A5070847211- Hematopoietic Stem Cell Transplantation
- Aldose Reductase and Taurine
- Acute Myeloid Leukemia Research
- Heme Oxygenase-1 and Carbon Monoxide
- Advanced Glycation End Products research
- Chronic Myeloid Leukemia Treatments
- Multiple Myeloma Research and Treatments
- Acute Lymphoblastic Leukemia research
- Renal Transplantation Outcomes and Treatments
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Sulfur Compounds in Biology
- Immune Cell Function and Interaction
- Metabolism, Diabetes, and Cancer
- Organ Transplantation Techniques and Outcomes
- Prenatal Substance Exposure Effects
- Hepatitis C virus research
- Nitric Oxide and Endothelin Effects
- Cannabis and Cannabinoid Research
- Diet, Metabolism, and Disease
- Neonatal Health and Biochemistry
- Adenosine and Purinergic Signaling
- Monoclonal and Polyclonal Antibodies Research
- Pancreatitis Pathology and Treatment
- Connective Tissue Growth Factor Research
University of Birmingham
2016-2025
Cancer Research UK Clinical Trials Unit
2016-2023
Bristol-Myers Squibb (Switzerland)
2019
Novartis (Switzerland)
2019
Takeda (Japan)
2019
Jazz Pharmaceuticals (United States)
2019
Janssen (Switzerland)
2019
Takeda (Netherlands)
2019
Amgen (Netherlands)
2019
International Network for Cancer Treatment and Research
2019
Reduced-intensity conditioning (RIC) regimens have extended the curative potential of allogeneic stem-cell transplantation to older adults with high-risk acute myeloid leukemia (AML) and myelodysplasia (MDS) but are associated a high risk disease relapse. Strategies reduce recurrence urgently required. Registry data demonstrated improved outcomes using sequential transplant regimen, fludarabine/amsacrine/cytarabine-busulphan (FLAMSA-Bu), impact this intensified regimen has not been studied...
Allogeneic stem-cell transplant allows for the delivery of curative graft-versus-leukemia (GVL) in patients with acute myeloid leukemia/myelodysplasia (AML/MDS). Surveillance T-cell chimerism, measurable residual disease (MRD) and blast HLA-DR expression may inform whether GVL effectiveness is reduced. We report here prognostic impact these biomarkers allografted AML/MDS. One hundred eighty-seven from FIGARO, a randomized trial reduced-intensity conditioning regimens AML/MDS, were alive...
Increased flux of glucose through the polyol pathway may cause generation excess reactive oxygen species (ROS), leading to tissue damage. Abnormalities in expression enzymes that protect against oxidant damage accentuate oxidative injury. The catalase (CAT), CuZn superoxide-dismutase (CuZnSOD), glutathione peroxidase (GPX), and Mn (MnSOD) mRNA was quantified peripheral blood mononuclear cells—obtained from 26 patients with type 1 diabetes nephropathy, 15 no microvascular complications after...
Salvage options for patients who relapse after allogeneic stem-cell transplantation (allo-SCT) acute myeloid leukemia (AML) and myelodysplasia (MDS) remain limited, novel treatment strategies are required. Both lenalidomide (LEN) azacitidine (AZA) possess significant antitumor activity effect in AML. Administration of LEN post-transplantation is associated with excessive rates graft-versus-host disease (GVHD), but AZA has been shown to ameliorate GVHD murine models. We therefore examined the...
Graft-versus-host disease (GvHD) remains a major complication of allogeneic stem cell transplantation (allo-SCT), affecting 30-70% patients (representing 800 new per year in the UK). The risk is higher undergoing unrelated allo-SCT. About 1 10 die as result GvHD or through complications its treatment. In who survive and treatment, about 3 develop chronic which has negative impact on quality life (QoL). Many transplant protocols use alemtuzumab anti-thymocyte globulin (ATG) combination with...
OBJECTIVE—Increased production of reactive oxygen species (ROS) in diabetes is thought to play a major role the pathogenesis diabetic microvascular complications such as nephropathy and retinopathy. The NAD(P)H oxidase complex an important source ROS vasculature. p22 subunit polymorphic with C242T variant that changes histidine-72 for tyrosine potential heme binding site, together A640G 3′ untranslated region. aim was investigate frequency these polymorphisms 268 patients type 1 or without...
The expression of aldose reductase is tightly regulated by the transcription factor tonicity response element binding protein (TonEBP/NFAT5) to three osmotic elements (OREs; OREA, OREB, and OREC) in gene. aim was investigate contribution NFAT5 pathogenesis diabetic nephropathy. Peripheral blood mononuclear cells (PBMCs) were isolated from following subjects: 44 Caucasoid patients with type 1 diabetes, whom 26 had nephropathy 18 no after a diabetes duration 20 years, 13 normal healthy control...
Several cell surface molecules have hepatitis C virus (HCV) binding properties and may serve as receptors facilitating viral entry into cells. The large extracellular loop (LEL) of CD81 has been shown to bind the HCV envelope protein E2 with several critical residues for CD81‐HCV‐E2 interaction. It was hypothesised that variation in LEL sequence modify susceptibility infection. RNA negative patients spontaneous clearance (RNA −ve); positive cases, who are affected chronically +ve); at high...
To investigate whether high glucose induces myo-inositol oxygenase (MIOX) expression in peripheral blood mononuclear cells through transcription factors, nuclear factor of activated T 5 (NFAT5) and carbohydrate response element binding protein (ChREBP), which may contribute to the pathogenesis diabetic nephropathy. 34 patients with type 1 diabetes mellitus (20 nephropathy, 14 without complications) 9 healthy controls were recruited this study. Peripheral exposed normal, conditions...
Transcriptional activity of connective tissue growth factor (CTGF) promoter in transfected HEK293 cells was determined by luciferase assays. Secreted CTGF cultured human mesangial measured enzyme-linked immunosorbent assay (ELISA). urine and plasma also 405 subjects with/without type 2 diabetes. Our results showed that high glucose significantly increased transcription the more than 2.5-folds (p < 0.0005). secretion induced These increases were inhibited simvastatin. Urine positively...
HCV is a major cause of liver disease worldwide. IL-12 plays an essential role in the balance T helper 1 (Th1) differentiation versus 2 (Th2) driven response from its naïve precursor. Linkage disequilibrium measures degree to which alleles at two loci are associated and non-random associations between loci. Haplotypes three IL-12B studied were determined patient cases normal healthy control subjects. The frequency 12 possible haplotypes on 3 was subjects heterozygous only one within...