A5037539046- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Soil Management and Crop Yield
- Advancements in Semiconductor Devices and Circuit Design
- Tree-ring climate responses
- Biochemical Analysis and Sensing Techniques
- Biosimilars and Bioanalytical Methods
- Nanowire Synthesis and Applications
- Viral Infectious Diseases and Gene Expression in Insects
- Virus-based gene therapy research
- Immune Cell Function and Interaction
- Soil Carbon and Nitrogen Dynamics
- Ecology and Vegetation Dynamics Studies
- Crop Yield and Soil Fertility
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Plant Water Relations and Carbon Dynamics
- Ion Channels and Receptors
Amsterdam UMC Location Vrije Universiteit Amsterdam
2024
Cancer Center Amsterdam
2024
Amsterdam University Medical Centers
2021-2024
Technical University of Denmark
2019-2021
Vrije Universiteit Amsterdam
2021
Agricultural University of Athens
2008
Combination of a CAR and chimeric costimulatory receptor augments cytotoxicity durability T cells elimination antigen-low tumors.
Abstract Adoptive cell therapy (ACT) has shown promising results in cancer treatment, however, achieving effective ex vivo expansion of potent, functionally active, and cytotoxic T cells remains challenging. To overcome this, we loaded the engineered cytokine Neoleukin-2/15 (Neo2/15) on our recently established artificial antigen-presenting scaffolds (Ag-scaffolds) to expand antigen-specific cells. Neo2/15 selectively binds IL-2Rβ/γ receptors, enhancing CD8 + proliferation while limiting...
Little is known about the involvement of type 2 immune response-promoting intestinal tuft cells in metabolic regulation. We here examined temporal changes small cell number and activity response to high-fat diet-induced obesity mice investigated relation whole-body energy metabolism phenotype intestine epididymal white adipose tissue. Intake high fat diet resulted a reduction overall numbers epithelial reduced expression markers Il25 Tslp . Amongst >1,700 diet-regulated transcripts...
The past decades have illustrated the power of T-cell engineering in development new and successful cell therapies, such as chimeric antigen receptor (CAR) T-cells. Despite clinical success hematological malignancies, it also becomes increasingly clear that additional will be required to improve efficacy safety expand application solid tumors. Engineering is most often achieved by viral delivery transgenes, however, vector capacity limitations make efficient reproducible generation multi...
ABSTRACT Conservation tillage has been widely applied to reduce intensive agriculture consequences such as erosion, soil degradation, water pollution, loss of organic matter, and high production cost. This study compares conventional cultivation conservation winter cereals (wheat) in an experimental field (1.0 ha) clay structure central Greece. The interventions for the treatment included ploughing, harrowing, seeding, while only seeding spraying (no-tillage). During 2-year experiment, fuel...