Propargylamines are an important class of organic compounds that have been widely used as building blocks for the synthesis various kinds chemically and biologically relevant compounds. Over last few years, there a rapid growth in research dedicated to developing synthetic protocol propargylamine derivatives. Among methods reported propargylamines, three‐component coupling aldehyde, amine alkyne (commonly termed A 3 reactions) secured special place because its convenient/atom economical...

Abstract During the last one and half decades, chemists within vastly different areas of science have witnessed a rising interest in chemical matters incorporating sulfonimidamide functional group. New synthetic routes to sulfonimidamides been reported, utility these products has demonstrated synthetic, medicinal, agrochemical, material applications. In this review, we described synthesis their applications organic chemistry. magnified image

An efficient and experimentally rapid protocol for the synthesis of hitherto unreported 2,3-dicarboalkoxy-4-aroyl/heteroaroyl/alkanoyl thiophenes has been developed via 1–2 (C–S) 3–4 (C–C) bond connections promoted by 4-dimethylaminopyridine (DMAP). Optimally, reaction takes only 3–5 min when β-oxodithioester dialkyl acetylenedicarboxylate are stirred in DCM at room temperature presence DMAP. This method allows a clean general previously inaccessible synthetically demanding containing...

An efficient and highly convergent route to dihydropyrimidinones (DHPMs) hitherto unreported dihydropyridopyrimidinones has been developed by one-pot, three-component cyclocondensation of aromatic aldehydes, β-oxodithioesters, urea/6-amino-1,3-dimethyluracil in the presence recyclable SiO2−H2SO4. On other hand, salicylaldehyde, β-oxodithioester, urea reacted under similar conditions afford 3-aroyl/heteroaroyl-2H-chromen-2-thiones high yields instead Biginelli product. The attractive feature...

An efficient and convergent route to 3-aroyl-4-aryl-2-arylamino-4,6,7,8-tetrahydrochromen-5-ones hitherto unreported 3-aroyl-4-aryl-2-arylamino-4H-pyrano[3,2-c]chromen-5-ones has been developed by an one-pot three-component domino coupling of α-oxoketene-N,S-arylaminoacetals, aromatic aldehydes, dimedone/4-hydroxycoumarin in the presence DABCO under solvent-free conditions high yields. Further, suitably substituted pyrano[3,2-c]chromen-5-ones undergo intramolecular nucleophilic substitution...

A highly efficient one-pot three-component regioselective synthesis of 4-aryl-3-aroyl-2-methylsulfanyl-4,6,7,8-tetrahydrothiochromen-5-ones has been developed by annulation β-oxodithioesters with aldehydes and cyclic 1,3-diketones under solvent-free conditions promoted P(2)O(5). No cocatalyst or activator is needed in this protocol. The merit process highlighted its high efficiency producing three new bonds a stereocenter one operation.

Abstract An efficient, highly regioselective protocol for the synthesis of title compounds is reported. The reaction involves a one‐pot, three‐component cyclocondensation β‐oxodithioester, amine, and hydrazine in ethanol at reflux presence catalytic amount acetic acid. Densely functionalized pyrazoles were constructed through cyclization thioamide intermediate generated situ from β‐oxodithioester. This method allows rapid general previously inaccessible synthetically demanding containing fused rings.

Utilization of the fascinating properties β-oxodithioesters as building blocks in heterocyclic frameworks was started a few decades ago. Its similarity and dissimilarity with β-ketoesters terms its synthesis or substrate towards makes it an interesting emerging field synthetic organic chemistry. Tuning catalysts counter substrates selective utilization multiple reacting sites summarized following discussion. A diverse range monocyclic polycyclic heterocycles several different heteroatoms is...

A mild and metal-free approach has been developed for 1,2-difunctionalization of aryne using sulfenamides as a nucleophile halogen source (CX4) an electrophile to synthesize S-(o-halo)aryl sulfilimines. The late-stage functionalizations halide handles via Suzuki–Miyaura Buchwald–Hartwig reactions exhibit the synthetic utilities products. chemoselectivity, regioselectivity, rapidity, use economical CCl4 are advantages this protocol.

Herein, we present a metal-/catalyst-free, novel approach for S-sulfoximination of sulfenamide. The electrooxidative reactions sulfenamides and sulfoximines are fast, high-yielding, atom-economical (99.5%), broad-substrate-tolerant, free from supporting electrolytes. protocol is ecofriendly shows wider substrate tolerance than previous reports. drug-attached sulfenamide (levetiracetam) sulfoximine (albendazole) also undergo the reaction efficiently. A possible mechanistic pathway proposed....

Sulfenamides, as S(II) compounds, occupy a critical role in modern synthetic chemistry, driven by their multifaceted applications across pharmaceuticals, agrochemicals, and diverse industrial sectors. Functioning versatile intermediates, sulfenamides facilitate broad array of transformations, including oxidation, amination, sulfuration, underscoring utility complex molecular construction. This review presents an in‐depth analysis sulfenamide synthesis, reactivity patterns, multifarious...

Metal-free, p-toluenesulfonic acid (p-TSA)-mediated, straightforward propargylation of β-ketothioamides with aryl propargyl alcohol has been achieved at room temperature. In addition, the reaction also provided thiazole rings as byproducts. Furthermore, propargylated thioamides undergo intramolecular 1,5-cyclization to afford fully substituted (hydro)thiophenes in presence base. Notably, approach is pot, atom, and step economical (PASE).

Abstract Herein, sulfonimidamide (SIA) has been used as directing group for ortho ‐chlorination of arene N ‐aroyl part SIA. The Pd‐mediated protocol uses ‐chlorosuccinimide (NCS) oxidant/chlorine source, and acetic acid solvent. products are obtained in moderate to good yields.

A facile and efficient InCl3 catalyzed one-pot synthesis of highly substituted pyrroles has been developed via a tandem propargylation/cycloisomerization reaction α-oxoketene-N,S-acetals with propargyl alcohols. Notably, in the presence Bronsted acid p-TSA·H2O, afforded hydrolyzed product propargylated-1,3-dicarbonyl compounds, which upon treatment Cs2CO3 underwent regioselective intramolecular cyclization furnishing tetrasubstituted furan derivatives.