Rhodium-catalysed enantioselective hydroboration of olefins is a valuable synthetic transformation, typically employing chiral catalyst and an achiral borane source. The pertinent chemo-, regio- enantioselectivity issues this reaction are discussed. However, the main emphasis review on evolution catalytic asymmetric hydroboration. This has primarily relied upon development application bidentate P,P P,N ligands which have exhibited varying degrees success in transformation.

Unresolved inflammation underlies the development of fibrosis and organ failure. Here, we investigate potential proresolving eicosanoid lipoxinA4 (LXA4) its synthetic analog benzo-LXA4 to prophylactically modulate fibrotic inflammatory responses in a model early renal fibrosis, unilateral ureteric obstruction (UUO). Male Wistar rats (Animalia, Chordata, Rattus norvegicus) were injected intravenously with vehicle (0.1% ethanol), LXA4 (45 μg/250-g rat), or (15 rat) 15 min prior surgery...

Many natural products and biologically active compounds contain the dihydrofuran subunit. Molecules incorporating either 2-substituted, 2,2-disubstituted 2,3- or 2,5-dihydrofurans are widespread in literature represent key "molecular building blocks". The preparation of substituted dihydrofurans remains a current challenge organic synthesis this microreview details various routes employed for their to end 2004. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)

Abstract Phosphorothioates, phosphonothioates, phosphinothioates and phosphonodithioates are organophosphorus compounds with widespread application, especially in the fields of agrochemicals, medicinal chemistry materials chemistry. Herein, we review modern methods for construction phosphorus‐sulfur bonds these important functional groups. This is organised on basis different synthetic approaches, advantages disadvantages each also examined. magnified image

Lipoxins are a group of biologically active eicosanoids typically formed by transcellular lipoxygenase activity. Lipoxin A4 (LXA4) and B4 (LXB4) biosynthesis has been detected in variety inflammatory conditions. The native lipoxins LXA4 LXB4 demonstrate potent antiinflammatory proresolution bioactions. However, their therapeutic potential is compromised rapid metabolic inactivation PG dehydrogenase-mediated oxidation reduction. Here we report on the stereoselective synthesis aromatic...

This review summarises the many developments in synthesis of acyclic peroxides, with a particular focus on past 20 years, and seeks to update organic chemists about these new approaches.

Pseudomonas aeruginosa, a significant opportunistic pathogen, can participate in inter-species communication through signaling by cis-2-unsaturated fatty acids of the diffusible signal factor (DSF) family. Sensing these signals leads to altered biofilm formation and increased tolerance various antibiotics, requires histidine kinase PA1396. Here, we show that membrane-associated sensory input domain PA1396 has five transmembrane helices, two which are required for DSF sensing. binding is...

Dispersions in n-alkanes of silica particles coated with grafted-C18 chains (silica-g-stearyl) exhibit both upper (UFT) and lower (LFT) flocculation temperatures. The dependence the UFT LFT on particle volume fraction (ϕ), diameter (d) nature alkane (pentane to heptane) has been studied. equilibrium phase diagram (T against ϕ) constructed for one system. Comparison ϕ curve suggests that latter is spinodal curve. A preliminary theory given low-concentration behaviour these systems.

Diseases caused by biofilm-forming pathogens are becoming increasingly prevalent and represent a major threat to human health. This trend has prompted search for novel inhibitors of microbial biofilms which could, example, be used potentiate existing antibiotics. Naturally-occurring, halogenated furanones isolated from marine algae have proven effective biofilm in several bacterial species. In this work, we report the synthesis library their subsequent evaluation as opportunistic including...

In model studies towards the synthesis of harringtonolide, construction tropone moiety via arene cyclopropanation was investigated. The installation lactone ring accomplished by way a Diels-Alder cycloaddition various indenones and a-pyones. incorporation key bridge methyl group subsequent control its stereochemistry is also outlined.

Abstract A robust methodology for the synthesis of phosphorothioates, phosphinothioates and phosphonothioates, including those bearing low molecular weight S ‐alkyl side‐chains, is presented. Application “caesium effect” in conjunction with disulfide 3,3’‐dithiobis(propionitrile), which acts as a shelf‐stable sulfur source, avoids recourse to malodorous alkanethiols toxic P−Cl precursors. diverse range sulfur‐containing organophosphorus targets, phosphorus‐based heterocycles, may be prepared...

We report the good to high-yielding three-step synthesis of non-symmetrical bis(oxazoline)-containing ligands possessing an N-thienylaniline unit. The convergent employed a palladium-catalysed aryl amination 2-(2'-bromothiophene)nitrile as key step, with sixteen prepared in total. These were subsequently applied chromium-catalysed enantioselective Nozaki-Hiyama-Kishi allylation benzaldehyde optimal enantioselectivity 73%.

This review highlights the application of gallium metal and halides as reagents in organic synthesis. Owing to their unique catalytic properties, trihalides are considered effective Lewis acids which can activate several functional groups under extremely mild conditions. Gallium have been successfully employed acid catalysts various transformations such alkylation, allylation, radical reactions, cycloaddition Friedel–Craft's reactions coupling reactions. seeks update chemists about potential...

Aim: Stenotrophomonas maltophilia (Sm) and Burkholderia cepacia complex (BCC) are Gram-negative bacterial pathogens, which typically multidrug resistant excellent biofilm producers. These phenotypes controlled by quorum sensing (QS) systems from the diffusible signal factor (DSF) family. We aim to interfere with this QS system as an alternative approach in combatting such difficult-to-treat infections. Materials & methods: A library of sulfonamide-based DSF bioisosteres was synthesized...

This article describes the development and implementation of an open-access organic chemistry question bank for online tutorials assessments at University College Cork Dublin Institute Technology. SOCOT (structure-based tutorials) may be used to supplement traditional small-group tutorials, thereby allowing students develop essential problem-solving skills in chemistry. approach both formative summative assessment. Students complete one problem set weekly or fortnightly, which consists a...

Aim: Vibrio harveyi is a Gram-negative marine bacterium that model system in the study of quorum sensing (QS). V. uses multichannel QS, mediated by three signaling molecules. The aim this was to synthesize and screen diverse series furanones for their potential inhibit sensing. Materials & methods: A library halogenated prepared derivatized using standard Pd-mediated coupling reactions subsequently evaluated effects on bioluminescence. Results conclusion: Several inhibited QS-regulated...

The Diels-Alder reactions of 5-methoxyindenones with various α-pyrones provide the basis for a new and more efficient approach to synthesis unusual nor-diterpenoid tropone, harringtonolide.

An improved synthesis of the antiviral drug adefovir is presented. Problems associated with current routes to include capricious yields and a reliance on problematic reagents solvents, such as magnesium tert-butoxide DMF, achieve high conversions target. A systematic study within our laboratory led identification an iodide reagent which affords higher than previous approaches allows for reactions be conducted up 10 g in scale under milder conditions. The use novel tetrabutylammonium salt...