A5103242181- Tissue Engineering and Regenerative Medicine
- Pluripotent Stem Cells Research
- Cholinesterase and Neurodegenerative Diseases
- Alzheimer's disease research and treatments
- Nerve injury and regeneration
- Neurogenetic and Muscular Disorders Research
- Neuroscience and Neural Engineering
- CRISPR and Genetic Engineering
- Bone Tissue Engineering Materials
- Medicinal Plants and Neuroprotection
- Bone and Dental Protein Studies
- RNA Interference and Gene Delivery
- Reproductive Biology and Fertility
- Orthopaedic implants and arthroplasty
- Virus-based gene therapy research
- Tryptophan and brain disorders
University of Victoria
2017-2020
International Collaboration On Repair Discoveries
2019
University of British Columbia
2019
Cellular transdifferentiation changes mature cells from one phenotype into another by altering their gene expression patterns. Manipulating of transcription factors, proteins that bind to DNA promoter regions, regulates the levels key developmental genes. Viral delivery factors can efficiently reprogram somatic cells, but this method possesses undesirable side effects, including as mutations leading oncogenesis. Using protein transduction domains (PTDs) fused deliver exogenous serves an...
Alzheimer's disease (AD) accounts for 80% of all dementia cases, making it the most common form dementia. Aging serves as main risk factor AD, but early onset AD can also occur in individuals younger than 65 years. results from progressive neurodegeneration leading to dysfunctional synaptic transmission brain. The cascade hypothesis states that amyloid precursor protein (APP) metabolism becomes impaired either by mutation or an interleukin-mediated stress response injury, resulting splicing...
This study evaluated the gene expression profile of human adipose-derived stem cells (hASCs) grown on Biosilicate® /F18 glass (BioS-2P/F18) scaffolds. hASCs were cultured using osteogenic medium (control), scaffolds, and their ionic extract. We observed that ALP activity was higher in BioS-2P/F18 scaffolds than with extract or day 14. Moreover, dissolution product group control exhibited deposited calcium, which peaked 21. Gene profiles cell vitro RT2 Profiler polymerase chain reaction (PCR)...
Background on the relationship between meditation/yoga practice and its effect Alzheimer's disease (AD): Dementia refers to a variety of conditions that affect normal function brain, leading symptoms like memory loss, issues with problem solving, difficulty in processing thoughts disordered language (McKhann et al., 2011). AD serves as one major causes dementia it is responsible for ~80% cases according Association. affects ability neurons, information transmitting cells both peripheral...
You have accessJournal of UrologyInfertility: Basic Research & Pathophysiology (PD39)1 Sep 2021PD39-07 GENERATION OF PERITUBULAR MYOID-LIKE CELLS FROM HUMAN INDUCED PLURIPOTENT STEM Meghan Robinson, Ryan Flannigan, and Luke Witherspoon RobinsonMeghan Robinson More articles by this author , FlanniganRyan Flannigan WitherspoonLuke View All Author Informationhttps://doi.org/10.1097/JU.0000000000002049.07AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints...
You have accessJournal of UrologyInfertility: Basic Research & Pathophysiology (PD39)1 Sep 2021PD39-10 A XENO-FREE CULTURE METHOD FOR THE IN VITRO EXPANSION OF HUMAN SPERMATOGONIAL STEM CELLS Meghan Robinson, Ryan Flannigan, and Luke Witherspoon RobinsonMeghan Robinson More articles by this author , FlanniganRyan Flannigan WitherspoonLuke View All Author Informationhttps://doi.org/10.1097/JU.0000000000002049.10AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints...