A5101626889- Genetic Syndromes and Imprinting
- Genetics and Neurodevelopmental Disorders
- Diabetes Management and Research
- Fetal and Pediatric Neurological Disorders
- Neurological and metabolic disorders
- Diet, Metabolism, and Disease
- Epilepsy research and treatment
- Diabetes and associated disorders
- Impact of Light on Environment and Health
- Diabetes Management and Education
- Metabolism and Genetic Disorders
- Diet and metabolism studies
- Blood Coagulation and Thrombosis Mechanisms
- Cerebrospinal fluid and hydrocephalus
- Neurogenetic and Muscular Disorders Research
- Renal Transplantation Outcomes and Treatments
- Renal Diseases and Glomerulopathies
- Diabetes Treatment and Management
- Cardiac Valve Diseases and Treatments
- Cancer, Hypoxia, and Metabolism
- Ion Transport and Channel Regulation
- Viral-associated cancers and disorders
- Epigenetics and DNA Methylation
- Neurological Disorders and Treatments
- Chronic Kidney Disease and Diabetes
Mie Chuo Medical Center
2023
National Hospital Organization
2023
Niigata University
2011-2021
University of California, Davis
2017
Sendai Tateyama Tanaka School
2013-2016
Massachusetts General Hospital
2012
Harvard University
2012
National Center of Neurology and Psychiatry
2008
Allen Institute for Brain Science
2006
Shibaura Institute of Technology
2002
The aim of the present study was to investigate prevalence fear hypoglycemia, in association with severe hypoglycemia and social factors, insulin-treated patients type 2 diabetes mellitus. A questionnaire survey on patient-physician communication carried out 355 mellitus at 16 hospitals clinics. reported by 27.7% patients. stepwise logistic regression analysis found that during past 1 year a significant determinant (odds ratio 2.16, 95% confidence interval 1.06-4.41; P = 0.034), age 1.02,...
OBJECTIVE. The purpose of this work was to detect brain developmental abnormalities in Prader-Willi syndrome by using diffusion tensor imaging based on a high-field MRI system. METHODS. Eight patients with and 8 age- gender-matched normal control subjects were examined (3.0 T) Trace value fractional anisotropy assessed simultaneously multiple representative regions: the deep gray matter (putamen, caudate head, dorsomedial thalamus) white structures (frontal parietal matter, posterior limb...
Aquaporin 4 (AQP4), the most abundant isozyme of water specific membrane transporter aquaporin family, has now been implicated to play a significant role in pathogenesis various disease processes nervous system from epilepsy Alzheimer's disease. Considering its clinical relevance, it is highly desirable develop noninvasive method for quantitative analysis AQP distribution humans under settings. Currently, choice such diagnostic examinations continues be positron emission tomography (PET)....
Objective To investigate whether water influx into cerebrospinal fluid (CSF) space is reduced in Alzheimer's patients as previously shown the transgenic mouse model for disease. Methods Ten normal young volunteers (young control, 21-30 years old), ten senior (senior 60-78 old, MMSE ≥ 29), and disease (AD) (study group, 59-84 MMSE: 13-19) participated this study. All AD were diagnosed by neurologists specializing dementia based on DSM-IV criteria. CSF dynamics analyzed using positron emission...
HS-142-1, a novel polysaccharide, isolated from the culture broth of Aureobasidium pullulans var. melanigenum, has been found to inhibit selectively binding [125I]atrial natriuretic peptide (ANP) guanylyl cyclase-linked ANP receptor (ANP-B receptor) and production cyclic GMP by ANP. The effect this compound on renal vascular actions evoked exogenously administered peptides was examined in anesthetized rats. increase urine flow urinary excretion sodium elicited human or porcine brain...
HS-142-1, a specific nonpeptide antagonist for the atrial natriuretic peptide (ANP) receptor, equally blocked rat ANP (rANP)-, porcine brain peptide-, or C-type peptide-stimulated GMP production in cultured bovine aortic smooth muscle (BASM) and endothelial (BAE) cells concentration-dependent fashion, at concentrations of 1-300 micrograms/ml. But, even 300 micrograms/ml, HS-142-1 only weakly inhibited binding 125I-rANP to BASM BAE cells, where small portion sites are linked guanylyl cyclase....
Objectives: Video-assisted thoracoscopic surgery (VATS) is generally recognized as a less invasive method than thoracotomy. However, the influence of VATS on postoperative pulmonary gas exchange has yet to be evaluated. Methods: Thirty eight patients with spontaneous pneumothorax were randomized into bullectomy by (n = 20) or axillary thoracotomy 18). Gas was assessed using hot wire mass spectrometer, and blood analysis preoperatively postoperatively at 1, 3, 6, 12, 24, 48 h days 4 6. Post...
Glucagon is recommended to treat severe hypoglycemia in nonhospital environments, when a patient with type 1 diabetes mellitus (T1DM) unconscious and unable eat or drink. However, the actual possession rate of glucagon Japan has not been investigated.We recruited 208 T1DM patients older than 15 years age. The were treated at 16 hospitals clinics different regions Japan. Answers obtained using self-administered questionnaire about possession, experience usage, preference possess after reading...
Abstract The objective of this study was to investigate lobule-specific cerebellar structural alterations relevant clinical behavioral characteristics Prader-Willi syndrome (PWS). We performed a case-control 21 Japanese individuals with PWS (age; median 21.0, range 13–50 years, 14 males, 7 females) and 40 age- sex-matched healthy controls typical development. Participants underwent 3-Tesla magnetic resonance imaging. Three-dimensional T 1 -weighted images were assessed for lobular volume...
BackgroundSimulation using a mock scanner preparation is beneficial for pediatric patients undergoing magnetic resonance imaging (MRI) without sedation the assessment of neurocognitive function. However, simulation protocol improving completion MRI has not been studied extensively.MethodsA "Zero-Tesla" immediately before 3T was utilized based on participants' demographics. The success rate each step compared between children with typical development (TD) and those neurodevelopmental...
To perform a systematic analysis of the intrinsic contrast parameters FLAIR hyperintense rim (FHR), thin layer high intensity covering entire surface cerebral cortex detected on fluid-attenuated inversion recovery (FLAIR) sequence T2 weighted imaging performed 7T system, in an attempt to identify its anatomical correlate.Fast spin echo (FSE-IR) and cardiac-gated fast (FSE) images were obtained with defined eight normal volunteers 7 T MRI system determine proton density, T1 characteristics....
Insulin degludec/insulin aspart (IDegAsp) is a soluble combination of insulin degludec (70%) and (30%). The present exploratory trial investigated the safety switching unit-to-unit from twice-daily basal or pre-mix to IDegAsp in Japanese patients with type 2 diabetes.In this 6-week, open-label, parallel-group, controlled trial, 66 participants were randomized (1:1) receive either biphasic 30 (BIAsp 30) twice daily at same total dose as pre-trial insulin. During doses adjusted according...
Individuals with Prader-Willi syndrome (PWS) exhibit complex behavioral characteristics, including hyperphagia, autistic features, and subsequent age-related maladaptive behaviors. While this suggests functional involvements of subcortical, limbic, brainstem areas, developmental abnormalities in such structures remain to be investigated systematically. Twenty-one Japanese individuals PWS 32 healthy controls typical development were included. T1-weighted three-dimensional structural magnetic...
Aquaporin (AQP) water channels play a significant role in mesenchymal microvascular proliferation and infiltrative growth. AQPs are highly expressed malignant astrocytomas, positive correlation is observed between their expression levels histological tumor grade.To examine the utility of aquaporin positron emission tomography (PET) for differentiating astrocytoma grade III IV using AQP radioligand [11C]TGN-020.Fifteen patients, (n = 7) 8), 10 healthy volunteers underwent [11C]TGN-020 PET...
Objective: This study aimed to investigate brain developmental alterations in individuals exposed childhood maltreatment (CM) with dissociative experiences and motor coordination symptoms using diffusion tensor imaging on a 3Tesla (3T) magnetic resonance (MR) system.Methods: Five CM who manifest behavioral problems (age range: 14–18 years; all female), as well seven age- gender-matched normal control individuals, participated the 3T MR system. Diffusion characteristics, indexed by fractional...
Prader-Willi syndrome is a complex endocrinological and developmental disorder characterized by hyperphagic, autistic, obsessive behaviors, which have been considered to primarily originate from hypothalamus-pituitary axis system alterations in the brain. While pituitary gland has demonstrated contribute behavioral phenotypes associated with neuropeptide, e.g., arginine-vasopressin, relevant remain unknown. This study aimed investigate abnormalities structures determine whether structural...
Background: Prader-Willi syndrome (PWS) is a genetic with clinical behavioral phenotypes, including autistic characteristics. However, brain functional connectivity (Fc) remains underreported. This study aimed at investigating alterations in network architecture the cortical and subcortical structures of brains individuals PWS. Methods: Twelve PWS (age range: 15-42 years; female 4, male 8), 14 age- sex-matched controls typical development (TD), participated 3 Tesla resting-state magnetic...
<p dir="ltr">The early pathogenetic mechanism of diabetic retinopathy (DR) and its treatment remain unclear. Therefore, we <a href="" target="_blank">investigated the pathogenic alterations in DR using streptozotocin-induced mice protective effect sodium-glucose cotransporter 2 (SGLT2) inhibitors against these alterations</a>. Retinal vascular leakage was assessed by dextran fluorescence angiography. thickness were increased 4 weeks after onset diabetes, respectively....