Orji Bassey
A5076247800- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- HIV Research and Treatment
- COVID-19 epidemiological studies
- HIV/AIDS drug development and treatment
- Viral Infections and Outbreaks Research
- Adolescent Sexual and Reproductive Health
- Vaccine Coverage and Hesitancy
- Virology and Viral Diseases
- Mosquito-borne diseases and control
- HIV/AIDS Impact and Responses
- Data-Driven Disease Surveillance
- Computational Drug Discovery Methods
- Malaria Research and Control
Nigeria Centre for Disease Control
2011-2024
Centers for Disease Control and Prevention
2015-2024
Centers for Disease Control and Prevention
2021-2022
Commercially available HIV-1 drug resistance (HIVDR) genotyping assays are expensive and have limitations in detecting non-B subtypes circulating recombinant forms that co-circulating resource-limited settings (RLS). This study aimed to optimize a low cost broadly sensitive in-house assay HIVDR mutations the protease (PR) reverse transcriptase (RT) regions of pol gene. The overall plasma sensitivity was 95.8% (N = 96). Compared original two commercially systems, TRUGENE® ViroSeq®, optimized...
Abstract Background To accelerate progress toward the UNAIDS 90-90-90 targets, US Centers for Disease Control and Prevention Nigeria country office (CDC Nigeria) initiated an Antiretroviral Treatment (ART) Surge in 2019 to identify link 340,000 people living with HIV/AIDS (PLHIV) ART. Coronavirus disease (COVID-19) threatened interrupt ART following detection of first case February 2020. overcome this disruption, CDC designed implemented adapted strategies during February–September Methods...
HIV cross-sectional surveys require multi-layered testing with several tests to estimate prevalence and HIV-1 incidence. We evaluated the performance accuracy of newly developed Triplex assay diagnose HIV-2 detect recent infections using plasma samples from 2018 Nigeria AIDS Indicator Impact Survey (NAIIS). Plasma consenting HIV-positive (n=2,773) a subset HIV-negative (n=7,196), as determined by national rapid algorithm, followed Bio-Rad Geenius HIV-1/2 Supplemental Assay Western Blot, aged...
Rubella infection during pregnancy can result in miscarriage or infants with a constellation of birth defects known as congenital rubella syndrome (CRS). When coverage is inadequate, vaccination increase CRS cases by increasing the average age infection. Thus, World Health Organisation recommends that countries introducing vaccine be able to vaccinate at least 80% each cohort. Previous studies have focused on national-level analyses and overlooked sub-national variation introduction risk. We...
In 2018, an estimated 1.8 million persons living in Nigeria had HIV infection (1.3% of the total population), including 1.1 (64%) who were receiving antiretroviral therapy (ART) (1).Effective ART reduces morbidity and mortality rates among with prevents transmission once viral load is suppressed to undetectable levels (2,3).In April 2019, through U.S. President's Emergency Plan for AIDS Relief (PEPFAR),* CDC launched 18-month Surge program nine Nigerian states rapidly increase number ART.CDC...
Background The Nigeria AIDS Indicator and Impact Survey (NAIIS), a cross-sectional household survey, was conducted in 2018 with primary objectives to estimate HIV prevalence, HIV-1 incidence, status of UNAIDS 90-90-90 cascade. We retrospective analysis the performance rapid tests national testing algorithm used Nigeria. Methods included Determine HIV-1/2 as test 1 (T1), Unigold 2 (T2), StatPak tie-breaker (T3). Individuals reactive T1 either T2 or T3 were considered HIV-positive....
Background: Non-cold chain-dependent HIV rapid testing has been adopted in many resource-constrained nations as a strategy for reaching out to populations. test kits (RTKs) have the advantage of ease use, low operational cost and short turnaround times. Before 2005, different RTKs had used Nigeria without formal evaluation. Between 2005 2007, study was conducted formally evaluate number construct algorithms. Objectives: The objectives this were assess select develop national Method: Nine...
Ineffective linkage to care (LTC) is a known challenge for community HIV testing. To overcome this challenge, robust strategy was adopted by the 2018 Nigeria HIV/AIDS Indicator and Impact Survey (NAIIS). The NAIIS further adapted improve Nigeria's programmatic efforts achieve 1st 90 as part of Antiretroviral Therapy (ART) Surge initiative, which also included targeted In paper we provide an overview LTC describe impact on both initiatives.The collaborated with community-based organizations...
Data on awareness of HIV status among people living with (PLHIV) are critical to estimating progress toward epidemic control. To ascertain the accuracy self-reported and antiretroviral drug (ARV) use in Nigeria HIV/AIDS Indicator Impact Survey (NAIIS), we compared rapid diagnostic test (RDT) results ARV detectable blood levels.
Studying the genetic diversity and natural polymorphisms of HIV-1 would benefit our understanding HIV drug resistance (HIVDR) development predict treatment outcomes. In this study, we have characterized at 5' region pol gene encompassing protease (PR) reverse transcriptase (RT) from 271 plasma specimens collected in 2008 HIV-1-infected patients who were eligible for initiating antiretroviral therapy Abuja (Nigeria). The analysis indicated that predominant subtype was G (31.0%), followed by...
Multiplex assays for malaria antigen detection can gather data from large sample sets, but considerations the consistency and quality assurance (QA) of mass testing lack evaluation. We present a QA framework study occurring November 2019 to March 2020 involving 504 assay plates detecting four Plasmodium antigens: pan-Plasmodium aldolase lactate dehydrogenase (LDH), histidine-rich protein 2 (HRP2), P. vivax LDH (PvLDH). Controls on each plate included buffer blank, negative blood, 4-point...
Background: HIV testing remains an entry point into care and treatment services. In 2007, Nigeria adopted implemented a two-test rapid algorithm of three test kits, following the sequence: Alere Determine (first test), UnigoldTM (second STAT-PAK® as tie-breaker. Sub-analysis 2018 HIV/AIDS Indicator Impact Survey data showed significant discordance between first second tests, necessitating evaluation algorithm. This manuscript highlights lessons learnt from that evaluation.Intervention: A...
ABSTRACT Rubella infection during pregnancy can result in miscarriage or infants with a constellation of birth defects known as congenital rubella syndrome (CRS). When coverage is inadequate, vaccination increase CRS cases by increasing the average age infection. Thus, World Health Organisation recommends that countries introducing vaccine be able to vaccinate at least 80% each cohort. Previous studies have focused on national-level analyses and overlooked sub-national variation introduction...
Human Immunodeficiency Virus (HIV) diagnosis remains the gateway to HIV care and treatment. However, due changes in prevalence testing coverage across different geopolitical zones, it is crucial evaluate national algorithm as false positivity low could be detrimental both client service delivery. Therefore, we evaluated performance of rapid using specimens collected from multiple services (HTS) sites compared results levels six zones Nigeria. The evaluation employed a dual approach,...
Background: HIV drug resistance (HIVDR) surveillance is an important tool to monitor threats progress towards epidemic control. The characterization of HIVDR in Nigeria at the national level needed inform both clinical decisions and population-level policy strategies. This study uses data obtained from HIV/AIDS Indicator Impact Survey (NAIIS) describe prevalence distribution Nigeria. Methods: NAIIS was a cross-sectional, population-based survey households throughout 2018. designed provide...
Background: HIV transmission can occur with viral load (VL) ≥200 copies/mL and low-level viremia (LLV) lead to virologic failure; the level at which risk for failure is conferred uncertain. To better understand LLV prevalence outcomes, we analyzed retrospective longitudinal data from a large cohort of people living (PLHIV) on ART in Nigeria.Methods: We estimated rates suppression (≤50 copies/mL), (51–999 non-suppression (≥1,000 (≥2 consecutive results) among PLHIV ≥18 years who initiated...