A5088621587- Diabetes and associated disorders
- Diabetes Management and Research
- Pancreatic function and diabetes
- Gestational Diabetes Research and Management
- Aldose Reductase and Taurine
- Heme Oxygenase-1 and Carbon Monoxide
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Dental Erosion and Treatment
- Ovarian function and disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Sulfur Compounds in Biology
- Prenatal Substance Exposure Effects
- Abdominal Surgery and Complications
- Enhanced Recovery After Surgery
- Advanced Glycation End Products research
- Inhalation and Respiratory Drug Delivery
- Calpain Protease Function and Regulation
- Pharmaceutical studies and practices
- Lipid metabolism and disorders
- Dental Anxiety and Anesthesia Techniques
- Maternal and Perinatal Health Interventions
- Alcohol Consumption and Health Effects
Intermountain Healthcare
2024
King's College Hospital
2020
Peninsula College of Medicine and Dentistry
2003-2018
University of Exeter
2018
Derriford Hospital
2014-2015
University Hospitals Plymouth NHS Trust
2015
University of Plymouth
1993-2014
Peninsula Health
2005
University of Birmingham
1994-1997
King's College School
1988-1994
The transcription factor insulin promoter factor-1 (IPF-1) plays a central role in both the development of pancreas and regulation gene expression mature pancreatic β cell. A dominant-negative frameshift mutation IPF-l was identified single family shown to cause agenesis when homozygous maturity-onset diabetes young (MODY) heterozygous. We studied IPF-1 Caucasian diabetic nondiabetic subjects from United Kingdom. Three novel missense mutations (C18R, D76N, R197H) were patients with type 2...
The relative contributions to modern European populations of Paleolithic hunter-gatherers and Neolithic farmers from the Near East have been intensely debated. Haplogroup R1b1b2 (R-M269) is commonest Y-chromosomal lineage, increasing in frequency east west, carried by 110 million men. Previous studies suggested a origin, but here we show that geographical distribution its microsatellite diversity best explained spread single source via Anatolia during Neolithic. Taken with evidence on...
There is very little published information on the severity of tooth wear in children. The current investigation involved clinical examination 101 children and an assessment their dietary habits. Evidence was found over 80% maxillary incisor teeth, 30% primary molar teeth had some dentine exposed. were 21 who regarded as having 'mild' erosion, 45 'moderate' erosion 35 'severe' erosion. highly statistically significant differences between three groups relation to drinking habits; mean number...
Use of a splint-mounted flexible pH electrode has allowed reliable continuous monitoring at the surface dentition whilst still enabling subjects to drink normally. was monitored palatal upper left central incisor and right first permanent molar sites after drinking 1% (w/v) citric acid. A maximal decrease in values 2-3 observed 1 min followed by slower recovery which above 5.5 within 2 former site 4-5 latter site. sharp rise parotid saliva flow rate seen same concentration acid glass, straw...
Recent studies suggest that the gene encoding aldose reductase (ALR2), enzyme converts glucose to sorbitol, may confer susceptibility microvascular disease. DNA from 275 British Caucasian patients with type I diabetes and 102 normal healthy control were typed for a (CA)n dinucleotide repeat polymorphic marker in 5'-region of ALR2 using polymorase chain reaction (PCR). A highly significant decrease frequency Z+2 allele was found nephropathy (nephropathy group) compared those no complications...
GLIS3 (GLI-similar 3) is a member of the GLI-similar zinc finger protein family encoding for nuclear with 5 C2H2-type domains. The expressed early in embryogenesis and plays critical role as both repressor activator transcription. Human mutations are extremely rare.The purpose this article was determine phenotypic presentation 12 patients variety mutations.GLIS3 gene were sought by PCR amplification sequence analysis exons 1 to 11. Clinical information provided referring clinicians...
<h3>OBJECTIVES</h3> There is evidence that the polyol pathway involved in pathogenesis of diabetic neuropathy. Aldose reductase (ALR2) first and rate limiting enzyme this recent studies have suggested polymorphisms around gene are associated with development microvascular disease. The aim was to examine role ALR2 susceptibility neuropathy patients insulin dependent diabetes mellitus (IDDM). <h3>METHODS</h3> One hundred fifty nine British white IDDM 102 normal healthy controls were studied...
Variation within the calpain-10 gene (CAPN10) has been proposed to account for linkage type 2 diabetes on chromosome 2q in Mexican-Americans, and associations with have reported several other populations. Given epidemiological, physiological, genetic overlap between polycystic ovary syndrome (PCOS), CAPN10 represents a strong candidate role PCOS susceptibility. Using both family based case-control association resources (146 parent-offspring trios; 185 additional cases; 525 control subjects,...
We have produced a soluble form of mouse alpha beta T-cell antigen receptor (TCR) by shuffling its variable (V) and constant (C) domains to the C region an immunoglobulin kappa light chain. These chimeric molecules composed V chains were efficiently secreted (up 1 micrograms/ml) transfected myeloma cells as noncovalent heterodimers about 95-kDa molecular mass. In absence direct binding measurement, we refined epitopic analysis kappa-V dimers shown that they react with anti-clonotypic...
Background The treatment of people with diabetes metformin can reduce cardiovascular disease (CVD) and may the risk cancer. However, it is unknown whether or not these outcomes in elevated blood glucose levels below threshold for [i.e. non-diabetic hyperglycaemia (NDH)]. Objective To assess feasibility Glucose Lowering In Non-diabetic Trial (GLINT) to estimate key parameters inform design full trial. These include recruitment strategy, randomisation, electronic data capture, postal drug...
Recent studies have shown that loci outside the HLA region are involved in determining susceptibility to type 1 diabetes. Polymorphisms coding and noncoding regions of genes encoding cytokines may be modulating immune response self nonself antigens. There is increasing evidence an imbalance disruption Th1 Th2 T cell subsets play a key role development experimental clinical The aim this study was investigate frequency CA dinucleotide repeat polymorphism interferon-gamma (IFN-gamma) gene...