A5028420124- Respiratory Support and Mechanisms
- Cardiac Arrest and Resuscitation
- Renal Transplantation Outcomes and Treatments
- Neonatal Respiratory Health Research
- Trauma and Emergency Care Studies
- Intensive Care Unit Cognitive Disorders
- Bone health and osteoporosis research
- Bone health and treatments
- Airway Management and Intubation Techniques
- Pharmacological Effects and Toxicity Studies
- Sarcoma Diagnosis and Treatment
- Nanoparticle-Based Drug Delivery
- Sepsis Diagnosis and Treatment
- Immune Response and Inflammation
- Restraint-Related Deaths
- Oral and gingival health research
- Myasthenia Gravis and Thymoma
- Bone Metabolism and Diseases
- Renal Diseases and Glomerulopathies
- Urinary Tract Infections Management
- Musculoskeletal synovial abnormalities and treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Parkinson's Disease and Spinal Disorders
- Neurological Complications and Syndromes
- Amyloidosis: Diagnosis, Treatment, Outcomes
Florida College
2025
University of Florida
2025
Rush Children's Hospital
2024
Rush University
2024
All India Institute of Medical Sciences
2008-2023
Institute of Life Sciences
2014-2021
Rush University Medical Center
2021
Manipal Academy of Higher Education
2015-2020
SUNY Upstate Medical University
2014-2019
Loyola University Medical Center
2018-2019
Background: Acute kidney injury (AKI) is one of the commonest manifestations end-organ damage associated with birth asphyxia.Objective: To evaluate glomerular and tubular dysfunction in neonates moderate to severe asphyxia.Design: Prospective cohort study.Setting: Neonatal unit a teaching hospital.Methods: Subjects were inborn ⩾34 completed weeks gestation an APGAR score <7 at 1 min after birth. Renal function tests including serum electrolytes measured daily until 96 hrs life along urinary...
<h3>Importance</h3> Improper mechanical ventilation settings can exacerbate acute lung injury by causing a secondary ventilator-induced injury. It is therefore important to establish the mechanism which ventilator induces develop protective strategies. has been postulated that of result heterogeneous, elevated strain on pulmonary parenchyma. Acute associated with increases in whole-lung macrostrain, correlated increased pathology. However, effect alveolar microstrain remains unknown....
Background Previous studies have shown the effect of bacterial lipopolysaccharide (LPS) on enhanced cancer cells’ growth and metastasis. However, LPS prostate (PCa) cells metastasis has not been investigated in details. This study aimed to investigate functional role PCa determine dexamethasone (DEX) this event. Methods Two different reporter lines (DU145‐NF‐κB‐Luc MAT‐LyLu‐ NF‐κB‐Luc) were used assess direct NF‐κB activation cells. Plasma collected from LPS‐stimulated human rodent blood...
Ventilator-induced lung injury may arise from heterogeneous microanatomy, whereby some alveoli remain collapsed throughout the breath cycle while their more compliant or surfactant-replete neighbors become overdistended, and this is called dynamic alveolar heterogeneity.To determine how heterogeneity influenced by 2 modes of mechanical ventilation: low tidal-volume ventilation (LTVV) airway pressure release (APRV), using in vivo microscopy to directly measure size distributions.In a...
Lung injury is often studied without consideration for pathologic changes in the chest wall. In order to reduce incidence of lung using preemptive mechanical ventilation, it important recognize influence altered wall mechanics on disease pathogenesis. this study, we hypothesize that airway pressure release ventilation (APRV) may be able elastance associated with an extrapulmonary model as compared low tidal volume (LVt) ventilation. Female Yorkshire pigs were anesthetized and instrumented....
Acute respiratory distress syndrome causes a heterogeneous lung injury with normal and acutely injured tissue in the same lung. Improperly adjusted mechanical ventilation can exacerbate ARDS causing secondary ventilator-induced (VILI). We hypothesized that peak airway pressure of 40 cmH2O (static strain) alone would not cause additional either or unless combined high tidal volume (dynamic strain). Pigs were anesthetized, acute (ALI) was created by Tween instillation via bronchoscope to both...
BACKGROUND Prostate cancer (PCa) cells express Toll‐like receptor‐4 (TLR4), a known pro‐tumorigenic molecule for different cells. The residing in the avascular region of tumor confront various metabolic stresses and continuously adapt mechanisms to overcome them. We hypothesized that TLR4 activation might provide direct survival advantage metabolically stressed PCa METHODS first investigated effect LPS on serum deprived To understand molecular involved mediated survival, we next change...
The role of microbiota in the pathophysiology benign prostate hyperplasia (BPH), especially creating an inflammatory milieu may not be avoided. major objectives this study were to investigate microbial composition BPH tissues, its association with inflammation and check effect clinically isolated bacteria on epithelial cells.The includes 36 patients a pathological diagnosis BPH. Following strict aseptic measures, tissues collected after transurethral resection prostate, multiple pieces...
The ASA physical classification score has a major impact on the observed/expected (O/E) mortality ratio in NSQIP General Vascular Mortality Model. difference predicted is greatest between ASAs 3 and 4. We hypothesized under-classified scores significantly affect O/E mortality.We conducted retrospective review of essential surgery cases from January 2014 to December (n = 1264) with sub-analysis 33) at our institution. recorded transfer emergency status independently calculated for mortalities...
Maximal thymectomy was carried out in 48 patients with myasthenia gravis (MG). There were 18 males and 30 females. Thymic hyperplasia found 38, atrophic thymus 8, patients. Two had thymoma. In the non-thymomatous complete remission achieved 16 (34.8%) pharmacological 20 (43.5%) thus giving a total 36 (78.3%) Six (13%) improved. no improvement four Thus, overall benefit from 91.4% this series. We that sex, age at onset of disease steroid therapy influenced outcome thymectomy. On other hand,...
// Sujit Suklabaidya 1, 2 , Biswajit Das Syed Azmal Ali 3 Sumeet Jain Sharada Swaminathan 4 Ashok K. Mohanty Susen Panda 5 Pujarini Dash 1 Subhankar Chakraborty 6 Surinder Batra 7 Shantibhusan Senapati Tumor Microenvironment and Animal Models Laboratory, Department of Translational Research, Institute Life Sciences, Bhubaneswar, Odisha, India Manipal University, Manipal, Karnataka, Proteomics Structural Biology Biotechnology Department, National Diary Research Institute, Haryana,...
Staphylococcus aureus is a common cause of nosocomial pneumonia frequently resulting in acute respiratory distress syndrome (ARDS). Surfactant protein B (SP-B) gene expresses two proteins involved lowering surface tension and host defense. Genotyping studies demonstrate significant association between human SP-B genetic variants ARDS. Curcumins have been shown to attenuate inflammation many sepsis models. Our hypothesis that functional differences treatment with curcumin (CMC2.24) modulate...
Mesenchymal stem cells (MSCs) have gained much interest to be used as targeting vehicle in cancer therapy due the intrinsic tumor-homing behavior associated with them. In this scenario, superparamagnetic nanoparticles are emerging an ideal probe for noninvasive cell tracking different applications. study, it is demonstrated that formulated aqueous dispersible glyceryl monooleate coated magnetic (MNPs) can act a better labeling and efficient agent without affecting inherent properties of...
Abstract Disclosure: A.M. Skariah: None. S. Jain: Background: Takotsubo cardiomyopathy (TCM) also know as broken heart syndrome is a transient decrease in systolic cardiac function the absence of obstructive CAD. TCM likely related to hyperadrenergic conditions leading increased sensitivity catecholamine surge cardiomyopathy. more associated with hyperthyroidism. Case presentation: Patient an 84-year-old female PMH celiac disease,hypertension,prediabetes, and atrial fibrillation s/p...
The regionalization of trauma care, the Emergency Medical Treatment and Active Labor Act 1986, advent Accountable Care Organizations bundled payments have brought Level 1 centers (TC) to a new crossroads. By protocol, injured patients are preferentially transferred designated TCs when higher level care is indicated. Trauma transfers frequently come during off hours may not always appear be related injury severity. Based on this observation, we hypothesized from regional hospitals would lower...
Calcineurin inhibitors (cyclosporine and tacrolimus) are important constituents of post renal transplant immunosuppression. However, toxicity limits their utility. Histological features calcineurin inhibitor (CNIT) have been the subject few studies using protocol biopsy samples, consensus on diagnostic criteria is still evolving.To analyze spectrum histological changes in allograft biopsies with evidence CNIT identify additional that likely to help pathologist arriving at a diagnosis.One...