A5035822657- Bacterial biofilms and quorum sensing
- Infections and bacterial resistance
- Microbial Fuel Cells and Bioremediation
- Bacteriophages and microbial interactions
- Marine Sponges and Natural Products
- Bacterial Genetics and Biotechnology
- Membrane Separation Technologies
- Antimicrobial Peptides and Activities
- Antimicrobial agents and applications
- Antibiotic Resistance in Bacteria
- Studies on Chitinases and Chitosanases
Universitat Autònoma de Barcelona
2022-2025
Stenotrophomonas maltophilia are opportunistic, multi-drug-resistant Gram-negative pathogens increasingly prevalent in clinical settings. Quorum sensing (QS) systems play a crucial role their pathogenesis, coordinating bacterial populations and enabling interactions within polymicrobial communities. While not the primary QS mechanism S. maltophilia, these bacteria can respond to acyl-homoserine lactone (AHL)-type autoinducers. Some isolates exhibit AHL-quorum quenching activity, though...
Staphylococcus aureus is a major cause of severe infections including infective endocarditis, but lineage-specific virulence determinants remain unclear. We analyzed 77 S. bacteremic isolates from lineages using phenotypic assays, infection models, and transcriptomics. Our results revealed significant heterogeneity in pathogenicity. ST398 exhibited heightened virulence, characterized by increased hemolysin production, whereas CC30 strains showed reduced growth, biofilm formation,...
Diseases caused by biofilm-forming pathogens are becoming increasingly prevalent and represent a major threat to human health. This trend has prompted search for novel inhibitors of microbial biofilms which could, example, be used potentiate existing antibiotics. Naturally-occurring, halogenated furanones isolated from marine algae have proven effective biofilm in several bacterial species. In this work, we report the synthesis library their subsequent evaluation as opportunistic including...
Abstract Dual species interactions in co-isolated pairs of Staphylococcus aureus and Pseudomonas aeruginosa from patients with tracheobronchitis or bronchial colonization were examined. The genetic phenotypic diversity between the isolates was high making detected strain-specific. Despite this, clinical origin strains, some common pairs. For most pairs, P. exoproducts affected biofilm formation reduced growth vitro its S. counterpart. Conversely, did not impair stimulated swarming motility ....
Stenotrophomonas maltophilia are ubiquitous Gram-negative bacteria found in both natural and clinical environments. It is a remarkably adaptable species capable of thriving various environments, thanks to the plasticity its genome diverse array genes that encode wide range functions. Among these functions, one notable trait remarkable ability resist antimicrobial agents, primarily through mechanisms regulate diffusion across cell membranes. We have investigated Mla ABC transport system S. ,...
Stenotrophomonas maltophilia is an environmental bacterium as well emerging opportunistic multidrug-resistant pathogen. They use the endogenous diffusible signal factor (DSF) quorum sensing (QS) system to coordinate population behavior and regulate virulence processes but can also respond exogenous N-acyl-homoserine lactone (AHL) signals produced by neighboring bacteria. The effect of these QS on global gene expression this species remains, however, unknown. Whole-transcriptome sequencing...
The diffusible signal factor family (DSF) of molecules play an important role in regulating intercellular communication, or quorum sensing, several disease-causing bacteria. These messenger molecules, which are comprised cis-unsaturated fatty acids, involved the regulation biofilm formation, antibiotic tolerance, virulence and control bacterial resistance. We have previously demonstrated how olefinic N-acyl sulfonamide bioisosteric analogues can reduce formation enhance sensitivity a number...
ABSTRACT Stenotrophomonas maltophilia is an environmental bacterium and it also emerging opportunistic multidrug-resistant pathogen. It uses the endogenous DSF quorum sensing (QS) system to coordinate population behaviors regulate virulence processes but can respond exogenous AHL signals produced by neighboring bacteria. Whole-transcriptome sequencing analyses were performed for S. K279a in exponential stationary phases as well cultures after treatment with or AHLs. The results revealed that...