A5007903930- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Retinal and Macular Surgery
- Food Allergy and Anaphylaxis Research
- Glaucoma and retinal disorders
- Diet, Metabolism, and Disease
- Nutritional Studies and Diet
- Nanoplatforms for cancer theranostics
- Molecular Biology Techniques and Applications
- Nanoparticle-Based Drug Delivery
- Immune Cell Function and Interaction
- Retinal Diseases and Treatments
- Allergic Rhinitis and Sensitization
- Tissue Engineering and Regenerative Medicine
- Pediatric health and respiratory diseases
- Sinusitis and nasal conditions
- Lipid metabolism and disorders
- Transgenic Plants and Applications
- Head and Neck Surgical Oncology
- Endoplasmic Reticulum Stress and Disease
- Meningioma and schwannoma management
- Retinal Development and Disorders
- Traumatic Ocular and Foreign Body Injuries
- Facial Trauma and Fracture Management
- Ophthalmology and Eye Disorders
University of Siena
2022-2025
Glioblastoma multiforme (GBM) is the most aggressive primary tumor of central nervous system and diagnosis often dismal. GBM pharmacological treatment strongly limited by its intracranial location beyond blood-brain barrier (BBB). While Temozolomide (TMZ) exhibits best clinical performance, still less than 20% crosses BBB, therefore requiring administration very high doses with resulting unnecessary systemic side effects. Here, we aimed at designing new negative temperature-responsive gel...
Follicle-associated epithelium (FAE) covering the lymphoid follicles of Peyer’s patches (PPs) plays a central role in mucosal immunity. Here, we investigated FAE-derived intrafollicular epithelial bodies (IFEBs) that apparently detach from FAE and sink deep into tissue PPs. Analysis rabbit PP was carried out by variety microscopy immunohistochemistry techniques using panel specific antibodies to determine nature IFEBs. IFEBs displayed typical features FAE, with cytokeratin (CK)+ cells...
Overconsumption of an unbalanced diet and overweight, leading to insulin resistance, dyslipidemia, hepatic steatosis, cardiovascular diseases obesity, is nowadays a worldwide health issue, with different patterns metabolic disturbances in the young adult popula-tions, both gender. Preclinical models that closely mimic gradual weight gain occurs humans upon consumption “western-type” (WD) are great interest. In particular, diet-induced obesity (DIO) model C57BL/6J mouse sub-strain often used...
The spina musculi recti lateralis (SMRL) is often visible along the lateral rim of superior orbital fissure (SOF). Aim this study to characterize SMRL morphology and topography relative known bony landmarks.Orbits from 291 adult dry skulls 60 CT scans were analyzed measure distance between SOF or inferior fissures (IOF) as well its height, width orientation. Processes other than SMRLs also recorded. Fetal observed for comparison with samples.Forty-one per cent orbits on 43.3% by showed an...
Consuming an unbalanced diet and being overweight represent a global health problem in young people adults of both sexes, may lead to metabolic syndrome. The diet-induced obesity (DIO) model the C57BL/6J mouse substrain that mimics gradual weight gain humans consuming "Western-type" (WD) is great interest. This study aims characterize this animal model, using high-frequency ultrasound imaging (HFUS) as complementary tool longitudinally monitor changes liver, heart kidney. Long-term WD...
Abstract Accumulation of lipids in the liver characterizes metabolic dysfunction-associated steatotic disease (MASLD), most prevalent chronic worldwide. As injury progresses to steatohepatitis (MASH), MASLD can predispose individuals cirrhosis and hepatocellular carcinoma. Here, we characterized first knockout mouse model for mitogen-activated protein kinase 15 (MAPK15) revealed its critical role controlling lipid homeostasis liver. Indeed, Mapk15 -/- mice exhibited a MASLD-like phenotype,...
All allergic responses to food indicate failure of immunological tolerance but it is unclear why cow’s milk and egg (CME) allergies resolve more readily than reactivity peanuts (PN). We sought identify differences between PN CME through constitutive immune status cognate non-cognate antigens. Children with confirmed allergy (n=6), (n=18) non-allergic (NA) (n=8) controls were studied. Constitutive secretion cytokines was tested in plasma unstimulated mononuclear cell (PBMNC) cultures. Blood...
All allergic responses to food indicate the failure of immunological tolerance, but it is unclear why cow's milk and egg (CME) allergies resolve more readily than reactivity peanuts (PN). We sought identify differences between PN CME through constitutive immune status cognate non-cognate antigens. Children with confirmed allergy (n = 6) 18) non-allergic (NA) 8) controls were studied. Constitutive secretion cytokines was tested in plasma unstimulated mononuclear cell (PBMNC) cultures. Blood...