Multicomponent reactions have gained significant importance as a tool for the synthesis of wide variety useful compounds, including pharmaceuticals. In this context, multiple component approach is especially appealing in view fact that products are formed single step, and diversity can be readily achieved simply by varying reacting components. The eco-friendly, solvent-free multicomponent opens up numerous possibilities conducting rapid organic functional group transformations more...

In this critical review, we provide a comprehensive view of the chemistry of<italic>ortho</italic>-quinone methides as versatile reactive intermediates in organic synthesis.

Decolouration of dilute solutions basic dye stuff was carried out using sugar cane dust as an adsorbent. It found that low adsorbate concentration, small particle size the adsorbent, a temperature 25°C and pH value 7.5 for medium all favour removal from aqueous solutions. The percentage adsorbed by decreased 96.48% to 83.32% 90.78% 78.02% Malachite Green Methylene Blue, respectively, when concentration increased 6 mg/l 12 mg/l. Similarly, adsorption Crystal Violet Rhodamine B also with...

An efficient and experimentally rapid protocol for the synthesis of hitherto unreported 2,3-dicarboalkoxy-4-aroyl/heteroaroyl/alkanoyl thiophenes has been developed via 1–2 (C–S) 3–4 (C–C) bond connections promoted by 4-dimethylaminopyridine (DMAP). Optimally, reaction takes only 3–5 min when β-oxodithioester dialkyl acetylenedicarboxylate are stirred in DCM at room temperature presence DMAP. This method allows a clean general previously inaccessible synthetically demanding containing...

An efficient and highly convergent route to dihydropyrimidinones (DHPMs) hitherto unreported dihydropyridopyrimidinones has been developed by one-pot, three-component cyclocondensation of aromatic aldehydes, β-oxodithioesters, urea/6-amino-1,3-dimethyluracil in the presence recyclable SiO2−H2SO4. On other hand, salicylaldehyde, β-oxodithioester, urea reacted under similar conditions afford 3-aroyl/heteroaroyl-2H-chromen-2-thiones high yields instead Biginelli product. The attractive feature...

Mandibular condylar cartilage plays a crucial role in temporomandibular joint (TMJ) function, which includes facilitating articulation with the disc and reducing loads on underlying bone. The experiences considerable tensile forces due to direct compression shear. However, only scarce information is available about its properties. present study aims quantify biomechanical characteristics of mandibular aid future three-dimensional finite element modeling tissue engineering studies. Porcine...

An efficient and convergent route to 3-aroyl-4-aryl-2-arylamino-4,6,7,8-tetrahydrochromen-5-ones hitherto unreported 3-aroyl-4-aryl-2-arylamino-4H-pyrano[3,2-c]chromen-5-ones has been developed by an one-pot three-component domino coupling of α-oxoketene-N,S-arylaminoacetals, aromatic aldehydes, dimedone/4-hydroxycoumarin in the presence DABCO under solvent-free conditions high yields. Further, suitably substituted pyrano[3,2-c]chromen-5-ones undergo intramolecular nucleophilic substitution...

A highly efficient one-pot three-component regioselective synthesis of 4-aryl-3-aroyl-2-methylsulfanyl-4,6,7,8-tetrahydrothiochromen-5-ones has been developed by annulation β-oxodithioesters with aldehydes and cyclic 1,3-diketones under solvent-free conditions promoted P(2)O(5). No cocatalyst or activator is needed in this protocol. The merit process highlighted its high efficiency producing three new bonds a stereocenter one operation.

Abstract The efficient, regioselective synthesis of functionalized/annulated quinolines was achieved by the coupling 2‐aminoaryl ketones with alkynes/active methylenes/α‐oxoketene dithioacetals promoted InCl 3 in refluxing acetonitrile as well under solvent‐free conditions excellent yields. This transformation presumably proceeded through hydroamination–hydroarylation alkynes, and Friedländer annulation active methylene compounds α‐oxoketene 2‐aminoarylketones. In addition, simple reductive...

Catalyst-free one-pot sustainable synthesis of thiazoloquinoline and thiazolopyridine scaffolds is achieved<italic>via</italic>four-component domino reactions in water–PEG.

An efficient, sustainable, and regioselective one-pot synthesis of hitherto unreported 4-aroyl/hetaroyl/alkanoyl-5-alkyl/allyl/benzylsulfanyl-1,2,3-thiadiazoles has been achieved by [3 + 2] cycloaddition α-enolicdithioesters with tosyl azide through cascade 1–2 (S–N) 3–4 (C–N) bond connections involving Wolff-type heterocyclization. Optimally, the reactions are very fast completed within 2–15 minutes, when a mixture α-enolicdithioester was stirred at 0 °C in presence Et3N under solvent-free...

Utilization of the fascinating properties β-oxodithioesters as building blocks in heterocyclic frameworks was started a few decades ago. Its similarity and dissimilarity with β-ketoesters terms its synthesis or substrate towards makes it an interesting emerging field synthetic organic chemistry. Tuning catalysts counter substrates selective utilization multiple reacting sites summarized following discussion. A diverse range monocyclic polycyclic heterocycles several different heteroatoms is...

An operationally simple and user-friendly new protocol for the synthesis of 3,5-disubstituted/annulated isothiazoles is devised utilizing β-ketodithioesters/β-ketothioamides NH4OAc via C═O/C═S bond functionalization under metal- catalyst-free conditions. The strategic [4 + 1] annulation initiated by carbon-economic relies on a sequential imine formation/cyclization/aerial oxidation cascade forming consecutive C–N S–N bonds in one pot. A wide range previously inaccessible synthetically...