A5077073665- HIV/AIDS Research and Interventions
- SARS-CoV-2 and COVID-19 Research
- HIV, Drug Use, Sexual Risk
- COVID-19 epidemiological studies
- HIV Research and Treatment
- Mosquito-borne diseases and control
- Malaria Research and Control
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Adolescent Sexual and Reproductive Health
- Cytomegalovirus and herpesvirus research
- Diverse Scientific Research Studies
- Global Maternal and Child Health
- Viral Infections and Outbreaks Research
- Complement system in diseases
- Data-Driven Disease Surveillance
- Syphilis Diagnosis and Treatment
- Virology and Viral Diseases
- HIV/AIDS Impact and Responses
- Parasites and Host Interactions
- Food Security and Health in Diverse Populations
- COVID-19 diagnosis using AI
- Hepatitis B Virus Studies
- HIV-related health complications and treatments
- Artificial Intelligence in Healthcare
Nigeria Centre for Disease Control
2021-2025
Centers for Disease Control and Prevention
2022-2024
Centers for Disease Control and Prevention
2021-2022
Center for Global Health
2022
United States Agency for International Development
2014-2015
Accurate SARS-CoV-2 serological assays are critical for COVID-19 serosurveillance. However, previous studies have indicated possible cross-reactivity of these assays, including in areas where malaria is endemic.
Abstract Background To accelerate progress toward the UNAIDS 90-90-90 targets, US Centers for Disease Control and Prevention Nigeria country office (CDC Nigeria) initiated an Antiretroviral Treatment (ART) Surge in 2019 to identify link 340,000 people living with HIV/AIDS (PLHIV) ART. Coronavirus disease (COVID-19) threatened interrupt ART following detection of first case February 2020. overcome this disruption, CDC designed implemented adapted strategies during February–September Methods...
Abstract Plasmodium falciparum (Pf) is the dominant malaria parasite in Nigeria though P. vivax (Pv), ovale (Po), and malariae (Pm) are also endemic. Blood samples (n = 31,234) were collected from children aged 0-14 years during a 2018 nationwide HIV survey assayed for antigenemia, DNA, IgG against MSP1-19 antigens. Of all children, 6.6% estimated to have Pm infection 1.4% Po with no Pv infections detected. The highest household wealth quintile was strongly protective (aOR: 0.11, 95% CI:...
Background Knowledge, attitude and practices (KAP) towards COVID-19 can directly impact healthcare workers’ (HCWs) services efforts to contain the spread of disease. This study assessed KAP among HCWs (laboratorians, doctors, nurses pharmacists) in Nigeria from August December 2022. Method A facility-based cross-sectional was conducted on 1341 7 facilities across 3 states Nigeria. were selected using a stratified random sampling technique. structured questionnaire including sociodemographic...
HIV cross-sectional surveys require multi-layered testing with several tests to estimate prevalence and HIV-1 incidence. We evaluated the performance accuracy of newly developed Triplex assay diagnose HIV-2 detect recent infections using plasma samples from 2018 Nigeria AIDS Indicator Impact Survey (NAIIS). Plasma consenting HIV-positive (n=2,773) a subset HIV-negative (n=7,196), as determined by national rapid algorithm, followed Bio-Rad Geenius HIV-1/2 Supplemental Assay Western Blot, aged...
In 2018, an estimated 1.8 million persons living in Nigeria had HIV infection (1.3% of the total population), including 1.1 (64%) who were receiving antiretroviral therapy (ART) (1).Effective ART reduces morbidity and mortality rates among with prevents transmission once viral load is suppressed to undetectable levels (2,3).In April 2019, through U.S. President's Emergency Plan for AIDS Relief (PEPFAR),* CDC launched 18-month Surge program nine Nigerian states rapidly increase number ART.CDC...
The observed epidemiology of SARS-CoV-2 in sub-Saharan Africa has varied greatly from that Europe and the United States, with much lower reported incidence. Population-based studies are needed to estimate true cumulative incidence inform public health interventions. This study estimated seroprevalence four selected states Nigeria October 2020. We implemented a two-stage cluster sample household survey Nigerian (Enugu, Gombe, Lagos, Nasarawa) age-stratified prevalence antibodies. All...
As at 2019, Nigeria was ranked the fourth highest HIV burden in world. There is varied geographical prevalence Nigeria. The progress made inequitable across locations and sub-populations (18). Benue state has second In 2018, about 35,623 people living with (PLHIV) were yet to commence antiretroviral treatment (ART) state, accounting for an estimated ART coverage gap of 11% out combined 320,921 country. To close this gap, surge (BAS) implemented. aim study describe BAS strategic approaches...
Background The Nigeria AIDS Indicator and Impact Survey (NAIIS), a cross-sectional household survey, was conducted in 2018 with primary objectives to estimate HIV prevalence, HIV-1 incidence, status of UNAIDS 90-90-90 cascade. We retrospective analysis the performance rapid tests national testing algorithm used Nigeria. Methods included Determine HIV-1/2 as test 1 (T1), Unigold 2 (T2), StatPak tie-breaker (T3). Individuals reactive T1 either T2 or T3 were considered HIV-positive....
Serosurveillance can provide estimates of population-level exposure to infectious pathogens and has been used extensively during the COVID-19 pandemic. Simultaneous, serological testing for multiple be done using bead-based immunoassays add value disease-specific serosurveys. We conducted a validation four SARS-CoV-2 antigens-full-length spike protein, two receptor binding domain proteins, nucleocapsid protein-on our existing multiplex bead assay (MBA) enteric diseases, malaria, vaccine...
Plasmodium falciparum malaria is a leading cause of child mortality in Nigeria. Neonates are born with maternal antibodies from placental transfer which may protect against infection the first months life. The IgG dynamics transition passively transferred antimalarial to actively acquired natural exposure have not been well elucidated.Blood samples collected during 2018 Nigeria nationwide HIV/AIDS household survey were available for 9,443 children under 5 years age, subset infants 2 age...
Congenital transmission of Toxoplasma gondii can occur when a woman becomes infected for the first time during or just before pregnancy. in fetus lead to miscarriage, stillbirth, ocular neurological abnormalities at birth, progressive visual, hearing, motor, and cognitive deficiencies. The national seroprevalence T. infection Nigeria was previously unknown. 2018 HIV/AIDS Indicator Impact Survey collected demographic, socioeconomic, HIV-related data stored blood specimens with consent future...
Nigeria has one of the highest HIV burdens as well mother-to-infant transmission rates in world. A pilot program using polymerase chain reaction (PCR)-based testing dried blood spot (DBS) specimens was implemented to enable early identification HIV-infected infants and timely referral linkage care. From February 2007 October 2008, whole collected by finger prick prepare DBS from <18 months presenting six public mother-and-child health facilities Lagos, Nigeria. The were tested Roche Amplicor...
Determining an accurate estimate of SARS-CoV-2 seroprevalence has been challenging in African countries where malaria and other pathogens are endemic. We compared the performance one single-antigen assay three multi-antigen IgG assays a Nigerian population endemic for malaria. De-identified plasma specimens from RT-PCR positive, dried blood spot (DBS) pre-pandemic negatives were used to evaluate four (Tetracore, SARS2MBA, RightSign, xMAP). Results showed higher sensitivity with (81%...
Abstract Prevalence estimates are critical for malaria programming efforts but generating these from non-malaria surveys is not standard practice. Malaria prevalence 6–59-month-old Nigerian children were compared between two national household performed simultaneously in 2018: a Demographic and Health Survey (DHS) the Nigeria HIV/AIDS Indicator Impact (NAIIS). DHS tested via microscopy (n = 8298) HRP2-based rapid diagnostic test (RDT, n 11,351), NAIIS collected dried blood spots (DBS) which...
Abstract Objective Viral load suppression (VLS) is critical in reducing morbidity and mortality associated with HIV as well minimizing the likelihood of transmission to uninfected persons. The objective this study was identify factors VLS among people living (PLWH) on antiretroviral (ARV) therapy inform programme strategies Nigeria. Methods Adult participants, aged 15–64 years, from 2018 Nigeria HIV/AIDS Indicator Impact Survey (NAIIS), who self‐reported be a PLWH or had detectable ARVs,...
ABSTRACT. The first nationally representative, population-based study of schistosomiasis seroprevalence in Nigeria was conducted using blood samples and risk-factor data collected during the 2018 HIV/AIDS Indicator Impact Survey (NAIIS). Schistosomiasis estimated by analyzing for reactivity to schistosome soluble egg antigen (SEA) a multiplex bead assay; NAIIS survey were assessed identify potential risk factors seropositivity. SEA antibody available 31,459 children aged 0 14 years. Overall...
Objective There is a need for reliable serological assays to determine accurate estimates of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence. Most single target antigen have shown some limitations in Africa. To assess the performance multi-antigen assay, we evaluated commercially available SARS-CoV-2 Multi-Antigen IgG assay human disease 2019 (COVID-19) Nigeria. Methods Validation xMAP was carried out using well-characterized reverse transcription polymerase chain...
Background: The need for accurate HIV annual program planning data motivated the compressed timeline 2018 Nigerian HIV/AIDS Indicator and Impact Survey (NAIIS). survey team used stakeholder cooperation responsive design, using process paradata to refine implementation, quickly collect high-quality data. We describe processes that led generation of funding decisions, ensuring services were funded in 2019. Setting: Nigeria is most populous country Africa, with approximately 195 million people...
A 2014 report evaluating accuracy of serologic testing for transfusion-transmissible viruses at African blood center laboratories found sensitivities 92%, 87%, and 90% detecting infections with human immunodeficiency virus (HIV), hepatitis B (HBV), C (HCV), respectively (1). Following substantial investments in national transfusion service (NBTS) laboratories, 2017 investigators tested proficiency 84 (29 NBTS 55 non-NBTS) seven countries. blinded panel 25 plasma samples was shipped to each...
Objective: Demonstrate if the introduction of more and efficacious antiretroviral (ARV) combinations for prevention mother-to-child transmission (PMTCT) over time translated into a declining HIV-infection among HIV-exposed infants. Methods: This was retrospective review routinely collected PMTCT service data from 2008 to 2014 in 682 secondary tertiary health facilities across Nigeria. The ARV regimen measured by proportions different regimens received HIV-positive pregnant women each year...
Multiplex assays for malaria antigen detection can gather data from large sample sets, but considerations the consistency and quality assurance (QA) of mass testing lack evaluation. We present a QA framework study occurring November 2019 to March 2020 involving 504 assay plates detecting four Plasmodium antigens: pan-Plasmodium aldolase lactate dehydrogenase (LDH), histidine-rich protein 2 (HRP2), P. vivax LDH (PvLDH). Controls on each plate included buffer blank, negative blood, 4-point...