Abstract The efficient, regioselective synthesis of functionalized/annulated quinolines was achieved by the coupling 2‐aminoaryl ketones with alkynes/active methylenes/α‐oxoketene dithioacetals promoted InCl 3 in refluxing acetonitrile as well under solvent‐free conditions excellent yields. This transformation presumably proceeded through hydroamination–hydroarylation alkynes, and Friedländer annulation active methylene compounds α‐oxoketene 2‐aminoarylketones. In addition, simple reductive...

An efficient, sustainable, and regioselective one-pot synthesis of hitherto unreported 4-aroyl/hetaroyl/alkanoyl-5-alkyl/allyl/benzylsulfanyl-1,2,3-thiadiazoles has been achieved by [3 + 2] cycloaddition α-enolicdithioesters with tosyl azide through cascade 1–2 (S–N) 3–4 (C–N) bond connections involving Wolff-type heterocyclization. Optimally, the reactions are very fast completed within 2–15 minutes, when a mixture α-enolicdithioester was stirred at 0 °C in presence Et3N under solvent-free...

Leishmaniases are an epidemic in various countries, and the parasite is developing resistance against available drugs. Thus, development of new drugs Leishmania open area investigation for synthetic organic chemists. To meet this challenge, a series chromene-2-thione derivatives have been synthesized docked into active site trypanothione reductase (TryR) enzyme required redox balance parasite. These were screened on promastigote, axenic amastigote, intracellular amastigote stages donovani...

A highly convergent and regioselective heteroannulation protocol for the synthesis of hitherto unreported substituted 2-amino-4-(aryl/alkyl)-5-(aroyl/heteroaroyl)-3-(cyano/carboalkoxy)-6-methylthio-4H-thiopyran derivatives has been developed. This one-pot three-component domino coupling β-oxodithioesters, aldehydes, malononitrile/ethyl or methyl cyanoacetate is promoted by 4-dimethylamino pyridine (DMAP) in solvent (dichloromethane (DCM)) as well under solvent-free conditions. Systematic...

A facile and efficient synthesis of 3-aroyl/heteroaroyl/ferrocenoyl/alkanoyl-2H-chromen-2-ones has been developed by the cyclocondensation α-oxoketene dithioacetals 2-hydroxyarylaldehydes catalyzed InCl3 under solvent-free conditions. No co-catalyst or activator is needed MeSH only by-product this protocol. The methodology involves ring annulation with a variety offering rapid entry into differentially substituted chromen-2-ones. condensation ferrocene derived dithioacetal...

Solvent-free mechanochemical route to naphtho[2,3-b]thiophenes via [3 + 2] oxidative heteroannulation of α-enolicdithioesters and β-oxothioamides with 1,4-naphthoquinone has been achieved at room temperature.

1,1′-Bis(1,1-dimethylsulfanyl-3-oxo-1-propene)ferrocene and 1,1′-Bis(methyl-3-hydroxy-prop-2-ene-dithioate)ferrocene have been shown to be useful three-carbon synthons for the efficient synthesis of hitherto unreported synthetically demanding Fc-heterocycles. Five-membered (pyrazole, isoxazole, thiophene) six-membered (pyrimidine, coumarin, quinoline) heterocycles constructed on both Cp rings ferrocene matrix via regioselective heteroaromatic annulation.

A fluorescent molecule DANP that binds to cytosine bulge DNA and emits characteristic fluorescence was conjugated pyrene give a new probe PyDANP. Temperature- solvent-dependent absorption changes showed chromophores stacked at room temperature in an aqueous buffer solution quenched fluorescence. Upon binding of moiety PyDANP DNA, the from bound C-bulge increased by ∼12-fold, showing is turn-ON for detection DNA.

Abstract A simple and efficient synthesis of previously unknown benzosubstituted dioxaphosphonines containing a quinoxaline subunit is described. Reasonably good yields the products, mild reaction conditions, convenient work-up are advantages this method. The procedure does not require any catalyst or activator can be efficiently achieved via dianion cyclization. All synthesized compounds have been characterized by satisfactory elemental analyses spectral (IR, 1H, 13C, 31P NMR, mass)...

Abstract A simple and fast, one‐step, cost effective protocol for silver nanoparticle (AgNP) synthesis has been reported. AgNO 3 is reduced using black cardamom (B.C.) extract to produce nanoparticles. Variable size nanoparticles were obtained by choosing the different composition of a reaction mixture comprised solution B.C. extract. Nanoparticle formation was monitored color change as well UV‐Visible spectroscopy. AgNPs characterized thoroughly XRD TEM analysis shape size. plausible...

Abstract In our ongoing studies on the synthesis of new heterocyclic ring systems via a dianion intermediate, we herein describe preparation novel dibenzoazadioxoninone, dibenzoazadioxoninethione, dibenzoazadioxocine, dibenzoazadioxacycloundecine, dibenzoazadioxacyclododecine, dibenzoaza-2-oxodioxaphosphonine, and dibenzoaza-2-oxo-1,3-thioxaphosphonine in good yields.

Abstract Photolyases are flavoenzymes responsible for light-driven repair of carcinogenic crosslinks formed in DNA by UV exposure. They possess two non-covalently bound chromophores: flavin adenine dinucleotide (FAD) as a catalytic center and an auxiliary antenna chromophore that harvests photons transfers solar energy to the center. Although transfer reaction has been characterized time-resolved spectroscopy, it is strikingly important understand how well natural biological systems organize...

Abstract Methyl 2‐carbamate‐1,8‐naphthyridine thiophenolate derivative (NCTP) has been designed and synthesized, which can selectively bind to guanine derivatives. We immobilized NCTP on gold electrode performed cyclic voltammetry analysis for guanosine sensing. The current blockage data obtained from these electrodes suggest that have higher selectivity 2’‐deoxyguanosine monophosphate (dGMP) than 2’‐deoxythymidine (dTMP), 2’‐deoxycytidine (dCMP), 2’‐deoxyadenosine monophophate (dAMP). Thus,...