A5001862600- Multiple Sclerosis Research Studies
- Skin and Cellular Biology Research
- Peripheral Neuropathies and Disorders
- Kruppel-like factors research
- Systemic Lupus Erythematosus Research
- Systemic Sclerosis and Related Diseases
- Vestibular and auditory disorders
- Optical Coherence Tomography Applications
- Neurological and metabolic disorders
- Sleep and Wakefulness Research
- Alcoholism and Thiamine Deficiency
- Rheumatoid Arthritis Research and Therapies
- Vitamin C and Antioxidants Research
- CNS Lymphoma Diagnosis and Treatment
- Ultrasound Imaging and Elastography
- Autoimmune and Inflammatory Disorders Research
- Amyotrophic Lateral Sclerosis Research
- Spinal Fractures and Fixation Techniques
- Bone and Joint Diseases
- Pelvic and Acetabular Injuries
Univerzitná Nemocnica Louisa Pasteura
2015-2023
University of Pavol Jozef Šafárik
2021-2023
Introduction: There is a need for blood biomarkers of disease activity in multiple sclerosis (MS). The aim the study was to assess relationship between plasma neurofilament light chain (pNfL) and as defined by concept three-domain no evident (NEDA-3). Methods: Levels pNfL (SIMOA) were examined 159 MS patients analyzed NEDA-3 status (absence relapse, disability score worsening, brain magnetic resonance activity) during last 12 months. accuracy proposed model evaluated calculating area under...
Background: The research is focused on sensitive biomarkers in multiple sclerosis (MS). Objective: aim of the study was to assess relationship between plasma neurofilament light chain (pNfL) and disease activity as defined by concept NEDA (no evident activity), including brain volumetry, a cohort MS patients treated with disease-modifying treatment (DMT). Methods: Levels pNfL (Single Molecule Array (SIMOA) technology) were examined 95 RRMS (relapsing-remitting sclerosis) analyzed NEDA-3...
Multiple sclerosis (MS) is a chronic disorder with variable course. The aim of our study was to find out whether cognitive event-related potentials are prognostic for patient disability at the 15-year follow-up.In observed cohort patients MS, we examined baseline (2003). Functional status (Expanded Disability Status Scale score) then assessed 15 years later, and model developed using binary logistic regression analysis. independent variables included demographic (age, sex, education),...
: Neuromyelitis optica spectrum disorders (NMOSDs) are a group of rare, inflammatory, demyelinating diseases that affect the central nervous system. Neither incidence nor prevalence NMOSD has been determined in Slovakia thus far. The aim this study was to determine both and using 2015 International Panel diagnosis (IPND) criteria.: We performed population-based estimate during period from 1 January 2006 through 31 December 2019. cases were reported multiple sources subsequently verified IPND...
Background and Objectives: Neurofilament light chain (NfL) is a sensitive biomarker of neuroaxonal damage. This study aimed to assess the relationship between annual change in plasma NfL (pNfL) disease activity past year, as defined by concept no evidence (NEDA) cohort multiple sclerosis (MS) patients. Materials Methods: Levels pNfL (SIMOA) were examined 141 MS patients analyzed NEDA-3 status (absence relapse, disability worsening, MRI activity) NEDA-4 (NEDA-3 extended brain volume loss ≤...
Neurofilament light chain is a promising biomarker of disease activity and treatment response in relapsing-remitting multiple sclerosis (MS). Its role progressive MS less clear.The aim the study was to assess relationship between plasma neurofilament (pNfL) as defined by concept NEDA-3 (No Evident Disease Activity), brain volumetry, cohort patients with form (PMS).Levels pNfL (SIMOA technology) were examined 52 PMS analysed status annual volume loss (BVL) during last 12 months. The...
Individuals with alcohol use disorder frequently suffer from vitamin D deficiency, in addition to deficiencies vitamins B12, folic acid and B1. This is due inadequate dietary intake behavioural changes. Each of these results different clinical symptoms. Subacute spinal cord degeneration, together radicular sensorimotor peripheral neuropathy, arises B12 deficiencies. B1 deficiency leads Wernicke's encephalopathy, which can include the classical triad symptoms (i.e. cognitive changes, ataxia...
Sclerosis multiplex (SM) je autoimunitné ochorenie centrálneho nervového systému.V súčasnosti máme k dispozícii pomerne širokú škálu modifikujúcich liečiv (Disease Modifying Therapy -DMT) s rôznym mechanizmom účinku a účinnosťou.Na dosiahnutie čo najlepšieho liečebného ovplyvnenia ochorenia potrebný individuálny prístup pri výbere liečby.Je potrebné mať na pamäti aj riziká zvolenej liečby pre daného pacienta
Vertebral haemangioma is a benign vascular tumour mostly seen in the thoracic region of spine. Spinal haemangiomas are usually asymptomatic and discovered incidentally. In few patients, however, aggressive vertebral can cause local pain, radicular pain or neurologic deficits, which result from neural compression. The aetiology origin unclear probably multifactorial. Hormonal biological changes pregnant women lead to accelerated growth haemangioma. our report, we present case patient who was...
Cieľom účinnej liečby sclerosis multiplex najnovšími preparátmi je zabrániť progredujúcej disabilite pacienta.Nenaplnenou potrebou pre dennú prax absencia validných laboratórnych biomarkerov, ktoré by nám okrem zobrazovacích metód, ako sú magnetická rezonancia mozgu a miechy, ukázali práve prebiehajúcu aktivitu ochorenia u jednotlivého pacienta efekt podávanej liečby.Neurofilamenty ľahkých reťazcov (NfL) sa považujú za nešpecifický biomarker neurodegenerácie dajú ľahko vyšetriť z krvi.V...