A5101587917- Vanadium and Halogenation Chemistry
- Thallium and Germanium Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Trace Elements in Health
- Reproductive Biology and Fertility
- Radiopharmaceutical Chemistry and Applications
- Sperm and Testicular Function
- Fluoride Effects and Removal
- Per- and polyfluoroalkyl substances research
- Mercury impact and mitigation studies
- Heavy Metal Exposure and Toxicity
- Metal-Catalyzed Oxygenation Mechanisms
- Air Quality and Health Impacts
- Philosophical and Cultural Analysis
- Inflammatory mediators and NSAID effects
- Philosophical Thought and Analysis
- Fullerene Chemistry and Applications
- Environmental Toxicology and Ecotoxicology
- Plant Parasitism and Resistance
- Higher Education Teaching and Evaluation
- Urological Disorders and Treatments
- Effects and risks of endocrine disrupting chemicals
- Selenium in Biological Systems
- Carcinogens and Genotoxicity Assessment
- Hemophilia Treatment and Research
Universidad Nacional Autónoma de México
2006-2024
Universidad de Zaragoza
2023
Centro de Estudios Superiores Universitarios
2022
Universitat Politècnica de València
2017-2020
Instituto de Biología Molecular y Celular de Plantas
2017-2020
Universidad Nacional de Córdoba
2018
Universidad Panamericana
2012
Universidad de León
2010
Stony Brook University
1996
State University of New York
1996
Perfluorooctanoic acid (PFOA) is a member of the perfluoroalkyl family compounds. Due to presence strong carbon-fluorine bonds, it practically nonbiodegradable and highly persistent in environment. PFOA has been detected follicular fluid women, positively associated with reduced fecundability infertility. However, there are no reports concerning experimental evaluation on oocyte toxicity mammals. The aim present study was determine if able induce oxidative stress fetal ovaries cause...
The increased concentration of thallium (Tl) in the environment is a cause for concern because entire population, including pregnant women, exposed, and this metal crosses placenta reaches conceptus during development. In biological models such as mice, some abnormalities delays ossification occur fetuses mice administered Tl on day 7 gestation, but exposure to environmental constant fetal development; therefore, study, effects several administrations TI organogenesis external morphology,...
Vanadium (V) has garnered attention due to its pharmacological properties; however, toxic effects have also been documented. Among the vanadium compounds that are found in environment, trioxide (V2O3) attracted interest because of impact on biomolecules such as DNA, RNA, and proteins. However, precise mechanism action remains unclear, although it is suspected be related oxidative stress. Therefore, this study aimed determine mechanisms involved DNA damage associated cellular response...
Vanadium (V) is a metal that can enter the environment through natural routes or anthropogenic activity. In atmosphere, V present as oxides, among which vanadium(III) oxide (V2O3) stands out. Cytogenetic studies have shown V2O3 genotoxic and cytostatic induces DNA damage; however, molecular mechanisms leading to these effects not been fully explored. Therefore, we treated human peripheral blood lymphocytes in vitro, evaluated of on phases cell cycle expression molecules control examined...
Thallium is a non-essential metal with wide range of industrial uses. However, thallium also potential pollutant high toxicity to humans. In the present study, we analyzed and compared cellular genotoxic effects in two main oxidation states by applying chromosome aberration assays human peripheral lymphocytes. We observed that thallium(I) sulfate reduced mitotic index at all tested concentrations (0.5, 1, 5, 50 100 μg/mL), whereas thallium(III) chloride was toxic ≥1 μg/mL. Thallium(I)...
Fly ash, the inorganic residue resulting from combustion of some fuels, may almost exclusively contain vanadium oxides, compounds which exert potential toxic effects on a wide variety in vitro and vivo biological systems. Because information related to oxidation state responsible for inducing genotoxic is controversial, aim present study was evaluate three salts vitro. Human peripheral lymphocyte cultures were exposed 1, 2, 4, or 8 μg/mL vanadium(III) trioxide, vanadium(IV) tetraoxide,...
Research on the biological effects of vanadium in humans has shown that acute poisoning workers can manifest itself a number symptoms. There are no reports about reproductive and developmental induced by compounds humans; however, some studies with rats mice indicate cross placental barrier accumulate fetal membranes rather than fetus itself. In this case, probably most consequences administration to pregnant females like reabsorptions, death reduction size be result maternal toxicity....
Vanadium is a strategic metal that has many important industrial applications and generated by the use of burning fossil fuels, which inevitably leads to their release into environment, mainly in form oxides. The wastes represent major health hazard. Furthermore, it attracted attention because several genotoxicity studies have shown some vanadium compounds can affect DNA; among most studied pentoxide, but
Although thallium is detrimental to all living organisms, information regarding the mutagenic and genotoxic effects of this element its compounds remains scarce. Therefore, we tested cytotoxic thallium(I) acetate on human peripheral blood cells in vitro using structural chromosomal aberrations (SCAs), sister chromatid exchanges (SCEs), single-cell gel electrophoresis (at pH >13 or 12.1) analysis. Whole samples were incubated with 0.5, 1, 5, 10, 50, 100 µg/mL salt. Exposure metal compound...
A variety of metal ions have biological functions, and many researchers not actively investigated copper compounds, based on the assumption that endogenous metals might be less toxic. In present study, we used a dual fluorochrome method single cell gel electrophoresis (SCGE) assay at pH > 13 to evaluate viability DNA damage induced by copper-based antineoplastic drug, Casiopeina II-gly®, concentrations 1.04, 2.08, 4.17, 8.35 or 16 μg/mL in human peripheral-blood leukocytes vitro. We observed...
More than 12,000 plant species (ca. 10% of flowering plants) exude latex when their tissues are injured. Latex is produced and stored in specialized cells named "laticifers". Laticifers form a tubing system composed rows elongated that branch create an internal network encompassing the entire plant. constitute recent evolutionary achievement ecophysiological adaptation to specific natural environments; however, fitness benefit still remains be proven. The identification
Forty captive Mallards (Anas platyrhynchos), of both sexes, were separated into five groups and dosed with lead shot via oral intubation; one group was used as a control. Lead dosage differed in terms number size, well administration time. One hundred thirty-five wild mallards trapped between 1998 2001 the Boada Nava lagoons near Canal de Castilla, Spanish province Palencia. Radiologic techniques (ventrodorsal lateral views) to detect gizzard determine degradation birds over Heparinized...
Vanadium is a widely distributed metal in the Earth's surface and released into environment by either natural or anthropogenic causes. (III) oxide (V2O3) present environment, many organisms are exposed to this compound; however, its effects at cellular genetic levels still unknown. Therefore, study, ability of V2O3 induce chromosomal damage impair cell proliferation was tested on human leukocytes vitro. The cultures cells were treated for 48 h with different concentrations 2, 4, 8 16 μg/mL...
Abstract Background The evaluation of the DNA damage generated in cumulus cells after mature cumulus-oocyte complexes vitrification can be considered as an indicator oocyte quality since these play important roles developmental competence. Therefore, aim this study was to determine if matured exposure cryoprotectants (CPAs) or affects oocytes and viability, but also is cells, affecting fertilization embryo development. Results measured using alkaline comet assay expressed Comet Tail Length...
In vitro assays have demonstrated that vanadium compounds interact with biological molecules similar to protein kinases and phosphatases also shown oxides decrease the proliferation of cells, including human lymphocytes; however, mechanism, phase in which cell cycle is delayed proteins involved this process are unknown. Therefore, we evaluated effects (V2 O3 , V2 O4 O5 ) lymphocyte cultures (concentrations 2, 4, 8, or 16 μg/ml) on cellular levels p53, p21 Cdc25C proteins. After 24 h...
Casiopeina III-Ea® (Cas III-Ea®) is a chelated copper complex with antineoplastic activity that capable of reducing tumor size and inducing antiproliferative apoptotic effects. However, little known about its in vivo genotoxic Therefore, this study evaluated two cytogenetic proliferative parameters 24 h after the administration to male CD-1 mice. Three doses Cas were administered by intraperitoneal injections 1.69, 3.39 6.76 mg/kg (corresponding 1/8, 1/4 1/2 LD50, respectively). A reduction...