A5081179690- Nanoplatforms for cancer theranostics
- Luminescence and Fluorescent Materials
- Photodynamic Therapy Research Studies
- Molecular Sensors and Ion Detection
- Advanced Drug Delivery Systems
- Hydrogels: synthesis, properties, applications
- Photochromic and Fluorescence Chemistry
- Electrospun Nanofibers in Biomedical Applications
- Photoreceptor and optogenetics research
- Polymer Surface Interaction Studies
- Biosensors and Analytical Detection
- Marine and Coastal Ecosystems
- Mining and Resource Management
- Advanced biosensing and bioanalysis techniques
- 3D Printing in Biomedical Research
- Nanocomposite Films for Food Packaging
- Antimicrobial agents and applications
- Advanced Nanomaterials in Catalysis
- Advanced Polymer Synthesis and Characterization
- Advancements in Transdermal Drug Delivery
- Ocular Surface and Contact Lens
- Coastal and Marine Management
- Synthesis and Properties of Aromatic Compounds
- Neurobiology and Insect Physiology Research
- Healthcare and Environmental Waste Management
Caraga State University
2017-2025
Chosun University
2017-2021
In this work, antioxidant hydrogels were prepared by the construction of an interpenetrating chitosan network and functionalization with gallic acid. The poly(2-hydroxyethyl methacrylate) p(HEMA)-based first synthesized subsequently surface-modified polymer (IPN) structure methacrylamide via free radical polymerization. resulting chitosan-IPN surface-functionalized acid through amide coupling reaction, which afforded hydrogels. Notably, gallic-acid-modified based on a longer backbone...
A series of four lactose-modified BODIPY photosensitizers (PSs) with different substituents (-I, -H, -OCH3, and -NO2) in the para-phenyl moiety attached to meso-position core were synthesized; photophysical properties photodynamic anticancer activities these sensitizers investigated, focusing on electronic substituent groups. Compared parent H, iodine substitution (BODIPY I) enhanced intersystem crossing (ISC) produce singlet oxygen (1O2) due heavy atom effect, maintained a high fluorescence...
The straightforward synthesis of three cationic boron-dipyrromethene (BODIPY) derivatives and their mitochondria-targeting photodynamic therapeutic (PDT) capabilities are reported. Two cancer cell lines (HeLa MCF-7) were used to investigate the PDT activity dyes. Compared non-halogenated counterparts, halogenated BODIPY dyes exhibit lower fluorescence quantum yields enable efficient production singlet oxygen species. Following LED light irradiation at 520 nm, synthesized displayed good...
This study examines the perceived health impacts of a mining company on residents Libjo, Dinagat Islands, Philippines, addressing critical research gap in understanding activities underrepresented regions. The operations were examined using qualitative approach, employing semi-structured interviews. interview instrument was developed to investigate how impact key determinants, such as water quality, sanitation, income, employment, infrastructure, education, and women’s empowerment. conducted...
Microplastics have garnered attention for their ubiquitous presence across various ecosystems, yet investigations into occurrence in mangrove environments, particularly the Philippines, remain minimal and increasingly necessary. This study seeks to establish a foundational understanding of microplastic distribution Philippine forests, with special focus on Butuan Bay. Surface water sediment samples were collected from habitats City, Buenavista, Nasipit along Bay, Southern Philippines....
A series of hydrogels with intrinsic antifouling properties was prepared via surface-functionalization poly(2-hydroxyethyl methacrylate) [p(HEMA)]-based the biomembrane-mimicking zwitterionic polymer, poly(2-methacryloyloxyethyl phosphorylcholine) [p(MPC)]. The p(MPC)-modified have enhanced surface wettability, high water content retention (61.0%-68.3%), and good transmittance (>90%). Notably, presence MPC moieties at hydrogel surfaces lowered adsorption proteins such as lysozyme bovine...
A series of 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene-based photosensitizers (AmBXI, X = H, M, Br) featuring a cationic mitochondrion-targeting group and near-infrared (NIR) absorption was synthesized. After extending the photosensitizers' π conjugation via Knoevenagel reaction, both absorbance emission maxima AmBXI shifted to phototherapeutic wavelength range (650-900 nm). Theoretical computations indicate that introduction bromine atoms promotes spin-orbit coupling, so for each additional...
The synthesis of three water-soluble lactose-modified 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY)-based photosensitizers with tumor-targeting capabilities is reported, including an investigation into their photodynamic therapeutic activity on distinct cancer cell lines (human hepatoma Huh7, cervical HeLa, and breast MCF-7 lines). halogenated BODIPY dyes exhibited a decreased fluorescence quantum yield compared to non-halogenated counterpart, facilitated the efficient generation...
ABSTRACT A facile synthetic strategy was developed for the preparation of thermoresponsive nanocomposite hydrogels comprising crosslinked chitosan (CS) networks and poly( N ‐isopropylacrylamide) [p(NIPAAm)] nanogels. First, p(NIPAAm) nanogels were synthesized via emulsion polymerization. The introduced into methacrylamide CS (MC) solution free‐radical initiated crosslinking reaction MC produced nanogel‐embedded hydrogels. last step involves loading antibacterial model drug levofloxacin (LFX)...
In this study, a series of rationally designed emissive phenanthrene derivatives were synthesized and their aggregation-induced emission (AIE) properties in tetrahydrofuran (THF)/water mixtures investigated. Two tetraphenylethene (TPE) segments conjugated to both ends the core at para-positions meta-positions, resulting pTPEP mTPEP derivatives, respectively. While TPE-conjugated did not show any when dissolved pure THF, they showed strong sky-blue emissions water-THF mixtures, which is...
Abstract The bicontinuous microemulsion contact lens (BMCL) has nanoporous biphasic structures (100–250 nm) that are interconnected via multiple nano‐channels, providing suitable retention of various drugs for glaucoma. Timolol maleate (TM)‐carried thermosensitive poly( N ‐isopropylacrylamide) (PNIPAM) nanogel (30–50 was incorporated into BMCLs by soaking or centrifuging plus soaking. Here, we present drug‐loading and release in silicon‐ polyethylene oxide‐microemulsion under conditions....
Herein, the preparation of cross‐linked copolymer hydrogels composed various weight ratios 2‐methacryloyloxyethyl phosphorylcholine (MPC) and 2‐hydroxyethyl methacrylate (HEMA) monomers employing free‐radical polymerization was reported. The integration MPC monomer into HEMA‐based showed good transmittance (>90%) enhanced water content retention (79–202%) relative to those pure hydrogel. Notably, MPC‐containing (MPC‐H) exhibited improved anti‐biofouling properties due formation a compact...
Abstract A series of four lactose-modified BODIPY photosensitizers (PSs) with different substituents (-I, -H, -OCH 3 , and -NO 2 ) in the para -phenyl moiety attached to meso -position core were synthesized; photophysical properties photodynamic anticancer activities these sensitizers investigated, focusing on electronic substituent groups. Iodine substitution (BODIPY I enhanced intersystem crossing (ISC) produce singlet oxygen ( 1 O due heavy atom effect, maintained a high fluorescence...