A5036238840- Protease and Inhibitor Mechanisms
- S100 Proteins and Annexins
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Diabetic Foot Ulcer Assessment and Management
- CRISPR and Genetic Engineering
- Sulfur Compounds in Biology
- Genomics, phytochemicals, and oxidative stress
- Phytochemicals and Antioxidant Activities
- Fungal Infections and Studies
- Medical and Biological Ozone Research
- Vitamin C and Antioxidants Research
- Blood Coagulation and Thrombosis Mechanisms
- Virus-based gene therapy research
- Circular RNAs in diseases
- Heme Oxygenase-1 and Carbon Monoxide
- Peptidase Inhibition and Analysis
- Antimicrobial Peptides and Activities
- Viral gastroenteritis research and epidemiology
- Neutropenia and Cancer Infections
- Respiratory viral infections research
- Tracheal and airway disorders
- Endoplasmic Reticulum Stress and Disease
- Cancer-related molecular mechanisms research
- Antioxidant Activity and Oxidative Stress
- Chronic Obstructive Pulmonary Disease (COPD) Research
Universitat de València
2019-2024
INCLIVA Health Research Institute
2018-2024
Menéndez Pelayo International University
2023
Hospital Universitari i Politècnic La Fe
2011
Primary ciliary dyskinesia (PCD) is a rare heterogenous condition that causes progressive suppurative lung disease, chronic rhinosinusitis, otitis media, infertility and abnormal situs. 'Better Experimental Approaches to Treat Ciliary Dyskinesia' (BEAT-PCD) network of scientists clinicians coordinating research from basic science through clinical care with the intention developing treatments diagnostics lead improved long-term outcomes for patients. BEAT-PCD activities are supported by EU...
Alpha-1 antitrypsin deficiency (AATD) is a neutrophilic inflammatory disorder that may result in local hypoxia, reactive oxygen and nitrogen species (ROS/RNS) production, increased damage adjacent tissues. This study aims to determine the impact of hypoxia on neutrophil oxidative stress profile AATD patients. Neutrophils were isolated from patients control volunteers exposed (1% O2 for 4 h), ROS/RNS, mitochondrial parameters, non-enzymatic antioxidant defenses measured by flow cytometry. The...
Several studies have shown the importance of oxidative stress (OS) in respiratory disease pathogenesis. It has been reported that nasal epithelium may act as a surrogate for bronchial several diseases involving OS. However, sample yields obtained from biopsies are modest, limiting number parameters can be determined. Flow cytometry widely used to evaluate cellular OS profiles. advantage analyses performed using small amount sample. Therefore, we aimed set up new method based on flow assess...
Alpha-1 antitrypsin deficiency (AATD) is an inflammatory disorder where neutrophils play a key role. Excessive neutrophil activation leads to local hypoxia and tissue damage. Most research on function has been conducted under atmospheric conditions (21% O
Caspofungin and liposomal amphotericin B (L-ampho B) have shown similar efficacy for the treatment of persistent febrile neutropenia (PFN). Although patients undergoing allogeneic stem cell transplantation (allo-SCT) are at high risk life-threatening invasive fungal infections (IFI), specific data on best choice antifungal agent in this setting scarce.The aim present study was to analyse caspofungin L-ampho used as empirical PFN two consecutive historical cohorts allo-SCT a single...
<b>Introduction:</b> The ability of neutrophils to damage adjacent tissues is related their activation status. Excessive neutrophil leads degranulation and increases the oxygen (O2) intake, leading local hypoxia an increase in reactive species (ROS) that contribute tissue injury. Alpha-1 antitrypsin deficiency (AATD) a rare genetic condition can produce lung liver some patients. We have previously shown oxidative stress involved pathophysiology AATD. This study was aimed determine whether...
<b>Introduction:</b> Alpha-1 antitrypsin (AATD) deficiency is an inherited condition that leads to decreased circulating AAT levels, significantly increasing the risk of lung and liver disease. AATD underdiagnosed. Severity symptoms in patients are highly variable neither protein levels nor phenotype sufficient identify which will develop and/or Therefore, new strategies biomarkers for early diagnosis prognosis disease needed. <b>Rationale Aims:</b> MicroRNAs (miRNAs) regulate gene...
<b>Introduction:</b> The emergence some years ago of the CRISPR/Cas9 system allowed gene therapy to be specific, versatile, cheap and approachable almost every laboratory. Due these features, many different genetic diseases such as cystic fibrosis or β-thalassemia have been addressed in cellular models using editing tool. Alpha-1 antytripsin deficiency (AATD) is a rare condition that can provoke respiratory hepatic symptoms. Z allele SERPINA1 well-characterised point mutation trigger whole...
<b>Introduction:</b> Alpha-1 antitrypsin (AAT) protein is the most abundant protease inhibitor in serum, but it also presents immunomodulator and anti-inflammatory activity. AAT expression codified by the <i>SERPINA1</i> gene. Mutations this gene lead to deficiency (AATD), a highly underdiagnosed respiratory condition. mainly produced by hepatocytes and, smaller quantities, neutrophils, monocytes, or alpha beta-pancreatic cells, among others. Natural killer cells (NK) are type of...
<b>Introduction:</b> Alpha-1 antitrypsin deficiency (AATD) is a rare respiratory condition characterized by abnormal inflammation, where neutrophils play key role. Excessive neutrophil activation leads to an increase in the oxygen (O<sub>2</sub>) intake, causing local hypoxia and increased tissue-injury capacity. Tissue part of inflammatory process so can function effectively under these conditions. However, mechanisms which mediate tissue damage remain unclear. The study aimed determine...