A5088453834- Laser Applications in Dentistry and Medicine
- Nanoplatforms for cancer theranostics
- SARS-CoV-2 and COVID-19 Research
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- COVID-19 Clinical Research Studies
- Circadian rhythm and melatonin
- Cell death mechanisms and regulation
- Muscle Physiology and Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Calcium signaling and nucleotide metabolism
- Photodynamic Therapy Research Studies
- Hair Growth and Disorders
- Autophagy in Disease and Therapy
- Exercise and Physiological Responses
- Wound Healing and Treatments
- Bee Products Chemical Analysis
- Immune cells in cancer
- Free Radicals and Antioxidants
- Dermatologic Treatments and Research
- Cancer-related Molecular Pathways
- Advanced Glycation End Products research
- Hydrogen's biological and therapeutic effects
- PARP inhibition in cancer therapy
- Medical Imaging Techniques and Applications
South China Normal University
2016-2025
Sun Yat-sen University
2017
Chemoresistance is a major obstacle to effective breast cancer chemotherapy. However, the underlying molecular mechanisms remain unclear. In this study, nuclear receptor coactivator 3 (NCOA3) was found be significantly increased in taxol-resistant tissues and cells. Moreover, overexpression of NCOA3 enhanced cell resistance taxol, whereas depletion decreased taxol resistance. Subsequently, we investigated whether expression regulated by miRNAs cancer. By bioinformatics prediction combination...
Photobiomodulation therapy (PBMT) has shown encouraging results in the treatment of hair loss. However, mechanism by which PBMT controls cell behavior to coordinate cycle is unclear. Here, found drive quiescent follicle stem (HFSC) activation and alleviate atrophy. Mechanistically, triggers a new upregulating β-CATENIN expression HFSCs. Loss β-Catenin (Ctnnb1) HFSCs blocked PBMT-induced regeneration. Additionally, we show reactive oxygen species (ROS) activate PI3K/AKT/GSK-3β signaling...
Radiation-induced brain injury (RIBI) is the most serious complication of radiotherapy in patients with head and neck tumors, which seriously affects quality life. Currently, there no effective treatment for RIBI, identifying new that targets pathological mechanisms RIBI urgently needed.Immunofluorescence staining, western blotting, quantitative real-time polymerase chain reaction (Q-PCR), co-culture primary neurons microglia, terminal deoxynucleotidyl transferase dUTP nick-end labeling...
The immune system has been implicated in synaptic plasticity, inflammation, and the progression of Alzheimer's disease (AD). However, there were few studies on improving niche microenvironment neural stem cells (NSCs) brain AD to promote adult hippocampal neurogenesis (AHN) by regulating function non-parenchymal cells.The lymph nodes amyloid precursor protein/presenilin 1 (APP/PS1) 3xTg (APP/PS1/tau) mouse models treated with photobiomodulation therapy (PBMT) for 10 J/cm2 per day month (10...
Abstract Immunotherapy has shown tremendous promise for improving cancer treatment. Unfortunately, antigen‐presenting cells (APCs) in patients cannot effectively recognize and process tumor antigens to activate host immune responses. In this study, an approach is developed improve immunotherapy that utilizes endogenous antigen‐carrying nanoparticles (EAC‐NPs), which encompasses a set of isolated from solid tumors adjuvants. The EAC‐NPs specifically target APCs subsequently result enhanced T...
Abstract Triple-negative breast cancer (TNBC) shows a higher malignant and poorer clinical outcome compared with other subtypes. Albeit that chemotherapy is the first choice for TNBC treatment, rapid emergence of chemoresistance variability chemotherapeutic responses in patients call novel therapeutic strategies. Here, we reported evidences highlighting combination BH3 mimetics mTOR inhibitors could be promising strategy to improve treatment. Our results showed mimetic ABT263 typical...
Abstract Gene editing of living cells has become a crucial tool in medical research, enabling scientists to address fundamental biological questions and develop novel strategies for disease treatment. This technology particularly revolutionized adoptive transfer cell therapy products, leading significant advancements tumor treatment offering promising outcomes managing transplant rejection, autoimmune disorders, inflammatory diseases. While recent clinical trials have demonstrated the safety...
Abstract Atherosclerosis is a chronic inflammatory disease related to massive accumulation of cholesterol in the artery wall. Photobiomodulation therapy (PBMT) has been reported possess cardioprotective effects but no consensus on underlying mechanisms. Here, we aimed investigate whether PBMT could ameliorate atherosclerosis and explore potential molecular The Apolipoprotein E ( ApoE ) −/− mice were fed with western diet (WD) for 18 weeks treated once day last 10 weeks. Quantification based...
Hair follicle stem cells (HFSCs) are recognized as multipotential with exceptional proliferative capacity. Their regulatory effect on skin homeostasis is orchestrated through intricate signaling pathways, including Wnt/β-catenin, transforming growth factor-β/bone morphogenetic protein (TGFβ/BMP), Notch, and Hedgehog. Concurrently, HFSCs inhabit the bulge region of outer root sheath hair (HF), serving epicenter for skin-organizing during homeostasis, engaging in dynamic interactions other...
Abstract Cancer cachexia-associated muscle wasting as a multifactorial syndrome, is an important factor affecting the long-term survival rate of tumor patients. Photobiomodulation therapy (PBMT) has emerged promising tool to cure and prevent many diseases. However, effect PBMT on skeletal atrophy during cancer progression not been fully demonstrated yet. Here, we found alleviated myotube diameter induced by cells in vitro , prevented cancer-associated mice bearing tumor. Mechanistically,...
For practical use and cost-effectiveness, the authors have developed a PC-based virtual simulation method with custom-made DRR image many new functions. The shows compatible reliability effectiveness compared commercial versions using workstation in terms of quality, ease use, handling various tools results all crucial parameters such as beam localization target critical organs.