A5079628025- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV, Drug Use, Sexual Risk
- HIV/AIDS drug development and treatment
- COVID-19 epidemiological studies
- Sex work and related issues
- Adolescent Sexual and Reproductive Health
- SARS-CoV-2 detection and testing
- COVID-19 Clinical Research Studies
- Viral Infections and Outbreaks Research
- Medication Adherence and Compliance
- HIV-related health complications and treatments
- Census and Population Estimation
- SARS-CoV-2 and COVID-19 Research
- HIV/AIDS Impact and Responses
- Data-Driven Disease Surveillance
- Hepatitis C virus research
Nigeria Centre for Disease Control
2016-2024
Centers for Disease Control and Prevention
2022
Center for Global Health
2022
Centers for Disease Control and Prevention
2021
Federal Medical Centre
2019
The Nigerian Antiretroviral therapy (ART) program started in 2004 and now ranks among the largest Africa. However, nationally representative data on outcomes have not been reported.We evaluated retrospective cohort from a sample of adults aged ≥15 years who initiated ART during to 2012. Data were abstracted 3,496 patient records at 35 sites selected using probability-proportional-to-size (PPS) sampling. Analyses weighted controlled for complex survey design. main outcome measures mortality,...
The observed epidemiology of SARS-CoV-2 in sub-Saharan Africa has varied greatly from that Europe and the United States, with much lower reported incidence. Population-based studies are needed to estimate true cumulative incidence inform public health interventions. This study estimated seroprevalence four selected states Nigeria October 2020. We implemented a two-stage cluster sample household survey Nigerian (Enugu, Gombe, Lagos, Nasarawa) age-stratified prevalence antibodies. All...
Objective Although geographically specific data can help target HIV prevention and treatment strategies, Nigeria relies on national- state-level estimates for policymaking intervention planning. We calculated sub-state along the continuum of care in Nigeria. Design Using from HIV/AIDS Indicator Impact Survey (NAIIS) (July–December 2018), we conducted a geospatial analysis estimating three key programmatic indicators: prevalence infection among adults (aged 15–64 years); antiretroviral...
Background The Nigeria AIDS Indicator and Impact Survey (NAIIS), a cross-sectional household survey, was conducted in 2018 with primary objectives to estimate HIV prevalence, HIV-1 incidence, status of UNAIDS 90-90-90 cascade. We retrospective analysis the performance rapid tests national testing algorithm used Nigeria. Methods included Determine HIV-1/2 as test 1 (T1), Unigold 2 (T2), StatPak tie-breaker (T3). Individuals reactive T1 either T2 or T3 were considered HIV-positive....
Nigeria has the fourth largest burden of HIV globally. Key populations, including female sex workers, men who have with men, and people inject drugs, are more vulnerable to than general population due stigmatized criminalized behaviors. Reliable key size estimates needed guide epidemic response efforts.The objective our study was use empirical methods for sampling analysis improve quality drugs in 7 states (Akwa Ibom, Benue, Cross River, Lagos, Nasarawa, Rivers, Federal Capital Territory)...
Background ATCC HIV-1 drug resistance test kit was designed to detect (HIVDR) mutations in the protease and reverse transcriptase genes for all group M subtypes circulating recombinant forms. The has been validated both plasma dried blood spot specimen types with viral load (VL) of ≥1000 copies/ml. We performed an in-country assessment on determine genotyping sensitivity its accuracy detecting HIVDR using samples stored under suboptimal conditions. Methods Among 572 VL copies/ml that had...
Treatment success requires both a sustainable supply of Antiretroviral Therapy (ART) to clinics and lifelong adherence treatment by patients. Poor medication may lead failure as result developing HIV resistance strains. Based on WHO 2014 guideline, over 26 million people will be additionally enrolled globally. Optimal identification patients with suboptimal for targeted intervention. The aim the study was determine predictors non-adherence ART.An unmatched 1:2 case-control 68 cases using...
Abstract Objective Viral load suppression (VLS) is critical in reducing morbidity and mortality associated with HIV as well minimizing the likelihood of transmission to uninfected persons. The objective this study was identify factors VLS among people living (PLWH) on antiretroviral (ARV) therapy inform programme strategies Nigeria. Methods Adult participants, aged 15–64 years, from 2018 Nigeria HIV/AIDS Indicator Impact Survey (NAIIS), who self‐reported be a PLWH or had detectable ARVs,...
Although there are a number of studies comparing the currently recommended preferred and alternative first-line (1L) antiretroviral therapy (ART) regimens on clinical outcomes, limited data examining impact 1L regimen choice duration virologic failure (VF) accumulation drug resistance mutations (DRM). The patterns DRM from patients failing zidovudine (AZT)-containing versus tenofovir (TDF)-containing ART were assessed to evaluate predicted susceptibility second-line (2L) nucleoside...
As antiretroviral treatment (ART) coverage for people living with HIV (PLHIV) increases, programmes require up-to-date information about evolving risk behaviour and transmission risk, including those low-level viremia (LLV; >50 to ≤1000 copies/mL), guide prevention priorities. We aimed assess differences in sexual behaviours, distribution of viral load (VL) proportion across PLHIV subgroups. analysed data from Population-based Impact Assessment surveys 14 sub-Saharan African countries...
Human Immunodeficiency Virus (HIV) diagnosis remains the gateway to HIV care and treatment. However, due changes in prevalence testing coverage across different geopolitical zones, it is crucial evaluate national algorithm as false positivity low could be detrimental both client service delivery. Therefore, we evaluated performance of rapid using specimens collected from multiple services (HTS) sites compared results levels six zones Nigeria. The evaluation employed a dual approach,...
We identified a HIV-positive cohort in virologic failure (VF) who re-suppressed without drug switch. characterized their resistance mutations (DRM) and adherence profiles to learn how better manage HIV resistance. A retrospective study utilizing clinical data stored samples. Patients received ART at three Nigerian treatment centres. Plasma samples when they were VF genotyped.
Abstract Nigeria relies on data from periodic resource-intensive surveys such as antenatal HIV seroprevalence sentinel (ANC-HSS) and population-based National AIDS Reproductive Health Surveys (NARHS) for its control efforts. has not explored the use of readily available routine programmatic (RPD) to easily inform monitor epidemic efforts at local settings in near real time. This study aimed determine utility RPDs (Prevention Mother-To-Child Transmission [PMTCT] Testing Counseling [HTC]) a...
<sec> <title>BACKGROUND</title> Nigeria has the fourth largest burden of HIV globally. Key populations (KP) including female sex workers (FSW), men who have with (MSM), and people inject drugs (PWID) often poor social visibility are more vulnerable to than general population due stigma, discrimination, criminalization KP-defining behaviors. Reliable, empirical size estimates (PSE) needed guide focused appropriately scaled epidemic response efforts for KP. We used novel approaches sampling...