 gene regulated unknown. In this study, we demonstrate induce via IRFs IFN-α IFN-β are most potent inducers Trim21. A...
TRIM21 is an interferon-stimulated E3 ligase that controls the activity of pattern-recognition signaling via ubiquitination interferon regulatory factors and DDX41. Previous studies on role in innate immune responses have yielded contradictory results, suggesting cell specific. Here, we report bone-marrow-derived macrophages (BMDMs) generated from Trim21-/- mice reduced expression mature macrophage markers. Reflecting their differentiation response to colony-stimulating factor (M-CSF), BMDMs...
Abstract Systemic autoimmune diseases are characterized by the overexpression of type I IFN stimulated genes, and accumulating evidence indicate a role for IFNs in these diseases. However, underlying mechanisms this still poorly understood. To explore regulated miRNAs systemic disease, we cellular expression during both acute chronic responses. We identified T cell‐specific reduction miR‐31‐5p levels, after intramuscular injection IFNβ patients with Sjögren's syndrome (SjS). interrogate...
Objective: To evaluate the frequency of uterine rupture following induction labor in women with a previous cesarean section. Misoprostol was compared to other methods induction.
Background: Interleukin-7 (IL-7) is a non-redundant cytokine for T-cell development and survival. The IL-7 signaling pathway has been genetically functionally associated with several autoimmune diseases including multiple sclerosis (MS). Objective: objective of this paper to elucidate the effect widely used immunomodulatory MS therapy interferon beta (IFNβ) on homeostasis. Methods: Swedish patients were screened concentration in serum blood cell counts. receptor alpha chain (IL-7Rα)...
Abstract Melanoma tumors are highly metastatic partly due to the ability of melanoma cells transition between invasive and proliferative states. However, mechanisms underlying this plasticity still not fully understood. To identify new epigenetic regulators plasticity, we combined data mining, tumor models, proximity proteomics, CUT&RUN sequencing. We focus on druggable family bromodomain readers TRIM28 as a regulator plasticity. find that promotes expression pro‐invasive genes controls...
<h3>Background and objectives</h3> Autoimmune disease can arise when the immune system is overactive in response to a trigger. This results an overproduction of proinflammatory cytokines type I interferons (IFNs). The latter associated with pathology several systemic autoimmune diseases such as lupus erythematosus (SLE) primary Sjögren9s syndrome (pSS). In this study authors wanted identify interferon signature genes that contribute pathogenesis pSS. To do so, did gene expression profiling...
The introduction of immune checkpoint blockade has revolutionized the treatment metastatic melanoma 1 . However, 40-60% patients with do not respond to blockade, and a significant fraction acquire resistance 2,3 This resilience aggressiveness tumors is partly due their ability switch between invasive proliferative states 4,5 transition phenotypic indicates that phenotype switching occurs through reversible epigenetic mechanisms rather than by acquisition mutations 6,7 Identifying underlie...
<h3>Background</h3> Chimeric antigen receptors (CARs) engage independently of HLA and enable sustained T cell proliferation when they are endowed with both activating costimulatory functions. While remission rates have been noticeably elevated in numerous clinical trials targeting CD19, CD22 or BCMA, relapses common. One the several underlying relapse mechanisms is escape, which refers to a relapsing tumor that either negative for targeted expresses latter at low level. Failure eliminate...