A5052740474- Down syndrome and intellectual disability research
- Alzheimer's disease research and treatments
- Treatment of Major Depression
- Chronic Disease Management Strategies
- Dementia and Cognitive Impairment Research
- Genetic Associations and Epidemiology
- Chronic Kidney Disease and Diabetes
- Renin-Angiotensin System Studies
- Diabetes and associated disorders
- Food Allergy and Anaphylaxis Research
- Preterm Birth and Chorioamnionitis
- Genetic diversity and population structure
- Allergic Rhinitis and Sensitization
- Library Science and Information Literacy
- Polysaccharides Composition and Applications
- Neuroscience and Neuropharmacology Research
- Botanical Research and Chemistry
- Cardiovascular Issues in Pregnancy
- Library Collection Development and Digital Resources
- Connective Tissue Growth Factor Research
- Frailty in Older Adults
- Heat shock proteins research
- Immune Cell Function and Interaction
- Contact Dermatitis and Allergies
- Trace Elements in Health
Coventry University
2008-2020
Birmingham City University
2020
South Essex Partnership University Foundation NHS Trust
2011-2015
University of Birmingham
2001-2011
University of South Carolina
2008
Heartlands Hospital
2001-2004
University of Plymouth
1996
St. Mary's Hospital
1996
Centre for Mental Health
1996
King's College School
1993
Virtually all adults with Down syndrome (DS) have neuropathological manifestations of Dementia in Alzheimer's disease (DAD) but not develop clinical psychopathology. The effect allelic variants Apolipoprotein (APOE) gene development and progression DAD mortality persons DS is examined.Recruited participants underwent two to 14 sequential assessments over a follow up period 6 years on average their APOE genotype determined. status was confirmed as recommended by the Working Group for...
Abstract Aims We hypothesize that transforming growth factor‐beta (TGF‐β), a multifunctional factor which plays key role in the development of tissue fibrosis, may be involved pathophysiology diabetic nephropathy. Our aim was to examine three polymorphisms within TGF‐β1 gene, codons 10, 25 and 263, for association with nephropathy Type 1 diabetes. Methods conducted large case–control study using cases diabetes clinical Controls were subjects who have been injecting insulin at least 50 years...
Down's syndrome (DS) is caused by either complete or partial triplication of chromosome 21, affecting approximately 1/1000 live births, and it widely accepted that individuals with DS are more likely to develop dementia Alzheimer's disease (DAD) compared the general population. Recent collaborative genome-wide association studies large case control data sets without Alzhemier's (AD) have revealed new risk variants for dementia, as well confirming previously identified variants. In this...
Objectives: Previous research has demonstrated that α2 agonists improve working memory performances in healthy individuals and primates with prefrontal lesions. We conducted this study to determine whether the agonist, guanfacine, could patients frontal lobe epilepsy (FLE) and/or those focal outside lobes (ie, temporal [TLE]). Methods: Fourteen FLE, 13 TLE, 10 controls completed immediate delayed match-to-sample tasks before after ingestion of 2 3 mg guanfacine. Results: All groups showed an...
Plasma concentrations of HDL (high-density lipoprotein) cholesterol are low in the Saudi Arabian population. A B polymorphism at CETP (cholesteryl ester protein transfer) locus that is detectable with restriction enzyme TaqI a genetic determinant plasma concentration. We assessed relationship between and lipid apolipoprotein study sample 335 residents. The B1 B2 allele frequencies were 0.54 0.46 respectively, similar to those other populations. levels B2B2 homozygotes significantly higher...
Abstract Background The risk for dementia in Alzheimer's disease (DAD) adults with Down syndrome (DS) is higher than the general adult population. Hypercholesterolaemia has been reported as a factor DAD This study investigated role of serum cholesterol levels onset DS Methods total 179 persons (with and without DAD). possible association between Apolipoprotein E amyloid β 1‐40 1‐42 was also investigated. Results No statistically significant found AD or levels. However an apoE ε 4 allele...
One hundred and twelve patients suffering from moderate to severe major depression (DSM III) were enrolled into a study compare the antidepressant activity side effect profiles of two dosage groups minaprine (200 mg 300 per day) one imipramine (150mg in psychiatric practice. - Eight withdrawn because unwanted effects (four imipramine, 200 mg, three mg) seventy-eight spontaneous reports made group compared with sixty-four forty-six groups. The main efficacy analysis was carried out at 4 weeks...
A very large number of therapeutic trials antidepressant drugs have been reported in the scientific literature.Until now, comparison one drug with another, or placebo, has performed typically by comparing scores on depression rating scales two groups patients at fixed points time after beginning therapy. It was postulated 1989 that curves recovery followed an exponential curve formula y = ae-bx + c. This hypothesis tested a double-blind controlled trial minaprine, use Hamilton Rating Scale...
plots and bias were analyzed for the rest of thyroid assays as well fertility oncology assays.Pooled estimates within-run imprecision replicate results calculated in each segments.The are summarized Fig. 1F.The precision ACS:Centaur system was demonstrated to be equivalent that ACS:180 system.Diagnostic concordance between systems also verified using patients with within reference interval.Diagnostic thyroid, fertility, on Ͼ96% all assays.Data from regression analysis diagnostic studies...