A5103160338- Traumatic Brain Injury and Neurovascular Disturbances
- Spinal Cord Injury Research
- S100 Proteins and Annexins
- Pharmacological Effects and Toxicity Studies
- Meningioma and schwannoma management
- Bone and Joint Diseases
- Biochemical Acid Research Studies
- Pancreatitis Pathology and Treatment
- Lipid metabolism and disorders
- Peroxisome Proliferator-Activated Receptors
- Pregnancy-related medical research
- Acute Kidney Injury Research
- Vitamin C and Antioxidants Research
- Nerve injury and regeneration
- Adenosine and Purinergic Signaling
- Parasitic infections in humans and animals
- Neuroinflammation and Neurodegeneration Mechanisms
- Toxoplasma gondii Research Studies
- Macrophage Migration Inhibitory Factor
- Spinal Hematomas and Complications
- Spinal Dysraphism and Malformations
- Neurological and metabolic disorders
- Alcoholism and Thiamine Deficiency
- Thermal Regulation in Medicine
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
Memorial Ankara Hospital
2021
İstanbul Kanuni Sultan Süleyman Eğitim ve Araştırma Hastanesi
2019-2020
Ministry of Health
2020
Ankara Atatürk Eğitim ve Araştırma Hastanesi
2008-2019
Education Training And Research
2010
Ankara Numune Eğitim ve Araştırma Hastanesi
2004-2008
With important social and economic consequences, spinal cord injuries (SCIs) still exist among major health problems. Although many therapeutic agents methods investigated for the treatment of acute SCI, only high dose methylprednisolone (MP) is being used currently in practice. Due to serious side effects, systemic MP administration after SCI a critical issue that mostly considered controversial. In our study, it aimed develop nanoparticle-gel combined drug delivery system localization on...
The most common benign tumor of the brain is meningiomas. Usually diagnosed between ages 40-60, they are more in women. Studies have shown a strong relationship hormones and malignancies. Although meningiomas slow-growing tumors brain, pregnancy seems to induce its growth speed. concerning hormone may explain reason why symptoms during flare. More specifically, estrogen progesterone receptor take an active role through signal transduction inducing tumor. Thus, dilemma + meningioma arises. In...
The major aim of this study was to evaluate the efficiency chitosan microspheres containing cyclosporine-A (Cs-A) on mitochondrial damage in traumatic brain injury (TBI) animal model. Trauma introduced male Sprague-Dawley (SD) rats similar that modified Feeney Method. Briefly, after craniectomy left parietal region (5 mm). performed by dropping 24 g metal sterile rods through a teflon guide tube (9.3 cm) foot plate placed over duramater. Just trauma, 20 mg/kg Cs-A (Sandimmune®) has been...
Atorvastatin is commonly used as a cholesterol lowering agent in patients. Recently, the neuroprotective effects of atorvastatin became focus many research studies. In this study, we have formulated chitosan microspheres containing calcium. In-vitro characterization and quantification calcium from formulations were also evaluated. The efficiency was investigated by an experimental spinal cord injury model. implanted at laminectomy area (1 mg/kg) immediately after trauma. Twenty-four hours...
Spinal cord injury (SCI) is characterized by posttraumatic inflammatory cascades including excitotoxicity, oxidative stress, and apoptosis. Agents against neuroinflammation are the current scope of studies on experimental SCI with promising results.Thirty-two male Sprague-Dawley rats weighing 250-320 gram were used. They randomized divided into four groups eight animals in each as sham, control, SCI+PEG (polyethylene glycol) SCI+atorvastatin group. Rats anesthetized intraperitoneal ketamine...
The aggressive pathophysiology of SCI contributes to the extension this devastating condition.A mechanical trauma spinal cord triggers an immediate cascade cellular and biochemical events.Secondary injury processes that take place after neurological cause cell death by glutamate-induced exitotoxicity, inflammation, overproduction free oxygen radicals, mitochondrial dysfunction, energy failure apoptosis.Asiatic acid (AA) is a form triterpenoid, which isolated from Centella asiatica.It has...
In this research, the effect of tadalafil, a selective inhibitor cyclic guanosine monophosphate-specific phosphodiesterase type 5, on rats with spinal trauma was evaluated. The evaluation consisted neurological examination and biochemical parameters. Twenty healthy male Wistar albino were used in study. They separated into three groups: tadalafil-receiving (TD) group (n=7), laminectomy (LT) just (n=6). TD received daily dose tadalafil (10 mg/kg) for week along bait water. Each rat's cord...
Spinal Cord Injury (SCI) is a devastating health problem both for the patient and clinician. Numerous treatment modalities have been studied to reverse effects of spinal cord injury. Herein reported comparison Alpha Lipoic Acid N-Acetyl Cysteine on rats with SCI.38 adult male Sprague-Dawley were randomly divided into 5 groups: only laminectomy, laminectomy trauma, trauma 100 mg/kg IP administration, 300 vehicle group (PEG). The model was Modified Allen Weight drop method. After procedure,...
To evaluate the possible neuroprotective effects of systemic administration cyclosporine (Cyclosporin A) after traumatic brain injury in rats.The modified Feeney method was used as trauma model male Sprague Dawley rats. After trauma, 20 mg/kg administered to one group rats (n=12) intraperitoneally. Twenty-four hours injury, subjects were sacrificed, and samples removed. The level edema evaluated through wet-dry weight method, lipid peroxidation ratio, histological examination by transmission...
Abstract Background Neurological damage from spinal cord injury (SCI) is a result of primary mechanical and secondary oxidative stress neuroinflammation. Although genistein has been shown to have potent antioxidant anti-inflammatory effects in studies brain injury, its effect on SCI remained unknown. Objective To determine model rats. Methods We divided 21 rats evenly into 3 groups, control group, which only laminectomy was performed; trauma group induced; administered subcutaneously after...
Accurately locating small subcortical brain lesions is very important for maximal surgical resection with minimal neurological damage. Intraoperative MRI has proved to be more precise than ultrasound, it relatively expensive and not available in all centers. Herein we describe a new, simple, safe effective method determining skin incision craniotomy via staples combined intraoperative ultrasonography determine the margins, vascularity residue of lesion.Thirty-three patients were admitted...
Amaç: Deneysel omurilik yaralanmalarında hasarın takibi ve hücrelerin hasara yanıtını değerlendirmek ana unsurlardan biridir. Bu çalışmada iki farklı deneysel travma modelinde serum dokuda oksidan-antioksidan maddelerin değişimi incelenmiştir. Gereç yöntem: Çalışmada 3 grupta 6 adet Wistar rat kullanıldı. Kontrol grubuna (A grubu) sadece laminektomi yapıldı. Ağırlık (B ağırlık düşürme modeli ile, klip-kompresyon (C klip kompresyon tekniği ile spinal kord hasarı oluşturuldu. Fonksiyonel...