Herein, a nickel-catalyzed synthesis of an aryl nitrile via exchange between aromatic amide and simple was developed. By using cheap, easy-to-handle, low-toxic 4-cyanopyridine as the cyanating source, cyanation various amides afforded assortment nitriles including bioactive drugs organic luminescent molecules in good yields. The reaction exhibited wide substrate scope, functional group tolerance, unique selectivity that were complementary to traditional methods. Moreover, two key nickel...

Transition metal-catalyzed cross-coupling reactions have emerged as one of the most attractive methods in organic synthesis recent years. However, due to inertness C-C bonds, bond activation enabled are far less common. In this work, first example palladium-Transition palladium-catalyzed ynones with aryl bromides for diarylacetylenes via C(O)-C(sp) was described. The reaction exhibited directing group-free unstrained activation, wide substrate scope, and good functional group tolerance....

C-C bond cleavage reactions have achieved remarkable progress in molecular deconstruction and skeleton editing. In this study, we describe a palladium-catalyzed synthesis of diaryl ketones through sequence α-arylation aerobic oxidative cleavage. This transformation features good functional group compatibility, especially for highly reactive groups, including -OH, NH2, -CHO. Furthermore, approach allows gram-scale low catalyst loading manner. It also streamlines the variety drugs or their...

A rhodium-catalyzed transarylation of benzamides via selective C–C bond activation with arylboronic acids was described, which distinct from the conventional metal-catalyzed C–N activation. This transformation exhibited good functional group compatibility yields up to 88%, offering a practical approach for construction and functionalization benzamides. Preliminary experimental computational studies revealed selectivity metal insertion into or greatly affected by substituents on amide's N atom.

Transition-metal-catalyzed C–C bond activation has emerged as an increasingly effective method for reorganizing a molecular skeleton. Ketone, versatile functional molecule, been extensively studied the reaction. However, most of unstrained ketones generally follows oxidative addition strategy, while nucleophilic 1,2-addition carbonyl moiety followed by β-C elimination strategy was less studied. Here palladium-catalyzed ketone enabled removable directing group through to synthesize...

Herein, a palladium-catalyzed 1,3-alkynyl migration of allylic alcohol for the synthesis β-alkynyl ketone was described. This intramolecular rearrangement reaction demonstrated an enhanced reactivity compared to traditional intermolecular alkynylation by circumventing dimerization alkynes, exhibiting specific selectivity toward elimination. Moreover, this featured wide substrate scope, good functional group tolerance, and 100% atom economy.

Herein, the divergent transformations of 1,3-diols with arylhydrazines via acceptorless dehydrogenative coupling reactions to selectively synthesize pyrazoles and 2-pyrazolines were reported, which based on Ru3(CO)12/NHC-phosphine-phosphine catalytic systems. The featured low catalyst loading, high selectivity, wide substrate scope, good yields, only water hydrogen gas (H2) as byproducts.

The first synthesis of <italic>N</italic>-substituted lactams <italic>via</italic> an acceptorless dehydrogenative coupling diols with primary amines in one step was enabled by combining Ru₃(CO)₁₂ a hybrid N-heterocyclic carbene–phosphine–phosphine ligand as the catalyst.

A rhodium-catalyzed Suzuki–Miyaura coupling reaction via C(O)-C bond activation to form 2-benzoylpyridine N-oxide derivatives is reported. Both the C(O)–C(sp2) and C(O)–C(sp3) could be activated during with yields up 92%. The moiety employed as a traceless directing group, leading free pyridine ketones.

A chelation-assisted palladium-catalyzed C═C bond cleavage of α, β-unsaturated ketone to form alkenyl nitrile in the presence is disclosed on basis a formal group-exchange reaction formulated as C1═C2 + C3 → C1═C3 C2, differing from normal alkene oxidative and metathesis type. The isolated key active Pd(II) complex well deuterium-labeled experiment revealed necessity chelation group, plausible catalytic pathway was proposed.

Herein, an aerobic reconstruction of amines to amides via C(sp

A simple protocol of iron(III)-catalyzed halogenation 8-amidoquinolines in water under mild conditions was developed, affording the 5-halogenlated products good to excellent yields up 98%. The reaction mechanism most likely involves a single-electron transfer (SET) process.

An Fe-catalyzed coupling reaction between oxime ester and benzothiazole is described, which involves C-C bond cleavage of via a single-electron transfer process. This iron catalytic system performed in water under mild conditions offers streamlined strategy to the construction alkyl nitrile substituted derivatives. Application this for synthesis some key important compounds including 4-heterocyclic-3-arylbutanoic acid also reported.

C-H bond functionalization is one of the hot spots in research field organic chemistry, and selective activation a challenging project.Among these reactions, solvent normally used as reaction media.Using cheap, environmentally friendly water would be line with requirements "green chemistry" low-carbon sustainable development.This paper reviews recent progress aqueous catalyzed including hybridized sp-, sp 2 -, 3 -C-H bonds.

An Fe( iii )-catalysed transformation of secondary N -phenyl substituted amides to primary by an electrochemical method is developed.

N-phenylmaleimide (N-PMI) and its precursor, (Z)-4-oxo-4-(phenylamino)but-2-enoic acid, were synthesized from aniline maleic anhydride. Copolymerization between styrene was initiated in micropores outside surface of porous polyvinyl chloride (PVC) resin suspended aqueous phase. The modified PVC characterized with Gel Permeation Chromatography, thermal gravimetric analysis scanning electron microscopy. result high performance liquid chromatography shows that the purity N-PMI reached 97.3%....

Herein, a nickel-catalyzed aryl exchange reaction for the synthesis of sulfides from aromatic amides and thioethers was reported. This work not only realized activation non-activated primary through an unconventional dehydration strategy, but also provided practical facile method sulfide without odorous toxic thiols.