A5071974754- SARS-CoV-2 and COVID-19 Research
- COVID-19 epidemiological studies
- COVID-19 Clinical Research Studies
- Mosquito-borne diseases and control
- SARS-CoV-2 detection and testing
- Diphtheria, Corynebacterium, and Tetanus
- Vaccine Coverage and Hesitancy
- Bacterial Infections and Vaccines
- Respiratory viral infections research
- COVID-19 diagnosis using AI
Institute of Human Virology
2021-2024
Accurate SARS-CoV-2 serological assays are critical for COVID-19 serosurveillance. However, previous studies have indicated possible cross-reactivity of these assays, including in areas where malaria is endemic.
Serological surveys provide an objective biological measure of population immunity, and tetanus serological can also assess vaccination coverage. We undertook a national assessment immunity to diphtheria among Nigerian children aged <15 years using stored specimens collected during the 2018 Nigeria HIV/AIDS Indicator Impact Survey, cross-sectional household-based survey. used validated multiplex bead assay test for toxoid-antibodies. In total, 31,456 were tested. Overall, 70.9% 84.3% had at...
Serosurveillance can provide estimates of population-level exposure to infectious pathogens and has been used extensively during the COVID-19 pandemic. Simultaneous, serological testing for multiple be done using bead-based immunoassays add value disease-specific serosurveys. We conducted a validation four SARS-CoV-2 antigens-full-length spike protein, two receptor binding domain proteins, nucleocapsid protein-on our existing multiplex bead assay (MBA) enteric diseases, malaria, vaccine...
Determining an accurate estimate of SARS-CoV-2 seroprevalence has been challenging in African countries where malaria and other pathogens are endemic. We compared the performance one single-antigen assay three multi-antigen IgG assays a Nigerian population endemic for malaria. De-identified plasma specimens from RT-PCR positive, dried blood spot (DBS) pre-pandemic negatives were used to evaluate four (Tetracore, SARS2MBA, RightSign, xMAP). Results showed higher sensitivity with (81%...
Objective There is a need for reliable serological assays to determine accurate estimates of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence. Most single target antigen have shown some limitations in Africa. To assess the performance multi-antigen assay, we evaluated commercially available SARS-CoV-2 Multi-Antigen IgG assay human disease 2019 (COVID-19) Nigeria. Methods Validation xMAP was carried out using well-characterized reverse transcription polymerase chain...