A5048429109- Biochemical and Molecular Research
- Cytomegalovirus and herpesvirus research
- Pulmonary Hypertension Research and Treatments
- Lung Cancer Diagnosis and Treatment
- RNA and protein synthesis mechanisms
- Systemic Sclerosis and Related Diseases
- Microbial Metabolic Engineering and Bioproduction
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Neonatal Health and Biochemistry
- Protein Structure and Dynamics
- Heavy Metal Exposure and Toxicity
- Adenosine and Purinergic Signaling
- Biotin and Related Studies
- HIV/AIDS drug development and treatment
- Effects and risks of endocrine disrupting chemicals
- Vascular Anomalies and Treatments
- Enzyme Structure and Function
- Hepatitis C virus research
Hospital South West Jutland
2025
Institut Pasteur
2023-2024
Université Paris Cité
2023-2024
Inserm
2024
Chimie ParisTech
2023
Centre National de la Recherche Scientifique
2023
American University of Beirut
2023
Pulmonary and Critical Care Associates
2022
Johns Hopkins Medicine
2022
Johns Hopkins University
2022
To date, it remains unclear whether recent changes in the management of patients with systemic sclerosis-associated pulmonary hypertension (SSc-PH) have improved survival.
De novo purine nucleotide biosynthesis (DNPNB) consists of sequential reactions that are majorly conserved in living organisms. Several regulation events take place to maintain physiological concentrations adenylate and guanylate nucleotides cells fine-tune the production response changing cellular demands. Recent years have seen a renewed interest DNPNB enzymes, with some being highlighted as promising targets for therapeutic molecules. Herein, review two newly revealed modes pathway has...
Binge eating disorder (BED) was recently recognised as a distinct diagnosis in Denmark. The estimated prevalence of BED the general population Denmark is 2-3%. among patients with type 2 diabetes (T2D) remains unknown. This small-scale preliminary cohort study aims to estimate obese T2D patients. Patients and BMI ≥ 30 kg/m² were recruited from Steno Diabetes Center Odense outpatient clinic. screened categorised into three groups using Eating Disorder Questionnaire follows: indication BED,...
In human cells, de novo purine nucleotide biosynthesis is known to be regulated through the formation of a metabolon called purinosome. Here, we employed bacterial two-hybrid approach characterize protein-protein interactions network among corresponding enzymes Escherichia coli. Our study revealed dense binary that connect most enzymes. Notably, PurK, an exclusive prokaryotic enzyme, appears as one central hubs this network. We further showed modifications in which disrupted several network,...
Inosine 5'-monophosphate (IMP) dehydrogenase (IMPDH) is an ubiquitous enzyme that catalyzes the NAD
Pulmonary arterial hypertension (PAH) is a serious and progressive vascular disease characterized by vasoconstriction, remodeling, inflammation.Despite considerable progress in the treatment of patients with PAH, long-term survival remains poor.Currently approved therapies target three well-characterized pathways involved pulmonary tone, poorly understood effect, if any, on remodeling.Over last two decades, novel implicated PAH remodeling pathogenesis have been unraveled.Such involve...