A5012494249- Nanoparticle-Based Drug Delivery
- Advanced Drug Delivery Systems
- RNA Interference and Gene Delivery
- Spinal Cord Injury Research
- Barrier Structure and Function Studies
- Advanced biosensing and bioanalysis techniques
- Cancer Treatment and Pharmacology
- Membrane-based Ion Separation Techniques
- Supramolecular Self-Assembly in Materials
- Nicotinic Acetylcholine Receptors Study
- Graphene and Nanomaterials Applications
- Cultural and Sociopolitical Studies
- Dendrimers and Hyperbranched Polymers
- Drug Solubulity and Delivery Systems
- Cell death mechanisms and regulation
- Nanoplatforms for cancer theranostics
- biodegradable polymer synthesis and properties
- Drug Transport and Resistance Mechanisms
- Adenosine and Purinergic Signaling
- Protein Hydrolysis and Bioactive Peptides
- Trace Elements in Health
- Bone and Joint Diseases
Hacettepe University
2012-2020
Ministry of Health
2019
Pharmaceutical Biotechnology (Czechia)
2009
Caspases play an important role as mediators of cell death in acute and chronic neurological disorders. Although peptide inhibitors caspases provide neuroprotection, they have to be administered intracerebroventricularly because cannot cross the blood–brain barrier (BBB). Herein, we present a nanocarrier system that can transfer chitosan nanospheres loaded with N -benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethyl ketone (Z-DEVD-FMK), relatively specific caspase-3 inhibitor,...
Although growth factors and anti-apoptotic peptides have been shown to be neuroprotective in stroke models, translation of these experimental findings clinic is hampered by limited penetration the brain. Here, we show that a large peptide like basic fibroblast factor (bFGF) small inhibitor caspase-3 (z-DEVD-FMK) can effectively transported brain after systemic administration incorporating brain-targeted nanoparticles (NPs). Chitosan NPs were loaded with then functionalized conjugating...
In this study, it was aimed to investigate characteristics and intracellular delivery of two different-sized PLGA nanoparticles in ouzo region by considering number nanoparticles. To determine the effect formulation parameters on average particle size, Dil labeled were prepared using a three-factor, two-level full factorial statistical experimental design. PLGA230 (230.8 ± 4.32 nm) PLGA160 (157.9 6.16 obtained altering polymer amount based design results characterized. Same per cell applied...
The blood-brain barrier (BBB) is the major problem for treatment of central nervous system diseases. A previous study from our group showed that brain-targeted chitosan nanoparticles-loaded with large peptide moieties can rapidly cross and provide neuroprotection. present aims to determine efficacy nanoparticles' uptake by human BBB cerebral microvessel endothelial cells (hCMECs) investigate underlying mechanisms enhanced cellular entry. Fluorescently labelled nanoparticles either conjugated...
Nano drug co-delivery system is a popular strategy for combined application of two or more anticancer and/or synergistic drugs. Synergistic effects nonsteroidal anti-inflammatory drugs and anti-cancer in cancer treatment are shown the literature. This study aimed to screen understand critical formulation process parameters preparation flurbiprofen paclitaxel co-loaded nanoparticles develop an nano system. With this aim, were determined using Plackett–Burman experimental design (DoE)....