Curcumin, a constituent of the turmeric plant, has antitumor, anti‐inflammatory, and antioxidative effects, but its effects on wound healing are unclear. We created back wounds in 72 mice treated them with or without topical curcumin (0.2 mg/mL) Pluronic F127 gel (20%) daily for 3, 5, 7, 9, 12 days. Healing was evaluated from gross appearance, microscopically by haematoxylin eosin staining, immunohistochemistry tumour necrosis factor alpha smooth muscle actin, polymerase chain reaction...

Background Osteoradionecrosis (ORN) of the mandible is not an uncommon complication after radiotherapy for head and neck cancers. Although definitive treatment has been confirmed as radical excision necrotic bone with simultaneous vascularized osteocutaneous flap reconstruction, it remains a unique challenge. In this study, we compare our results reconstruction free iliac fibula flaps in survival, bony union, postoperative complications. Patients Methods From 1986 to 2011, there were 153...

Background We have previously described a modified chimeric fibular osteocutaneous flap design based on combination of traditional and peroneal artery perforator fasciocutaneous for mandible adjacent soft tissue reconstruction. The purpose this article is to share our experience with larger case series utilizing new technique reconstruction after cancer wide excision surgery more detailed description these flaps harvesting procedures. Patients methods Ten patients (age range from 32 63...

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To understand the pathology and molecular signatures of microangiopathy in diabetic neuropathy, we systemically quantitatively examined morphometry microvascular nerve pathologies sural nerves. In endoneurium nerves, prominent evidenced by reduced capillary luminal area, increased basement membrane thickness, proportion fibrin(+) blood vessels. Furthermore, thickness vessels were correlated with small myelinated fiber density there was significant macrophage T cell infiltration, cluster...

The most common postoperative complication after reconstructive surgery is flap necrosis. Adipose-derived stem cells (ADSCs) and their secretomes are reported to mediate skin repair. This study was designed investigate whether conditioned media from ADSCs (ADSC-CM) protects ischemia/reperfusion- (I/R-) induced injury in flaps by promoting cell proliferation increasing the number of hair follicles. mouse model ischemia ligating long thoracic vessels for 3 h, followed blood reperfusion....

Abstract Delivering gene constructs into the dorsal root ganglia (DRG) is a powerful but challenging therapeutic strategy for sensory disorders affecting DRG and their peripheral processes. The current delivery methods of direct intra-DRG injection intrathecal have several disadvantages, including potential injury to neurons low transfection efficiency, respectively. This study aimed develop spinal nerve deliver polyethylenimine mixed with plasmid (PEI/DNA polyplexes) containing green...

ABSTRACT Gordonia amicalis infection has never been reported in humans. We report here the first case of G. -related cutaneous after a traumatic injury. The isolate was confirmed by 16S rRNA sequencing analysis, and patient responded well to repeated debridement antibiotic treatment.

Background: Reinnervation of target tissues determines functional outcomes after nerve grafting, which is important in traumatic injury caused by accidents or consequences resulting from surgical removal tumors. Previous studies documented the influences repair mainly based on morphometry but rarely compared final according to reinnervation patterns fibers different categories. Methods: In a mouse model authors analyzed innervation indexes transection-reimplantation sciatic nerve, were...

Ischemia is an important etiology of painful neuropathies. We generated a mouse system ischemic neuropathy by ligation‐reperfusion the femoral artery to mimic neuropathic pain and nerve injury patterns observed clinically. Mice exhibited spontaneous behaviors, which were most obvious after ischemia for 5 h. Mechanical cold allodynia developed post‐operative day (POD) 7 persisted through experimental period up POD 56. Neuropathic behaviors alleviated with intraperitoneal gabapentin (50 100...

Quality of life and functional improvement have emerged as important goals for patients with oncologic disease. For head neck cancer, free anterolateral thigh (ALT) flaps serve reliable reconstruction provide restoration. Nevertheless, factors affecting the resumption oral feeding are rarely described. This study aimed to evaluate compare outcomes different defect patterns reconstructive ALT flap designs.We retrospectively reviewed cancer undergoing ablation between January 2016 April 2018...

The free fibular osteocutaneous flap is a commonly used for mandible and buccal mucosa reconstruction in head neck cancer surgery. However, the skin paddle restriction from intermuscular septum often limits soft tissue reconstruction.We have proposed new modified chimeric design based on combination of traditional peroneal artery perforator fasciocutaneous to overcome septum.We successfully applied this 2 patients after wide excision surgery.The can be easily segmental defect over adjacent...

Scalp angiosarcomas (AS) are aggressive soft tissue sarcomas that present with outcomes different from other AS of the head and neck region. Due to rarity disease, limited data on clinical outcome scalp available. In particular, prognostic significance surgical margins remains controversial impact margin status survival has not been documented. We retrospectively reviewed 41 patients, including 30 patients localized disease 11 initial distant metastasis, treated in our institution between...

Abstract Objective Despite amyloid deposition as a hallmark of hereditary transthyretin amyloidosis (ATTRv) with polyneuropathy, this pathology could not completely account for nerve degeneration. ATTRv patients frequently have vasomotor symptoms, but microangiopathy hypothesis in was systemically clarified. Methods This study examined the vascular sural nerves (TTR) mutation p.Ala117Ser (TTR‐A97S), focusing on morphometry and patterns molecular expression relation to We further applied...

Hsieh, Jung-Hsien MD; Wu, Yi-Chia Chen, Hung-Chi Yueh-Bih Tang MD, PhD Author Information

Introduction Reconstruction of a full-thickness defect that includes oral commissure presents considerable challenge to maxillofacial and plastic surgeons. The goals reconstruction are both functional cosmetic. Sialorrhea, or drooling, is major problem after flap influences the quality life patient. In this article, we report on our experience performing dermal sling operation treat postoperative sialorrhea in patients with cancer. Materials Methods Preoperative levels were evaluated based...

Objective Although the microenvironment for peripheral nerve regeneration is permissive, such a mechanism defective in diabetes, and molecular mediators remain elusive. [Correction added on May 11, 2022, after first online publication: In preceding sentence, “is ok” was changed to defective”.] This study aimed (1) investigate relationship between skin innervation collagen pathology diabetic neuropathy (2) clarify alterations that occur response hyperglycemia their effects axon regeneration....

For locally advanced head and neck cancers, intra-arterial (IA) chemotherapy is utilized for locoregional control with favorable results. The study aimed to evaluate the surgical outcomes of microsurgical reconstruction in cancer patients IA This cohort retrospectively reviewed who underwent from January 2014 August 2018. Patients prior history were included categorized into two groups according (IA group)/intravenous (IV group). Flap survival was evaluated along revision rates...

Background: In Taiwan, cancer is the leading cause of death, and oral accounts for 6th death. Most patients are male. However, female have different demographic background (such as betelnut, alcohol, cigarette use) from males, few studies focused on disease character, reconstructive methods, prognosis patients. Aims Objectives: This study designed to identify gender difference cancer, including presentation, subsequent modalities, survival analysis. Materials Methods: From 2002 2007, 21 318...