A5047447265- Antibiotics Pharmacokinetics and Efficacy
- Renal Transplantation Outcomes and Treatments
- Blood Pressure and Hypertension Studies
- HIV/AIDS drug development and treatment
- Analytical Chemistry and Chromatography
- Biosimilars and Bioanalytical Methods
- Analytical Methods in Pharmaceuticals
- Synthesis and Catalytic Reactions
- Transplantation: Methods and Outcomes
- Hemodynamic Monitoring and Therapy
- Steroid Chemistry and Biochemistry
- Neonatal Health and Biochemistry
- Pneumocystis jirovecii pneumonia detection and treatment
- Synthesis and pharmacology of benzodiazepine derivatives
- Cancer Treatment and Pharmacology
- Renin-Angiotensin System Studies
- Epilepsy research and treatment
- Biochemical and Molecular Research
- Synthesis and Reactions of Organic Compounds
- Noise Effects and Management
- Diet and metabolism studies
- Amino Acid Enzymes and Metabolism
- Synthesis and Biological Evaluation
- Pharmacological Effects and Toxicity Studies
- Receptor Mechanisms and Signaling
Medical University of Warsaw
2012-2023
Erasmus Hospital
2016
Tacrolimus (TAC) is post-transplant pharmacotherapy's most widely used immunosuppressant. In routine clinical practice, frequent uncomfortable venipuncture necessary for whole-blood (WB) collection to check trough TAC levels. Volumetric absorptive microsampling (VAMS) an alternative strategy WB collection. this study, we aimed validate and develop a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method quantification in VAMS samples. After extraction with water protein...
Abstract Background Mycophenolic acid (MPA) is widely used in posttransplant pharmacotherapy for pediatric patients after renal transplantation. Volumetric absorptive microsampling (VAMS) a recent approach sample collection, particularly during therapeutic drug monitoring (TDM). The recommended matrix MPA determination plasma (PL), and conversion between capillary-blood VAMS samples PL concentrations required the appropriate interpretation of results. Methods This study aimed to validate...
(1) Background: Only unbound tacrolimus particles are considered to be active and capable of crossing cellular membranes. Thus, the free-drug concentration might better associated with clinical effects than total drug used for dosage adjustment. We propose a new, fully validated online liquid chromatography-tandem mass spectrometry (LC-MS/MS) method measurement. (2) Methods: The determination in plasma ultrafiltrate was performed Nexera LC system LCMS-8050 triple quadrupole MS using...
In search for new drugs lowering arterial blood pressure, which could be applied in anti-hypertensive therapy, research concerning agents blocking of renin-angiotensin-aldosteron system has been conducted. Despite many years conducted at centers around the world, aliskiren is only one renin inhibitor, used up to now. Four novel potential inhibitors, having structure based on peptide fragment 8-13 human angiotensinogen, a natural substrate renin, were designed and synthesized. All these...
Dehydrogenaza inozynomonofosforanowa (IMPDH) pełni kluczową rolę w syntezie i metabolizmie nukleotydów purynowych szlaku de novo, szczególnie komórkach limfocytów typu B T. Wyróżniamy dwie izoformy tego enzymu (IMPDH I IMPDH II) kodowane przez różne geny, zlokalizowane na dwóch różnych chromosomach, przy czym druga izoforma dominuje szybko proliferujących limfocytarnych. Z powodu kliniczne znaczenie jest istotne zarówno terapii immunosupresyjnej, jak przeciwnowotworowej. Szeroko stosowane...
Seven novel potential renin inhibitors, having a structure based on the peptide fragment 8-13 of human angiotensinogen -a natural substrate for renin, have been designed and synthesized.All peptides were obtained by carbodiimide method in solution purified chromatography SiO 2 column.In P 1 -P 3 ' positions, they contain esters or N-alkyl amides modified (3S, 4S)-4-amino-3-hydroxyacids.The achieved inhibitory activity IC 50 was 10 -6 -10 -7 M Inhibitory compounds measured vitro...